iPTMnet Report for Q76N89 (HECW1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q76N89 / HECW1_HUMAN
Protein Name E3 ubiquitin-protein ligase HECW1
Gene Name Name: HECW1
Synonyms:KIAA0322,NEDL1;
Organism Homo sapiens (Human)

PRO ID PR:Q76N89
DAG View
PRO Name E3 ubiquitin-protein ligase HECW1 (human)
Definition An E3 ubiquitin-protein ligase HECW1 that is encoded in the genome of human.
Short Label hHECW1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q76N89 (HECW1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K9 Ubiquitination PhosphoSitePlus
S24 Phosphorylation PhosphoSitePlus
S26 Phosphorylation PhosphoSitePlus
S68 Phosphorylation PhosphoSitePlus
Y150 Phosphorylation PhosphoSitePlus
K188 Ubiquitination PhosphoSitePlus
S206 Phosphorylation PhosphoSitePlus
S208 Phosphorylation PhosphoSitePlus
S210 Phosphorylation PhosphoSitePlus
Y228 Phosphorylation PhosphoSitePlus
T493 O-Glycosylation GlyGen 29351928
K504 Ubiquitination PhosphoSitePlus
S527 Phosphorylation PhosphoSitePlus
K592 Ubiquitination PhosphoSitePlus
S721 Phosphorylation PhosphoSitePlus
T854 Phosphorylation PhosphoSitePlus
S872 Phosphorylation PhosphoSitePlus
S919 Phosphorylation PhosphoSitePlus
S921 Phosphorylation PhosphoSitePlus
S937 Phosphorylation PhosphoSitePlus
S939 Phosphorylation PhosphoSitePlus
S943 Phosphorylation PhosphoSitePlus
T959 Phosphorylation PhosphoSitePlus
S1075 Phosphorylation PhosphoSitePlus
S1089 Phosphorylation PhosphoSitePlus
S1473 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S24 T24 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S68 C68 Biomuta DOID:1324 / lung cancer [ cosmic ]
S68 T68 Biomuta DOID:1324 / lung cancer [ cosmic ]
S527 T527 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S527 W527 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S721 Y721 Biomuta DOID:4159 / skin cancer [ cosmic ]
S721 F721 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S872 L872 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S939 F939 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S939 Y939 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S943 L943 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1089 F1089 Biomuta DOID:4159 / skin cancer [ cosmic ]