Protein Information

Cytoscape View

UniProt AC / UniProt ID Q7L0Y3 / TM10C_HUMAN
Protein Name tRNA methyltransferase 10 homolog C precursor
Gene Name Name: TRMT10C
Organism Homo sapiens (Human)

DAG View
PRO Name tRNA methyltransferase 10 homolog C (human)
Definition A tRNA methyltransferase 10 homolog C that is encoded in the genome of human.
Short Label hTRMT10C
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q7L0Y3 (TRMT10C) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
T18 Phosphorylation PhosphoSitePlus
K51 Ubiquitination PhosphoSitePlus
T55 Phosphorylation PhosphoSitePlus
K65 Ubiquitination PhosphoSitePlus
K71 Methylation PhosphoSitePlus
S73 Phosphorylation PhosphoSitePlus
K86 Ubiquitination PhosphoSitePlus
T113 Phosphorylation PhosphoSitePlus
T119 Phosphorylation HPRD   PhosphoSitePlus 20068231
C123 S-Nitrosylation dbSNO 26338901
S125 Phosphorylation HPRD   PhosphoSitePlus 20068231
T127 Phosphorylation HPRD 20068231
Y137 Phosphorylation PhosphoSitePlus
T138 Phosphorylation PhosphoSitePlus
K164 Ubiquitination PhosphoSitePlus
T168 Phosphorylation HPRD   PhosphoSitePlus 20068231, 17924679
T169 Phosphorylation PhosphoSitePlus
T272 Phosphorylation HPRD 20068231
Y307 Phosphorylation PhosphoSitePlus
S311 Phosphorylation PhosphoSitePlus
K315 Methylation PhosphoSitePlus
S316 Phosphorylation HPRD   PhosphoSitePlus 20068231
T321 Phosphorylation HPRD 20068231
T333 Phosphorylation PhosphoSitePlus
K340 Acetylation PhosphoSitePlus
S391 Phosphorylation PhosphoSitePlus

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K51 T51 Biomuta DOID:263 / kidney cancer [ cosmic ]
S73 I73 Biomuta DOID:363 / uterine cancer [ cosmic, tcga ]
T119 A119 Biomuta DOID:3571 / liver cancer [ icgc, tcga ] DOID:0070003 / blastoma [ cosmic ]
T138 M138 Biomuta DOID:363 / uterine cancer [ tcga ]
T138 A138 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
T169 A169 Biomuta DOID:9256 / colorectal cancer [ icgc ]
K340 T340 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]