iPTMnet Report for Q6ZW31 (SYDE1)
Protein Information
| UniProt AC / UniProt ID | Q6ZW31 / SYDE1_HUMAN |
| Protein Name | Rho GTPase-activating protein SYDE1 |
| Gene Name | Name: SYDE1 |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q6ZW31 |
| PRO Name | Rho GTPase-activating protein SYDE1 (human) |
| Definition | A Rho GTPase-activating protein SYDE1 that is encoded in the genome of human. |
| Short Label | hSYDE1 |
| Category | organism-gene |
DAG ViewQ6ZW31 (SYDE1) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S75 | O-Glycosylation | score1 | GlyGen | 30620550 | ||
| K89 | Acetylation | score1 | PhosphoSitePlus | |||
| K89 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S224 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
| Y229 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S231 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 18669648 | ||
| S235 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 18669648 | ||
| S244 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 18669648 | ||
| T246 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S247 | Phosphorylation | score1 | PhosphoSitePlus | |||
| R307 | Methylation | score1 | PhosphoSitePlus | |||
| Y478 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T484 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K493 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S575 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
| S582 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S609 | Phosphorylation | score1 | PhosphoSitePlus | |||
| R640 | Methylation | score1 | PhosphoSitePlus | |||
| S645 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y675 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T679 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S681 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S683 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 18669648, 24275569 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| Y229 | Phosphorylation | score0 | HPRD | 18669648 | ||
| S231 | Phosphorylation | score0 | HPRD | 18669648 | ||
| S235 | Phosphorylation | score0 | HPRD | 18669648 | ||
| S244 | Phosphorylation | score0 | HPRD | 18669648 | ||
| T246 | Phosphorylation | score0 | HPRD | 18669648 | ||
| S247 | Phosphorylation | score0 | HPRD | 18669648 | ||
| S671 | Phosphorylation | score0 | HPRD | 18669648 | ||
| Y675 | Phosphorylation | score0 | HPRD | 18669648 | ||
| T679 | Phosphorylation | score0 | HPRD | 18669648 | ||
| S681 | Phosphorylation | score0 | HPRD | 18669648 | ||
| S683 | Phosphorylation | score0 | HPRD | 18669648 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S75 | C75 | Biomuta | DOID:263 / kidney cancer [ cosmic, icgc ] | |
| T246 | P246 | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] | |
| Y478 | N478 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
| T484 | I484 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
| R640 | Q640 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| R640 | * | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| T679 | M679 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| S683 | N683 | Biomuta | DOID:4159 / skin cancer [ cosmic ] |
