iPTMnet Report for Q7L014 (DDX46)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q7L014 / DDX46_HUMAN
Protein Name Probable ATP-dependent RNA helicase DDX46
Gene Name Name: DDX46
Synonyms:KIAA0801;
Organism Homo sapiens (Human)

PRO ID PR:Q7L014
DAG View
PRO Name probable ATP-dependent RNA helicase DDX46 (human)
Definition A probable ATP-dependent RNA helicase DDX46 that is encoded in the genome of human.
Short Label hDDX46
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q7L014 (DDX46) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
G2 Myristoylation UniProt 25255805
S28 Phosphorylation PhosphoSitePlus
S40 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17081983
S42 Phosphorylation PhosphoSitePlus
S52 Phosphorylation HPRD 20068231
S54 Phosphorylation HPRD 20068231
S60 Phosphorylation PhosphoSitePlus
S62 Phosphorylation PhosphoSitePlus
S79 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17081983
S85 Phosphorylation PhosphoSitePlus
S87 Phosphorylation PhosphoSitePlus
S95 Phosphorylation PhosphoSitePlus
S105 Phosphorylation PhosphoSitePlus
T124 O-Glycosylation GlyGen 34846842
K155 Ubiquitination PhosphoSitePlus
K186 Sumoylation PhosphoSitePlus
K197 Ubiquitination PhosphoSitePlus
S199 Phosphorylation HPRD   PhosphoSitePlus 18452278
S246 Phosphorylation PhosphoSitePlus
K263 Acetylation PhosphoSitePlus   UniProt 19608861
K271 Acetylation PhosphoSitePlus
K271 Ubiquitination PhosphoSitePlus
S277 Phosphorylation HPRD   PhosphoSitePlus 20068231
K279 Acetylation PhosphoSitePlus
K280 Acetylation PhosphoSitePlus
Y294 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332, 18452278
S295 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17081983, 18452278, 18669648, ...19690332, 20068231
S296 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17081983, 18452278, 18669648, ...19690332, 20068231
T305 Phosphorylation PhosphoSitePlus
K316 Ubiquitination PhosphoSitePlus
K325 Ubiquitination PhosphoSitePlus
Y328 Phosphorylation PhosphoSitePlus
K333 Ubiquitination PhosphoSitePlus
Y336 Phosphorylation PhosphoSitePlus
S346 Phosphorylation PhosphoSitePlus   UniProt 23186163
T361 Phosphorylation HPRD   PhosphoSitePlus 20068231
K388 Ubiquitination PhosphoSitePlus
K417 Ubiquitination PhosphoSitePlus
K422 Ubiquitination PhosphoSitePlus
S439 Phosphorylation PhosphoSitePlus
T452 Phosphorylation PhosphoSitePlus
T454 Phosphorylation PhosphoSitePlus
T462 Phosphorylation PhosphoSitePlus
K493 Ubiquitination PhosphoSitePlus
T524 Phosphorylation PhosphoSitePlus
Y525 Phosphorylation PhosphoSitePlus
R551 Methylation PhosphoSitePlus
R554 Methylation PhosphoSitePlus
S576 Phosphorylation PhosphoSitePlus
K577 Ubiquitination PhosphoSitePlus
S591 Phosphorylation PhosphoSitePlus
K637 Ubiquitination PhosphoSitePlus
T669 Phosphorylation PhosphoSitePlus
S677 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...34725712, 30059200, 34019948, 28510447
C696 S-Nitrosylation dbSNO 26338901
K716 Ubiquitination PhosphoSitePlus
Y718 Phosphorylation HPRD 20068231
Y720 Phosphorylation PhosphoSitePlus
T721 Phosphorylation HPRD   PhosphoSitePlus 20068231
Y730 Phosphorylation PhosphoSitePlus
K736 Ubiquitination PhosphoSitePlus
K757 Ubiquitination PhosphoSitePlus
K765 Ubiquitination PhosphoSitePlus
K768 Acetylation PhosphoSitePlus
K776 Acetylation PhosphoSitePlus   UniProt 19608861
K776 Ubiquitination PhosphoSitePlus
K779 Acetylation PhosphoSitePlus
K779 Sumoylation PhosphoSitePlus
K779 Ubiquitination PhosphoSitePlus
T783 Phosphorylation PhosphoSitePlus
K792 Ubiquitination PhosphoSitePlus
S804 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 21406692, 18491316, ...23186163, 17081983, 15302935, 18452278, 19651622, 18669648, 19690332, 19415658, 20068231
S819 Phosphorylation HPRD 20068231
K848 Acetylation PhosphoSitePlus
K848 Ubiquitination PhosphoSitePlus
K853 Ubiquitination PhosphoSitePlus
R882 Methylation PhosphoSitePlus
T885 Phosphorylation PhosphoSitePlus
S892 Phosphorylation PhosphoSitePlus
K894 Ubiquitination PhosphoSitePlus
T895 Phosphorylation PhosphoSitePlus
K903 Acetylation PhosphoSitePlus
K903 Ubiquitination PhosphoSitePlus
K907 Acetylation PhosphoSitePlus
K907 Ubiquitination PhosphoSitePlus
Y910 Phosphorylation PhosphoSitePlus
K915 Acetylation PhosphoSitePlus
K915 Ubiquitination PhosphoSitePlus
S928 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 20068231
K930 Acetylation PhosphoSitePlus
K930 Ubiquitination PhosphoSitePlus
Y932 Phosphorylation PhosphoSitePlus
T944 Phosphorylation PhosphoSitePlus
K952 Ubiquitination PhosphoSitePlus
T1006 Phosphorylation PhosphoSitePlus
K1010 Ubiquitination PhosphoSitePlus
Y1020 Phosphorylation PhosphoSitePlus
K1025 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S52 C52 Biomuta DOID:1324 / lung cancer [ cosmic ]
S85 C85 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S95 N95 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S105 F105 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K155 T155 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K280 N280 Biomuta DOID:3571 / liver cancer [ cosmic ]
T305 A305 Biomuta DOID:363 / uterine cancer [ icgc ]
K325 T325 Biomuta DOID:363 / uterine cancer [ icgc ]
K333 T333 Biomuta DOID:3571 / liver cancer [ cosmic ]
T524 S524 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ]
Y525 * Biomuta DOID:4159 / skin cancer [ cosmic ]
R551 H551 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R551 C551 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R554 * Biomuta DOID:4159 / skin cancer [ cosmic ]
C696 F696 Biomuta [ cosmic ]
Y730 C730 Biomuta DOID:263 / kidney cancer [ cosmic ]
K792 M792 Biomuta DOID:184 / bone cancer [ cosmic ]
S804 L804 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
K853 N853 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
R882 S882 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K915 N915 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
Y932 C932 Biomuta DOID:3571 / liver cancer [ cosmic ]