iPTMnet Report for Q6ZWJ1 (STXBP4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q6ZWJ1 / STXB4_HUMAN
Protein Name Syntaxin-binding protein 4
Gene Name Name: STXBP4
Organism Homo sapiens (Human)

PRO ID PR:Q6ZWJ1
DAG View
PRO Name syntaxin-binding protein 4 (human)
Definition A syntaxin-binding protein 4 that is encoded in the genome of human.
Short Label hSTXBP4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q6ZWJ1 (STXBP4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T5 Phosphorylation PhosphoSitePlus
S6 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S10 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S12 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
K16 Ubiquitination PhosphoSitePlus
K27 Ubiquitination PhosphoSitePlus
K60 Ubiquitination PhosphoSitePlus
K65 Ubiquitination PhosphoSitePlus
S82 Phosphorylation PhosphoSitePlus
S99 Phosphorylation P31751 (AKT2) neXtProt   PhosphoSitePlus   RLIMS-P 17336927, 15753124, 24705589, ...15913552
T151 Phosphorylation PhosphoSitePlus
K156 Ubiquitination PhosphoSitePlus
T157 Phosphorylation PhosphoSitePlus
S163 Phosphorylation PhosphoSitePlus
S164 Phosphorylation PhosphoSitePlus
K168 Ubiquitination PhosphoSitePlus
S208 Phosphorylation PhosphoSitePlus
S212 Phosphorylation PhosphoSitePlus   UniProt 23186163
K233 Ubiquitination PhosphoSitePlus
K248 Ubiquitination PhosphoSitePlus
S252 Phosphorylation PhosphoSitePlus
C265 Methylation IEDB 31844290
K323 Ubiquitination PhosphoSitePlus
K326 Ubiquitination PhosphoSitePlus
K380 Ubiquitination PhosphoSitePlus
K385 Ubiquitination PhosphoSitePlus
Y391 Phosphorylation PhosphoSitePlus
K396 Ubiquitination PhosphoSitePlus
K421 Ubiquitination PhosphoSitePlus
S445 Phosphorylation PhosphoSitePlus
T446 Phosphorylation PhosphoSitePlus
S460 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
S463 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332, 23186163
T465 Phosphorylation PhosphoSitePlus
K483 Ubiquitination PhosphoSitePlus
K487 Ubiquitination PhosphoSitePlus
S545 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T5 Phosphorylation HPRD 18691976
S6 Phosphorylation HPRD 19413330, 18691976, 18669648, ...20068231
S10 Phosphorylation HPRD 19413330, 18691976, 18669648, ...20068231
S12 Phosphorylation HPRD 18669648
S460 Phosphorylation HPRD 17525332
S463 Phosphorylation HPRD 17525332
T465 Phosphorylation HPRD 18691976
Site PTM Type PTM Enzyme Score Source PMID
K240 Ubiquitination PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q6ZWJ1 (STXBP4) S99 Q12846 (STX4) unknown eFIP 24705589
Phosphorylation Q6ZWJ1 (STXBP4) S99 Q12846 (STX4) unknown eFIP 15753124


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S10 T10 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S163 Y163 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S208 F208 Biomuta DOID:4159 / skin cancer [ cosmic ]
S212 Y212 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S212 C212 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K233 N233 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K240 N240 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S252 F252 Biomuta DOID:4159 / skin cancer [ cosmic ]
S252 C252 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
C265 Y265 Biomuta DOID:1324 / lung cancer [ cosmic ]
T465 P465 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]