iPTMnet Report for Q6ZVD8 (PHLPP2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q6ZVD8 / PHLP2_HUMAN
Protein Name PH domain leucine-rich repeat-containing protein phosphatase 2
Gene Name Name: PHLPP2
Synonyms:KIAA0931,PHLPPL;
Organism Homo sapiens (Human)

PRO ID PR:Q6ZVD8
DAG View
PRO Name PH domain leucine-rich repeat-containing protein phosphatase 2 (human)
Definition A PH domain leucine-rich repeat-containing protein phosphatase 2 that is encoded in the genome of human.
Short Label hPHLPP2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q6ZVD8 (PHLPP2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S18 Phosphorylation PhosphoSitePlus
S52 Phosphorylation PhosphoSitePlus
S53 Phosphorylation PhosphoSitePlus
S54 Phosphorylation PhosphoSitePlus
S55 Phosphorylation PhosphoSitePlus
K302 Ubiquitination PhosphoSitePlus
K592 Ubiquitination PhosphoSitePlus
K663 Ubiquitination PhosphoSitePlus
K666 Ubiquitination PhosphoSitePlus
K679 Ubiquitination PhosphoSitePlus
K691 Ubiquitination PhosphoSitePlus
K1066 Methylation PhosphoSitePlus
S1119 Phosphorylation PhosphoSitePlus
S1143 Phosphorylation PhosphoSitePlus
S1149 Phosphorylation PhosphoSitePlus
S1182 Phosphorylation PhosphoSitePlus
S1210 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1213 Phosphorylation PhosphoSitePlus
S1220 Phosphorylation PhosphoSitePlus
S1229 Phosphorylation PhosphoSitePlus
S1231 Phosphorylation PhosphoSitePlus
T1259 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S18 C18 Biomuta DOID:1612 / breast cancer [ cosmic ]
S53 F53 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S55 C55 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K666 I666 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K1066 E1066 Biomuta DOID:263 / kidney cancer [ cosmic ]
K1066 M1066 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
K1066 N1066 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S1229 P1229 Biomuta DOID:4362 / cervical cancer [ cosmic ]
S1231 F1231 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S1231 A1231 Biomuta DOID:363 / uterine cancer [ icgc ]