iPTMnet Report for Q7KZI7 (MARK2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q7KZI7 / MARK2_HUMAN
Protein Name Serine/threonine-protein kinase MARK2
Gene Name Name: MARK2
Synonyms:EMK1;
Organism Homo sapiens (Human)

PRO ID PR:Q7KZI7
DAG View
PRO Name serine/threonine-protein kinase MARK2 (human)
Definition A serine/threonine-protein kinase MARK2 that is encoded in the genome of human.
Short Label hMARK2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q7KZI7 (MARK2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T6 Phosphorylation PhosphoSitePlus
T20 Phosphorylation PhosphoSitePlus
S26 Phosphorylation PhosphoSitePlus
K27 Ubiquitination PhosphoSitePlus
S29 Phosphorylation PhosphoSitePlus
S30 Phosphorylation PhosphoSitePlus
S40 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17192257, ...18220336
T42 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
S43 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
T58 Phosphorylation PhosphoSitePlus
K61 Ubiquitination PhosphoSitePlus
K77 Ubiquitination PhosphoSitePlus
K82 Ubiquitination PhosphoSitePlus
K86 Ubiquitination PhosphoSitePlus
T87 Phosphorylation PhosphoSitePlus
S91 Phosphorylation Q14012 (CAMK1) neXtProt 17442826
S92 Phosphorylation Q14012 (CAMK1) neXtProt 17442826
S93 Phosphorylation Q14012 (CAMK1) neXtProt 17442826
S161 Phosphorylation PhosphoSitePlus
Y165 Phosphorylation PhosphoSitePlus
K177 Ubiquitination PhosphoSitePlus
S197 Phosphorylation PhosphoSitePlus
T201 Phosphorylation PhosphoSitePlus
T208 Phosphorylation Q15831 (STK11) , Q7L7X3 (TAOK1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 28711359, 19369195, 17573348, ...18424437, 27843979, 14976552, 17192257, 16257959, 14517247
S212 Phosphorylation P49841 (GSK3B) neXtProt   PhosphoSitePlus   RLIMS-P 16257959, 18424437, 27465397
K224 Ubiquitination PhosphoSitePlus
S290 Phosphorylation PhosphoSitePlus
T294 Phosphorylation Q14012 (CAMK1) neXtProt 17442826
K300 Ubiquitination PhosphoSitePlus
Y323 Phosphorylation PhosphoSitePlus
T329 Phosphorylation PhosphoSitePlus
Y337 Phosphorylation PhosphoSitePlus
T338 Phosphorylation PhosphoSitePlus
Y351 Phosphorylation PhosphoSitePlus
Y358 Phosphorylation PhosphoSitePlus
Y363 Phosphorylation PhosphoSitePlus
S365 Phosphorylation PhosphoSitePlus
T372 Phosphorylation PhosphoSitePlus
K376 Phosphorylation UniProt 19369195, 18669648
K376 Ubiquitination PhosphoSitePlus
S380 Phosphorylation PhosphoSitePlus
S386 Phosphorylation PhosphoSitePlus
S390 Phosphorylation PhosphoSitePlus
K394 Ubiquitination PhosphoSitePlus
S398 Phosphorylation PhosphoSitePlus
S400 Phosphorylation Q9BZL6 (PRKD2) , Q7KZI7 (MARK2) , Q15139 (PRKD1) neXtProt   PhosphoSitePlus 19011111
S409 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 18669648, 19369195
S422 Phosphorylation PhosphoSitePlus
S449 Phosphorylation PhosphoSitePlus
S456 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 19369195, 18088087, 16964243, ...18220336, 15302935, 17192257, 18691976, 18669648, 22238634, 23186163
T466 Phosphorylation PhosphoSitePlus
T467 Phosphorylation PhosphoSitePlus   UniProt 23186163
T469 Phosphorylation phospho.ELM   PhosphoSitePlus 17192257
S471 Phosphorylation PhosphoSitePlus
T472 Phosphorylation PhosphoSitePlus
S477 Phosphorylation PhosphoSitePlus
S479 Phosphorylation phospho.ELM   PhosphoSitePlus 17192257
S483 Phosphorylation PhosphoSitePlus
S486 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 19369195, 21406692, 23186163, ...17081983, 18220336, 17192257, 18691976
S493 Phosphorylation PhosphoSitePlus   UniProt 18691976
S498 Phosphorylation PhosphoSitePlus
S505 Phosphorylation PhosphoSitePlus
S514 Phosphorylation PhosphoSitePlus
S533 Phosphorylation PhosphoSitePlus
S535 Phosphorylation PhosphoSitePlus
N541 N-Glycosylation GlyGen 24190977
S569 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 17192257, ...18220336
S571 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17192257, 18220336
N574 N-Glycosylation GlyGen 24190977
S576 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 18220336
S578 Phosphorylation PhosphoSitePlus
R589 Methylation PhosphoSitePlus
S592 Phosphorylation PhosphoSitePlus   UniProt 23186163
S593 Phosphorylation PhosphoSitePlus
S595 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
T596 Phosphorylation Q05513 (PRKCZ) , P41743 (PRKCI) neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 15084291, 23186163, 15324659
Y613 Phosphorylation PhosphoSitePlus
T616 Phosphorylation PhosphoSitePlus
S619 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 18220336, ...17192257, 18669648
S621 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
S624 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
R628 Methylation PhosphoSitePlus
S631 Phosphorylation phospho.ELM   PhosphoSitePlus 17192257
S633 Phosphorylation PhosphoSitePlus
K637 Ubiquitination PhosphoSitePlus
K641 Ubiquitination PhosphoSitePlus
S648 Phosphorylation PhosphoSitePlus
T667 Phosphorylation PhosphoSitePlus
S675 Phosphorylation PhosphoSitePlus
S692 Phosphorylation PhosphoSitePlus
S698 Phosphorylation PhosphoSitePlus
K716 Ubiquitination PhosphoSitePlus
S722 Phosphorylation PhosphoSitePlus   UniProt 19369195
S759 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T6 Phosphorylation HPRD 18691976
S40 Phosphorylation HPRD 18691976, 20068231
T42 Phosphorylation HPRD 18691976
S43 Phosphorylation HPRD 18691976
T208 Phosphorylation HPRD 19664994
S212 Phosphorylation HPRD 19664994
T384 Phosphorylation HPRD 18691976
S390 Phosphorylation HPRD 18691976
S409 Phosphorylation HPRD 18691976
T419 Phosphorylation HPRD 18691976
S456 Phosphorylation HPRD 19413330, 18691976, 18088087, ...20058876, 19664994, 19664995, 17322306, 18669648, 20068231
T466 Phosphorylation HPRD 18691976
S471 Phosphorylation HPRD 18691976
T472 Phosphorylation HPRD 18691976
S479 Phosphorylation HPRD 18691976
S483 Phosphorylation HPRD 19651622, 18691976
S486 Phosphorylation HPRD 18691976, 18212344, 18767875, ...19691289, 19664995, 19651622, 17322306, 20166139
S493 Phosphorylation HPRD 18691976
S569 Phosphorylation HPRD 18691976, 18669648, 20068231
S576 Phosphorylation HPRD 18691976, 18669648
T596 Phosphorylation HPRD 20068231
Y613 Phosphorylation HPRD 18691976
S619 Phosphorylation HPRD 18691976, 18669648, 20068231
S621 Phosphorylation HPRD 18691976, 20068231
S624 Phosphorylation HPRD 18669648
S631 Phosphorylation HPRD 18691976, 20068231
T667 Phosphorylation HPRD 18691976
S769 Phosphorylation HPRD 18691976
Site PTM Type PTM Enzyme Score Source PMID
S460 Phosphorylation PhosphoSitePlus
S465 Phosphorylation PhosphoSitePlus
S482 Phosphorylation PhosphoSitePlus
S484 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T175 Phosphorylation PhosphoSitePlus
T324 Phosphorylation PhosphoSitePlus
S376 Phosphorylation PhosphoSitePlus
T385 Phosphorylation PhosphoSitePlus
S386 Phosphorylation PhosphoSitePlus
S388 Phosphorylation PhosphoSitePlus
Y389 Phosphorylation PhosphoSitePlus
S390 Phosphorylation PhosphoSitePlus
S531 Phosphorylation PhosphoSitePlus
S536 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S7 Phosphorylation HPRD 18691976, 20068231
T9 Phosphorylation HPRD 18691976
S10 Phosphorylation HPRD 18691976
T175 Phosphorylation HPRD   PhosphoSitePlus 19664994
S179 Phosphorylation HPRD 19664994
T351 Phosphorylation HPRD 18691976
S357 Phosphorylation HPRD 18691976
S376 Phosphorylation HPRD   PhosphoSitePlus 19651622, 18669648
T385 Phosphorylation PhosphoSitePlus
S386 Phosphorylation PhosphoSitePlus
S388 Phosphorylation PhosphoSitePlus
Y389 Phosphorylation PhosphoSitePlus
S390 Phosphorylation PhosphoSitePlus
S422 Phosphorylation HPRD 19413330, 18691976, 18088087, ...20058876, 19664994, 19664995, 17322306, 18669648, 20068231
T432 Phosphorylation HPRD 18691976
S437 Phosphorylation HPRD 18691976
T438 Phosphorylation HPRD 18691976
S445 Phosphorylation HPRD 18691976
S449 Phosphorylation HPRD 19651622, 18691976
S452 Phosphorylation HPRD 18691976, 18212344, 18767875, ...19691289, 19664995, 19651622, 17322306, 20166139
S459 Phosphorylation HPRD 18691976
S535 Phosphorylation HPRD 18691976, 18669648, 20068231
S542 Phosphorylation HPRD 18691976, 18669648
T562 Phosphorylation HPRD 15324659, 20068231
Y579 Phosphorylation HPRD 18691976
S585 Phosphorylation HPRD   PhosphoSitePlus 18691976, 18669648, 20068231
S587 Phosphorylation HPRD 18691976, 20068231
S590 Phosphorylation HPRD   PhosphoSitePlus 18669648
S597 Phosphorylation HPRD 18691976, 20068231
T624 Phosphorylation HPRD 18691976
S726 Phosphorylation HPRD 18691976
Site PTM Type PTM Enzyme Score Source PMID
T6 Phosphorylation HPRD 18691976
S40 Phosphorylation HPRD 18691976, 20068231
T42 Phosphorylation HPRD 18691976
S43 Phosphorylation HPRD 18691976
T208 Phosphorylation HPRD 19664994
S212 Phosphorylation HPRD 19664994
T384 Phosphorylation HPRD 18691976
S390 Phosphorylation HPRD 18691976
S409 Phosphorylation HPRD 19651622, 18669648
S455 Phosphorylation HPRD 19413330, 18691976, 18088087, ...20058876, 19664994, 19664995, 17322306, 18669648, 20068231
T465 Phosphorylation HPRD 18691976
S470 Phosphorylation HPRD 18691976
T471 Phosphorylation HPRD 18691976
S478 Phosphorylation HPRD 18691976
S482 Phosphorylation HPRD 19651622, 18691976
S485 Phosphorylation HPRD 18691976, 18212344, 18767875, ...19691289, 19664995, 19651622, 17322306, 20166139
S492 Phosphorylation HPRD 18691976
S514 Phosphorylation HPRD 18691976, 18669648, 20068231
S516 Phosphorylation HPRD 18691976
S521 Phosphorylation HPRD 18691976, 18669648
T541 Phosphorylation HPRD 15324659, 20068231
Y558 Phosphorylation HPRD 18691976
S564 Phosphorylation HPRD 18691976, 18669648, 20068231
S566 Phosphorylation HPRD 18691976, 20068231
S569 Phosphorylation HPRD 18669648
S576 Phosphorylation HPRD 18691976, 20068231
T603 Phosphorylation HPRD 18691976
S705 Phosphorylation HPRD 18691976
Site PTM Type PTM Enzyme Score Source PMID
S40 Phosphorylation phospho.ELM 18220336
T42 Phosphorylation phospho.ELM 18220336
S43 Phosphorylation phospho.ELM 18220336
T208 Phosphorylation PhosphoSitePlus
S456 Phosphorylation phospho.ELM 18220336
S486 Phosphorylation phospho.ELM 18220336
S493 Phosphorylation PhosphoSitePlus
S498 Phosphorylation PhosphoSitePlus
S515 Phosphorylation PhosphoSitePlus
S517 Phosphorylation PhosphoSitePlus
S565 Phosphorylation PhosphoSitePlus
S570 Phosphorylation PhosphoSitePlus


Q7KZI7 (MARK2) as PTM Enzyme



Substrate Site Score Source PMID
P10636-8 (MAPT) S262 neXtProt   PhosphoSitePlus 20067632, 17573348, 23001711, ...21311567, 17360912
P10636-8 (MAPT) S356 PhosphoSitePlus 20067632
P46939 (UTRN) S1258 PhosphoSitePlus   Signor 19945424
P56524 (HDAC4) S246 PhosphoSitePlus 16980613
P78352 (DLG4) S561 neXtProt   PhosphoSitePlus 22807451
Q53ET0 (CRTC2) S171 neXtProt 18626018
Q53ET0 (CRTC2) S274 neXtProt 18626018
Q7KZI7 (MARK2) S400 PhosphoSitePlus 19011111
Q7L804 (RAB11FIP2) S227 neXtProt   PhosphoSitePlus   Signor 16775013, 22553350
Q8TEW0 (PARD3) S144 PhosphoSitePlus 22883624
Q8TEW0 (PARD3) S873 PhosphoSitePlus   Signor 22883624
Q8WUI4 (HDAC7) S155 neXtProt   PhosphoSitePlus   Signor 16980613
Q92974 (ARHGEF2) S143 PhosphoSitePlus 21513698
Q92974 (ARHGEF2) S172 PhosphoSitePlus 21513698
Q92974 (ARHGEF2) S186 PhosphoSitePlus 21513698
Q92974-2 (ARHGEF2) S885 PhosphoSitePlus 22072711
Q92974 (ARHGEF2) S886 neXtProt   Signor 22072711
Q92974-2 (ARHGEF2) S959 PhosphoSitePlus 22072711
Q92974 (ARHGEF2) S960 neXtProt   Signor 22072711
Q9BXM7 (PINK1) T313 neXtProt   PhosphoSitePlus 22238344
Q9H4P4 (RNF41) S254 PhosphoSitePlus 24259665
Q9NQT8 (KIF13B) S1381 neXtProt   PhosphoSitePlus 20194617
Q9NQT8 (KIF13B) S1410 neXtProt   PhosphoSitePlus 20194617
Q9UQB8 (BAIAP2) S366 PhosphoSitePlus 21282462
Q9UQL6 (HDAC5) S259 PhosphoSitePlus 16980613


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K86 N86 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y165 C165 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K177 N177 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S197 N197 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
T201 P201 Biomuta DOID:1612 / breast cancer [ cosmic ]
S290 N290 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K300 Q300 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
Y351 * Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S357 Y357 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y363 * Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
T372 I372 Biomuta DOID:1612 / breast cancer [ cosmic ]
K376 T376 Biomuta DOID:263 / kidney cancer [ cosmic ]
S390 Y390 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S449 N449 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T469 P469 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S477 F477 Biomuta DOID:4159 / skin cancer [ cosmic ]
S514 Y514 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S514 F514 Biomuta DOID:4159 / skin cancer [ cosmic ]
S535 F535 Biomuta DOID:4159 / skin cancer [ cosmic ]
T541 P541 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
N541 Y541 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T562 P562 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S569 F569 Biomuta DOID:4159 / skin cancer [ cosmic ]
T596 P596 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ] DOID:263 / kidney cancer [ cosmic, icgc ]
T603 M603 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ]
T624 M624 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ]
K641 R641 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T667 M667 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ]
S705 L705 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S726 L726 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S759 F759 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
S769 L769 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]