iPTMnet Report for Q70SY1 (CREB3L2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q70SY1 / CR3L2_HUMAN
Protein Name Cyclic AMP-responsive element-binding protein 3-like protein 2
Gene Name Name: CREB3L2
Synonyms:BBF2H7;
Organism Homo sapiens (Human)

PRO ID PR:Q70SY1
DAG View
PRO Name cyclic AMP-responsive element-binding protein 3-like protein 2 (human)
Definition A cyclic AMP-responsive element-binding protein 3-like protein 2 that is encoded in the genome of human.
Short Label hCREB3L2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q70SY1 (CREB3L2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S72 Phosphorylation PhosphoSitePlus
S93 Phosphorylation PhosphoSitePlus   UniProt 23186163
T131 Methylation IEDB 32357974
C170 Methylation IEDB 31844290
K176 Ubiquitination PhosphoSitePlus
K178 Sumoylation PhosphoSitePlus
K178 Ubiquitination PhosphoSitePlus
S191 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 17081983
S228 Phosphorylation PhosphoSitePlus
T232 Phosphorylation PhosphoSitePlus
S234 Phosphorylation PhosphoSitePlus
S244 Phosphorylation PhosphoSitePlus
S249 Phosphorylation PhosphoSitePlus
K257 Ubiquitination PhosphoSitePlus
S261 Phosphorylation PhosphoSitePlus
T267 Phosphorylation PhosphoSitePlus
K271 Ubiquitination PhosphoSitePlus
K289 Ubiquitination PhosphoSitePlus
S290 Phosphorylation PhosphoSitePlus
K305 Sumoylation PhosphoSitePlus
K305 Ubiquitination PhosphoSitePlus
K325 Sumoylation PhosphoSitePlus
K325 Ubiquitination PhosphoSitePlus
K339 Ubiquitination PhosphoSitePlus
K356 Ubiquitination PhosphoSitePlus
K364 Ubiquitination PhosphoSitePlus
T368 Phosphorylation PhosphoSitePlus
N480 N-Glycosylation GlyGen 24190977
T482 Phosphorylation PhosphoSitePlus
N504 N-Glycosylation GlyGen 24190977
Site PTM Type PTM Enzyme Score Source PMID
S191 Phosphorylation HPRD 18669648, 17081983, 20068231
T232 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
C170 W170 Biomuta DOID:3571 / liver cancer [ cosmic ]
C170 F170 Biomuta DOID:1324 / lung cancer [ cosmic ]
K176 E176 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S249 F249 Biomuta DOID:4159 / skin cancer [ cosmic ]
T267 I267 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
K305 N305 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]