iPTMnet Report for Q76L83 (ASXL2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q76L83 / ASXL2_HUMAN
Protein Name Putative Polycomb group protein ASXL2
Gene Name Name: ASXL2
Synonyms:ASXH2,KIAA1685;
Organism Homo sapiens (Human)

PRO ID PR:Q76L83
DAG View
PRO Name putative Polycomb group protein ASXL2 (human)
Definition A putative Polycomb group protein ASXL2 that is encoded in the genome of human.
Short Label hASXL2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q76L83 (ASXL2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S30 Phosphorylation IEDB 35494241
T62 Phosphorylation PhosphoSitePlus
S64 Phosphorylation PhosphoSitePlus
S95 Phosphorylation PhosphoSitePlus
S98 Phosphorylation PhosphoSitePlus
S136 Phosphorylation PhosphoSitePlus
S137 Phosphorylation PhosphoSitePlus
S138 Phosphorylation PhosphoSitePlus
S139 Phosphorylation PhosphoSitePlus
S142 Phosphorylation PhosphoSitePlus
S146 Phosphorylation PhosphoSitePlus   UniProt 18669648
T148 Phosphorylation PhosphoSitePlus
S156 Phosphorylation IEDB   PhosphoSitePlus 27869121
K163 Acetylation PhosphoSitePlus
K167 Acetylation PhosphoSitePlus
S218 Phosphorylation PhosphoSitePlus
S224 Phosphorylation PhosphoSitePlus
T258 Phosphorylation PhosphoSitePlus
K289 Ubiquitination PhosphoSitePlus
K362 Ubiquitination PhosphoSitePlus
K365 Ubiquitination PhosphoSitePlus
K370 Ubiquitination PhosphoSitePlus
S376 Phosphorylation PhosphoSitePlus
S395 Phosphorylation PhosphoSitePlus
S397 Phosphorylation PhosphoSitePlus
S411 O-Glycosylation GlyGen 34019948, 35254053, 35132862, ...31492838, 35289036, 30620550, 28657654, 29237092, 30059200
S415 O-Glycosylation GlyGen 34019948, 35254053, 35132862, ...31492838, 35289036, 30620550, 28657654, 29237092, 30059200
S440 Phosphorylation PhosphoSitePlus
S517 Phosphorylation PhosphoSitePlus
S524 Phosphorylation PhosphoSitePlus   UniProt 23186163
S530 Phosphorylation PhosphoSitePlus
T557 Phosphorylation PhosphoSitePlus
S562 Phosphorylation PhosphoSitePlus   UniProt 23186163
S565 Phosphorylation PhosphoSitePlus
S570 Phosphorylation PhosphoSitePlus
S571 Phosphorylation PhosphoSitePlus   UniProt 23186163
S580 Phosphorylation PhosphoSitePlus
S600 Phosphorylation PhosphoSitePlus   UniProt 23186163
R607 Methylation PhosphoSitePlus
S627 Phosphorylation PhosphoSitePlus
S637 Phosphorylation PhosphoSitePlus   UniProt 23186163
R639 Methylation PhosphoSitePlus
R641 Methylation PhosphoSitePlus
S648 Phosphorylation PhosphoSitePlus   UniProt 23186163
T652 Phosphorylation PhosphoSitePlus
S714 Phosphorylation PhosphoSitePlus
S834 Phosphorylation PhosphoSitePlus
T836 Phosphorylation PhosphoSitePlus
S842 Phosphorylation PhosphoSitePlus
S845 Phosphorylation PhosphoSitePlus
T854 Phosphorylation PhosphoSitePlus
S905 O-Glycosylation GlyGen 32938750, 34019948, 30620550, ...35132862, 31492838, 35289036, 35254053, 28657654, 29237092, 30059200
T907 O-Glycosylation GlyGen 32938750, 34019948, 30620550, ...35132862, 31492838, 35289036, 35254053, 28657654, 29237092, 30059200
T996 Phosphorylation PhosphoSitePlus
S1002 Phosphorylation PhosphoSitePlus
T1003 Phosphorylation PhosphoSitePlus
Y1054 Phosphorylation PhosphoSitePlus
S1059 Phosphorylation PhosphoSitePlus
T1141 Phosphorylation PhosphoSitePlus
S1143 Phosphorylation PhosphoSitePlus
S1154 Phosphorylation PhosphoSitePlus
T1164 Phosphorylation PhosphoSitePlus
S1173 Phosphorylation PhosphoSitePlus
S1174 Phosphorylation PhosphoSitePlus
S1175 Phosphorylation PhosphoSitePlus
T1181 Phosphorylation PhosphoSitePlus
K1232 Sumoylation PhosphoSitePlus
K1245 Ubiquitination PhosphoSitePlus
T1255 Phosphorylation PhosphoSitePlus
K1259 Sumoylation PhosphoSitePlus
K1259 Ubiquitination PhosphoSitePlus
T1260 Phosphorylation PhosphoSitePlus
K1271 Ubiquitination PhosphoSitePlus
S1284 Phosphorylation PhosphoSitePlus
K1315 Sumoylation PhosphoSitePlus
S1319 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1430 Phosphorylation IEDB   PhosphoSitePlus 32387766
Site PTM Type PTM Enzyme Score Source PMID
S136 Phosphorylation HPRD 18669648
S137 Phosphorylation HPRD 18669648
S138 Phosphorylation HPRD 18669648
S139 Phosphorylation HPRD 19413330, 18669648
S142 Phosphorylation HPRD 19413330
S146 Phosphorylation HPRD 19413330, 18669648
S224 Phosphorylation HPRD 19413330
S395 Phosphorylation HPRD 18669648, 15302935, 20068231
S397 Phosphorylation HPRD 18669648, 20068231
S517 Phosphorylation HPRD 17525332
S524 Phosphorylation HPRD 18452278
S562 Phosphorylation HPRD 19413330, 19664994
S571 Phosphorylation HPRD 18452278
S600 Phosphorylation HPRD 20068231
S834 Phosphorylation HPRD 20068231
S842 Phosphorylation HPRD 20068231
S845 Phosphorylation HPRD 20068231
S1319 Phosphorylation HPRD 15302935, 20068231
S1430 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S64 A64 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S64 F64 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S64 Y64 Biomuta DOID:4159 / skin cancer [ cosmic ]
S95 * Biomuta DOID:1612 / breast cancer [ cosmic ]
S136 L136 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
S138 Y138 Biomuta DOID:1324 / lung cancer [ cosmic ]
S138 F138 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S139 F139 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S146 L146 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S156 C156 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S156 F156 Biomuta [ cosmic ] DOID:363 / uterine cancer [ icgc ]
K163 N163 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K289 R289 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S395 F395 Biomuta DOID:4159 / skin cancer [ cosmic ]
S411 F411 Biomuta [ cosmic ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic ]
S517 G517 Biomuta DOID:263 / kidney cancer [ cosmic ]
S570 C570 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S571 F571 Biomuta DOID:4159 / skin cancer [ cosmic ]
R641 C641 Biomuta DOID:3571 / liver cancer [ cosmic ]
S714 I714 Biomuta DOID:1324 / lung cancer [ cosmic ]
T836 I836 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S842 L842 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S845 * Biomuta DOID:1324 / lung cancer [ cosmic ]
T1003 A1003 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S1059 R1059 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1143 F1143 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1143 Y1143 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1154 T1154 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1173 R1173 Biomuta DOID:2174 / ocular cancer [ cosmic ]
S1174 N1174 Biomuta DOID:3571 / liver cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
S1175 I1175 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
K1245 T1245 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
T1260 I1260 Biomuta DOID:4159 / skin cancer [ cosmic ]
K1315 R1315 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]