iPTMnet Report for Q75QN2 (INTS8)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q75QN2 / INT8_HUMAN
Protein Name Integrator complex subunit 8
Gene Name Name: INTS8
Synonyms:C8orf52;
Organism Homo sapiens (Human)

PRO ID PR:Q75QN2
DAG View
PRO Name integrator complex subunit 8 (human)
Definition An integrator complex subunit 8 that is encoded in the genome of human.
Short Label hINTS8
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q75QN2 (INTS8) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T18 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17081983
T22 Phosphorylation PhosphoSitePlus
S62 Phosphorylation PhosphoSitePlus
K165 Ubiquitination PhosphoSitePlus
K189 Ubiquitination PhosphoSitePlus
K210 Ubiquitination PhosphoSitePlus
K242 Ubiquitination PhosphoSitePlus
C253 Methylation IEDB 31844290
C295 Methylation IEDB 31844290
K369 Ubiquitination PhosphoSitePlus
C381 Methylation IEDB 31844290
K430 Ubiquitination PhosphoSitePlus
K436 Acetylation PhosphoSitePlus
K436 Ubiquitination PhosphoSitePlus
K444 Acetylation PhosphoSitePlus
K475 Ubiquitination PhosphoSitePlus
K584 Ubiquitination PhosphoSitePlus
T601 Phosphorylation PhosphoSitePlus
S604 Phosphorylation PhosphoSitePlus
S636 Phosphorylation PhosphoSitePlus
K702 Ubiquitination PhosphoSitePlus
S710 Phosphorylation PhosphoSitePlus
K743 Ubiquitination PhosphoSitePlus
C863 Methylation IEDB 31844290
K882 Ubiquitination PhosphoSitePlus
K910 Ubiquitination PhosphoSitePlus
K959 Ubiquitination PhosphoSitePlus
K985 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T18 Phosphorylation HPRD 17081983, 18452278
T22 Phosphorylation HPRD 18452278
S62 Phosphorylation HPRD 20068231
S710 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T18 P18 Biomuta DOID:4159 / skin cancer [ cosmic ]
T22 N22 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K210 N210 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]