Protein Information

Cytoscape View


UniProt AC / UniProt ID Q70CQ2 / UBP34_HUMAN
Protein Name Ubiquitin carboxyl-terminal hydrolase 34
Gene Name Name: USP34
Synonyms:KIAA0570,KIAA0729;
Organism Homo sapiens (Human)

PRO ID PR:Q70CQ2
DAG View
PRO Name ubiquitin carboxyl-terminal hydrolase 34 (human)
Definition A ubiquitin carboxyl-terminal hydrolase 34 that is encoded in the genome of human.
Short Label hUSP34
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q70CQ2 (USP34) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S98 Phosphorylation PhosphoSitePlus
K141 Ubiquitination PhosphoSitePlus
K154 Ubiquitination PhosphoSitePlus
S187 Phosphorylation PhosphoSitePlus
T188 Phosphorylation PhosphoSitePlus
S298 Phosphorylation PhosphoSitePlus
K301 Ubiquitination PhosphoSitePlus
K312 Acetylation PhosphoSitePlus
Y321 Phosphorylation PhosphoSitePlus
S324 Phosphorylation PhosphoSitePlus
T326 Phosphorylation PhosphoSitePlus
T328 Phosphorylation PhosphoSitePlus
S352 Phosphorylation PhosphoSitePlus   UniProt 18669648
S355 Phosphorylation PhosphoSitePlus
S465 Phosphorylation PhosphoSitePlus
S483 Phosphorylation PhosphoSitePlus
K484 Ubiquitination PhosphoSitePlus
S486 Phosphorylation PhosphoSitePlus
S487 Phosphorylation PhosphoSitePlus   UniProt 23186163
S490 Phosphorylation PhosphoSitePlus
S590 Phosphorylation PhosphoSitePlus
S649 Phosphorylation PhosphoSitePlus   UniProt 17525332
S658 Phosphorylation PhosphoSitePlus
T679 Phosphorylation PhosphoSitePlus
S681 Phosphorylation PhosphoSitePlus
S718 Phosphorylation Q13315 (ATM) PhosphoSitePlus 17478428
Y827 Phosphorylation PhosphoSitePlus
S832 Phosphorylation PhosphoSitePlus
S844 Phosphorylation PhosphoSitePlus
K857 Ubiquitination PhosphoSitePlus
S920 Phosphorylation PhosphoSitePlus
K1039 Ubiquitination PhosphoSitePlus
K1134 Ubiquitination PhosphoSitePlus
T1194 Phosphorylation PhosphoSitePlus
S1197 Phosphorylation PhosphoSitePlus
S1198 Phosphorylation PhosphoSitePlus
S1204 Phosphorylation PhosphoSitePlus
K1206 Ubiquitination PhosphoSitePlus
S1208 Phosphorylation PhosphoSitePlus
K1250 Ubiquitination PhosphoSitePlus
S1283 Phosphorylation PhosphoSitePlus
S1284 Phosphorylation PhosphoSitePlus
S1458 Phosphorylation PhosphoSitePlus
T1459 Phosphorylation PhosphoSitePlus
S1461 Phosphorylation PhosphoSitePlus
Y1462 Phosphorylation PhosphoSitePlus
S1469 Phosphorylation PhosphoSitePlus
S1472 Phosphorylation PhosphoSitePlus
S1473 Phosphorylation PhosphoSitePlus
S1480 Phosphorylation PhosphoSitePlus
S1503 Phosphorylation PhosphoSitePlus
K1564 Ubiquitination PhosphoSitePlus
K1567 Ubiquitination PhosphoSitePlus
K1574 Ubiquitination PhosphoSitePlus
S1650 Phosphorylation PhosphoSitePlus
K1658 Ubiquitination PhosphoSitePlus
K1714 Ubiquitination PhosphoSitePlus
K1728 Ubiquitination PhosphoSitePlus
K1748 Ubiquitination PhosphoSitePlus
S1751 Phosphorylation Q13315 (ATM) PhosphoSitePlus 17478428
S1826 Phosphorylation PhosphoSitePlus
S1950 Phosphorylation PhosphoSitePlus
K1968 Ubiquitination PhosphoSitePlus
K1977 Ubiquitination PhosphoSitePlus
T2010 Phosphorylation PhosphoSitePlus
S2015 Phosphorylation PhosphoSitePlus
Y2042 Phosphorylation PhosphoSitePlus
Y2060 Phosphorylation PhosphoSitePlus
S2085 Phosphorylation PhosphoSitePlus
Y2091 Phosphorylation PhosphoSitePlus
T2092 Phosphorylation PhosphoSitePlus
T2097 Phosphorylation PhosphoSitePlus
K2100 Ubiquitination PhosphoSitePlus
K2102 Ubiquitination PhosphoSitePlus
T2116 Phosphorylation PhosphoSitePlus
K2126 Ubiquitination PhosphoSitePlus
K2219 Ubiquitination PhosphoSitePlus
S2255 Phosphorylation PhosphoSitePlus
K2334 Ubiquitination PhosphoSitePlus
K2363 Ubiquitination PhosphoSitePlus
S2488 Phosphorylation PhosphoSitePlus   UniProt 19690332
K2508 Ubiquitination PhosphoSitePlus
Y2677 Phosphorylation PhosphoSitePlus
S2690 Phosphorylation PhosphoSitePlus
S2694 Phosphorylation PhosphoSitePlus
S2703 Phosphorylation PhosphoSitePlus
T2704 Phosphorylation PhosphoSitePlus
T2711 Phosphorylation PhosphoSitePlus
T2721 Phosphorylation PhosphoSitePlus
S2865 Phosphorylation PhosphoSitePlus
S3007 Phosphorylation PhosphoSitePlus
Y3011 Phosphorylation PhosphoSitePlus
K3100 Ubiquitination PhosphoSitePlus
K3105 Ubiquitination PhosphoSitePlus
K3205 Ubiquitination PhosphoSitePlus
K3322 Ubiquitination PhosphoSitePlus
K3339 Acetylation PhosphoSitePlus
T3350 Phosphorylation PhosphoSitePlus
S3358 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163
S3359 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163
T3364 Phosphorylation PhosphoSitePlus
T3376 Phosphorylation PhosphoSitePlus
T3381 Phosphorylation PhosphoSitePlus   UniProt 23186163
S3384 Phosphorylation PhosphoSitePlus
T3385 Phosphorylation PhosphoSitePlus
S3386 Phosphorylation PhosphoSitePlus   UniProt 23186163
S3393 Phosphorylation PhosphoSitePlus
S3394 Phosphorylation PhosphoSitePlus
T3400 Phosphorylation PhosphoSitePlus
S3406 Phosphorylation PhosphoSitePlus   UniProt 18669648
S3410 Phosphorylation PhosphoSitePlus
S3411 Phosphorylation PhosphoSitePlus
S3501 Phosphorylation PhosphoSitePlus
S3503 Phosphorylation PhosphoSitePlus   UniProt 24275569
S3507 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T188 Phosphorylation HPRD 18077418
S352 Phosphorylation HPRD 18669648
S355 Phosphorylation HPRD 18669648
T667 Phosphorylation HPRD 20068231
T679 Phosphorylation HPRD 20068231
S681 Phosphorylation HPRD 20068231
S1377 Phosphorylation HPRD 20068231
S1461 Phosphorylation HPRD 18669648
S1469 Phosphorylation HPRD 18669648
S1472 Phosphorylation HPRD 18669648
S1473 Phosphorylation HPRD 18669648
S2488 Phosphorylation HPRD 15345747
S3358 Phosphorylation HPRD 18669648
S3359 Phosphorylation HPRD 18669648
T3383 Phosphorylation HPRD 19651622
S3384 Phosphorylation HPRD 19651622
T3385 Phosphorylation HPRD 19651622
S3406 Phosphorylation HPRD 18669648, 18452278
S3410 Phosphorylation HPRD 18669648
S3411 Phosphorylation HPRD 18669648
Y3415 Phosphorylation HPRD 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K141 N141 Biomuta DOID:4362 / cervical cancer [ tcga ]
S187 * Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S187 L187 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
T188 I188 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
K312 R312 Biomuta DOID:1324 / lung cancer [ cosmic ]
S324 P324 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
T326 S326 Biomuta DOID:1324 / lung cancer [ cosmic ]
S483 Y483 Biomuta DOID:363 / uterine cancer [ tcga ]
S483 C483 Biomuta DOID:0060119 / pharynx cancer [ cosmic ]
S487 Y487 Biomuta DOID:363 / uterine cancer [ tcga ]
S844 I844 Biomuta DOID:363 / uterine cancer [ tcga ]
S1198 N1198 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S1283 A1283 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S1283 L1283 Biomuta DOID:0060119 / pharynx cancer [ cosmic ]
T1459 M1459 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S1469 * Biomuta DOID:3571 / liver cancer [ icgc ]
S1469 L1469 Biomuta DOID:263 / kidney cancer [ cosmic, icgc, tcga ]
S1503 C1503 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
K1564 R1564 Biomuta DOID:263 / kidney cancer [ tcga ]
K1658 N1658 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S1751 G1751 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1826 C1826 Biomuta DOID:3953 / adrenal gland cancer [ tcga ]
T2097 M2097 Biomuta DOID:363 / uterine cancer [ tcga ]
S2255 L2255 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
S2865 Y2865 Biomuta DOID:3571 / liver cancer [ icgc ]
K3100 R3100 Biomuta DOID:11934 / head and neck cancer [ tcga ]
T3350 S3350 Biomuta DOID:11934 / head and neck cancer [ tcga ]
S3358 R3358 Biomuta DOID:3571 / liver cancer [ icgc ]
T3364 A3364 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
T3364 S3364 Biomuta DOID:1612 / breast cancer [ cosmic ]
T3381 A3381 Biomuta DOID:363 / uterine cancer [ cosmic, tcga ]
S3411 Y3411 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]