iPTMnet Report for Q70E73 (RAPH1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q70E73 / RAPH1_HUMAN
Protein Name Ras-associated and pleckstrin homology domains-containing protein 1
Gene Name Name: RAPH1
Synonyms:ALS2CR18,ALS2CR9,KIAA1681,LPD,PREL2,RMO1;
Organism Homo sapiens (Human)

PRO ID PR:Q70E73
DAG View
PRO Name Ras-associated and pleckstrin homology domains-containing protein 1 (human)
Definition A Ras-associated and pleckstrin homology domains-containing protein 1 that is encoded in the genome of human.
Short Label hRAPH1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q70E73 (RAPH1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330, 21406692, 20068231
S5 Phosphorylation PhosphoSitePlus   UniProt 21406692, 20068231
S17 Phosphorylation PhosphoSitePlus   UniProt 21406692, 20068231, 24275569
S41 Phosphorylation PhosphoSitePlus
S54 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
K116 Ubiquitination PhosphoSitePlus
T118 Phosphorylation PhosphoSitePlus
K120 Ubiquitination PhosphoSitePlus
T127 Phosphorylation PhosphoSitePlus
K129 Methylation PhosphoSitePlus
T132 Phosphorylation PhosphoSitePlus
K134 Methylation PhosphoSitePlus
K134 Ubiquitination PhosphoSitePlus
S140 Phosphorylation PhosphoSitePlus
S147 Phosphorylation PhosphoSitePlus
S150 Phosphorylation PhosphoSitePlus   UniProt 24275569
S152 Phosphorylation PhosphoSitePlus
S192 Phosphorylation PhosphoSitePlus   UniProt 24275569
S203 Phosphorylation PhosphoSitePlus   UniProt 24275569
S205 Phosphorylation PhosphoSitePlus   UniProt 24275569
S207 Phosphorylation PhosphoSitePlus
S208 Phosphorylation PhosphoSitePlus
S211 Phosphorylation PhosphoSitePlus
K250 Acetylation PhosphoSitePlus
K250 Ubiquitination PhosphoSitePlus
K270 Acetylation PhosphoSitePlus
S281 Phosphorylation PhosphoSitePlus
S282 Phosphorylation PhosphoSitePlus
Y366 Phosphorylation PhosphoSitePlus
S423 Phosphorylation PhosphoSitePlus
Y426 Phosphorylation neXtProt   PhosphoSitePlus   UniProt 20417104
Y426 Phosphorylation P00519 (ABL1) neXtProt 20417104
Y456 Phosphorylation neXtProt   PhosphoSitePlus   UniProt 20417104
Y456 Phosphorylation P00519 (ABL1) neXtProt 20417104
Y466 Phosphorylation PhosphoSitePlus
Y481 Phosphorylation PhosphoSitePlus
K483 Ubiquitination PhosphoSitePlus
Y510 Phosphorylation PhosphoSitePlus
Y513 Phosphorylation neXtProt   PhosphoSitePlus 20417104
Y513 Phosphorylation P00519 (ABL1) neXtProt 20417104
Y524 Phosphorylation PhosphoSitePlus
S533 Phosphorylation PhosphoSitePlus
S542 Phosphorylation PhosphoSitePlus
S569 Phosphorylation PhosphoSitePlus
S571 Phosphorylation PhosphoSitePlus
S574 Phosphorylation PhosphoSitePlus
S575 Phosphorylation PhosphoSitePlus
S578 Phosphorylation PhosphoSitePlus
K582 Acetylation PhosphoSitePlus
K592 Ubiquitination PhosphoSitePlus
S597 Phosphorylation PhosphoSitePlus
Y602 Phosphorylation PhosphoSitePlus
T603 Phosphorylation PhosphoSitePlus
S604 Phosphorylation PhosphoSitePlus
S610 Phosphorylation neXtProt   PhosphoSitePlus   UniProt 18669648, 22028470
S610 Phosphorylation P28482 (MAPK1) neXtProt 22028470
Y667 Phosphorylation PhosphoSitePlus
T762 Phosphorylation PhosphoSitePlus
T784 O-Glycosylation GlyGen   PhosphoSitePlus 31492838, 35254053, 34019948, ...35289036, 28657654, 20068230
S790 O-Glycosylation GlyGen 31492838, 35254053, 34019948, ...35289036, 28657654, 20068230
T793 O-Glycosylation GlyGen 31492838, 35254053, 34019948, ...35289036, 28657654, 20068230
T799 O-Glycosylation GlyGen 31492838, 35254053, 34019948, ...35289036, 28657654, 20068230
T805 Phosphorylation PhosphoSitePlus
S822 Phosphorylation PhosphoSitePlus
Y823 Phosphorylation PhosphoSitePlus
S827 Phosphorylation PhosphoSitePlus   UniProt 18669648, 20068231
T830 Phosphorylation PhosphoSitePlus   UniProt 18669648, 20068231
T839 Phosphorylation PhosphoSitePlus
S845 Phosphorylation PhosphoSitePlus   UniProt 24275569
S853 Phosphorylation PhosphoSitePlus   UniProt 18669648
S856 Phosphorylation PhosphoSitePlus
S860 Phosphorylation PhosphoSitePlus
S867 Phosphorylation PhosphoSitePlus
T874 Phosphorylation PhosphoSitePlus
S880 Phosphorylation PhosphoSitePlus
S894 Phosphorylation PhosphoSitePlus   UniProt 18669648, 20068231, 24275569
S933 Phosphorylation PhosphoSitePlus
T945 Phosphorylation PhosphoSitePlus
T949 Phosphorylation PhosphoSitePlus
S965 Phosphorylation PhosphoSitePlus   UniProt 18669648
T974 Phosphorylation PhosphoSitePlus   UniProt 18669648
S980 Phosphorylation PhosphoSitePlus
S996 Phosphorylation PhosphoSitePlus   UniProt 24275569
T1005 Phosphorylation PhosphoSitePlus
S1010 Phosphorylation PhosphoSitePlus
S1012 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1014 Phosphorylation PhosphoSitePlus
T1017 Phosphorylation PhosphoSitePlus
S1033 Phosphorylation PhosphoSitePlus
S1047 Phosphorylation PhosphoSitePlus
S1054 Phosphorylation PhosphoSitePlus
S1060 Phosphorylation PhosphoSitePlus
S1066 Phosphorylation PhosphoSitePlus
S1069 Phosphorylation PhosphoSitePlus
S1071 Phosphorylation PhosphoSitePlus
T1123 Phosphorylation PhosphoSitePlus
S1130 Phosphorylation PhosphoSitePlus
T1131 Phosphorylation PhosphoSitePlus
T1134 Phosphorylation PhosphoSitePlus
T1143 Phosphorylation PhosphoSitePlus
T1153 Phosphorylation PhosphoSitePlus
S1154 Phosphorylation IEDB   PhosphoSitePlus 32157095
T1172 Phosphorylation PhosphoSitePlus
S1183 Phosphorylation PhosphoSitePlus   UniProt 24275569
S1185 Phosphorylation PhosphoSitePlus
S1224 Phosphorylation PhosphoSitePlus
Y1226 Phosphorylation neXtProt   PhosphoSitePlus   UniProt 20417104
Y1226 Phosphorylation P00519 (ABL1) neXtProt 20417104
T1228 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S5 Phosphorylation HPRD 19413330, 19651622, 20068231
S17 Phosphorylation HPRD 19413330, 19651622, 20068231
S54 Phosphorylation HPRD 18669648, 20068231
Y524 Phosphorylation HPRD 19901323
S571 Phosphorylation HPRD 18669648
S610 Phosphorylation HPRD 18669648, 20068231
S827 Phosphorylation HPRD 18669648, 20068231
T830 Phosphorylation HPRD 18669648, 20068231
S853 Phosphorylation HPRD 18669648, 20068231
S856 Phosphorylation HPRD 19413330, 18077418, 18669648, ...20068231
S860 Phosphorylation HPRD 18669648
S867 Phosphorylation HPRD 20068231
T874 Phosphorylation HPRD 18077418
S880 Phosphorylation HPRD 18077418
S894 Phosphorylation HPRD 19413330, 18669648, 20068231
S933 Phosphorylation HPRD 20068231
T945 Phosphorylation HPRD 20068231
S965 Phosphorylation HPRD 19413330, 18669648
T974 Phosphorylation HPRD 18669648
S979 Phosphorylation HPRD 18669648
S996 Phosphorylation HPRD 20068231
S1010 Phosphorylation HPRD 20068231
S1012 Phosphorylation HPRD 20068231
S1033 Phosphorylation HPRD 20068231
S1066 Phosphorylation HPRD 20068231
S1069 Phosphorylation HPRD 20068231
S1071 Phosphorylation HPRD 20068231
T1153 Phosphorylation HPRD 18669648, 20068231
S1154 Phosphorylation HPRD 19413330, 15302935, 20068231, ...18452278
Site PTM Type PTM Enzyme Score Source PMID
S248 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S5 Phosphorylation HPRD 19413330, 19651622, 20068231
S17 Phosphorylation HPRD 19413330, 19651622, 20068231
S54 Phosphorylation HPRD 18669648, 20068231
Y576 Phosphorylation HPRD 19901323
S623 Phosphorylation HPRD 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S17 N17 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S17 C17 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S17 R17 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S54 F54 Biomuta DOID:4159 / skin cancer [ cosmic ]
T127 A127 Biomuta DOID:1324 / lung cancer [ cosmic ]
S140 F140 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S140 Y140 Biomuta DOID:4159 / skin cancer [ cosmic ]
S147 F147 Biomuta DOID:1324 / lung cancer [ cosmic ]
K250 T250 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y426 F426 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K483 E483 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S571 I571 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S604 L604 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S623 I623 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T805 P805 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S853 P853 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S860 P860 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S867 I867 Biomuta DOID:363 / uterine cancer [ icgc ]
S965 N965 Biomuta DOID:1319 / brain cancer [ cosmic ]
S996 L996 Biomuta DOID:4159 / skin cancer [ cosmic, icgc, cosmic ] DOID:4606 / bile duct cancer [ cosmic ] DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S1071 Y1071 Biomuta DOID:363 / uterine cancer [ icgc ]
T1123 P1123 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
T1134 N1134 Biomuta DOID:3571 / liver cancer [ cosmic ]
T1228 A1228 Biomuta DOID:1612 / breast cancer [ cosmic ]
T1228 M1228 Biomuta DOID:263 / kidney cancer [ cosmic ]