iPTMnet Report for Q70EL4 (USP43)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q70EL4 / UBP43_HUMAN
Protein Name Ubiquitin carboxyl-terminal hydrolase 43
Gene Name Name: USP43
Organism Homo sapiens (Human)

PRO ID PR:Q70EL4
DAG View
PRO Name ubiquitin carboxyl-terminal hydrolase 43 (human)
Definition A ubiquitin carboxyl-terminal hydrolase 43 that is encoded in the genome of human.
Short Label hUSP43
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q70EL4 (USP43) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T283 Phosphorylation PhosphoSitePlus
S304 Phosphorylation PhosphoSitePlus
T305 Phosphorylation PhosphoSitePlus
S391 Phosphorylation PhosphoSitePlus
S413 Phosphorylation PhosphoSitePlus
S507 Phosphorylation PhosphoSitePlus
S508 Phosphorylation PhosphoSitePlus
S611 Phosphorylation PhosphoSitePlus
S731 Phosphorylation PhosphoSitePlus
S766 Phosphorylation PhosphoSitePlus
T812 Phosphorylation PhosphoSitePlus
S818 Phosphorylation PhosphoSitePlus
Y835 Phosphorylation PhosphoSitePlus
S844 Phosphorylation PhosphoSitePlus
S846 Phosphorylation PhosphoSitePlus
S848 Phosphorylation PhosphoSitePlus
S876 Phosphorylation PhosphoSitePlus
S969 Phosphorylation PhosphoSitePlus
T985 Phosphorylation PhosphoSitePlus
T997 Phosphorylation PhosphoSitePlus
S1041 Phosphorylation PhosphoSitePlus   UniProt 18669648
R1053 Methylation PhosphoSitePlus
S1065 Phosphorylation PhosphoSitePlus
R1071 Methylation PhosphoSitePlus
R1081 Methylation PhosphoSitePlus
S1088 Phosphorylation PhosphoSitePlus
S1098 Phosphorylation PhosphoSitePlus
Y1099 Phosphorylation PhosphoSitePlus
Y1107 Phosphorylation PhosphoSitePlus
T1109 Phosphorylation PhosphoSitePlus
S1111 O-Glycosylation GlyGen 30379171
S1111 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y835 Phosphorylation HPRD 17389395
S846 Phosphorylation HPRD 18669648
S848 Phosphorylation HPRD 18669648
S851 Phosphorylation HPRD 18669648
S1041 Phosphorylation HPRD 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T283 A283 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S304 I304 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S391 P391 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S391 F391 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S413 N413 Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
S507 R507 Biomuta DOID:263 / kidney cancer [ cosmic ]
T812 I812 Biomuta DOID:4159 / skin cancer [ cosmic ]
S818 F818 Biomuta DOID:4159 / skin cancer [ cosmic ]
S851 L851 Biomuta [ cosmic ] DOID:4159 / skin cancer [ cosmic, icgc ]
T997 I997 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
R1071 H1071 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1111 F1111 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]