iPTMnet Report for Q70EK8 (USP53)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q70EK8 / UBP53_HUMAN
Protein Name Inactive ubiquitin carboxyl-terminal hydrolase 53
Gene Name Name: USP53
Synonyms:KIAA1350;
Organism Homo sapiens (Human)

PRO ID PR:Q70EK8
DAG View
PRO Name inactive ubiquitin carboxyl-terminal hydrolase 53 (human)
Definition An inactive ubiquitin carboxyl-terminal hydrolase 53 that is encoded in the genome of human.
Short Label hUSP53
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q70EK8 (USP53) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S22 Phosphorylation PhosphoSitePlus
S95 Phosphorylation PhosphoSitePlus
K231 Ubiquitination PhosphoSitePlus
R328 Methylation PhosphoSitePlus
S369 Phosphorylation PhosphoSitePlus
S510 Phosphorylation PhosphoSitePlus
S572 Phosphorylation PhosphoSitePlus
S798 Phosphorylation PhosphoSitePlus
T839 Phosphorylation PhosphoSitePlus
S848 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S95 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
R328 S328 Biomuta DOID:3571 / liver cancer [ cosmic ]
T839 I839 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T839 K839 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S848 C848 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S848 P848 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]