iPTMnet Report for Q6ZV73 (FGD6)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q6ZV73 / FGD6_HUMAN
Protein Name FYVE, RhoGEF and PH domain-containing protein 6
Gene Name Name: FGD6
Synonyms:KIAA1362,ZFYVE24;
Organism Homo sapiens (Human)

PRO ID PR:Q6ZV73
DAG View
PRO Name FYVE, RhoGEF and PH domain-containing protein 6 (human)
Definition A FYVE, RhoGEF and PH domain-containing protein 6 that is encoded in the genome of human.
Short Label hFGD6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q6ZV73 (FGD6) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S3 Phosphorylation PhosphoSitePlus
S62 Phosphorylation PhosphoSitePlus
S70 Phosphorylation PhosphoSitePlus
C95 Methylation IEDB 31844290
Y105 Phosphorylation PhosphoSitePlus
Y162 Phosphorylation PhosphoSitePlus
K165 Acetylation PhosphoSitePlus
S177 Phosphorylation PhosphoSitePlus
S196 Phosphorylation PhosphoSitePlus
S205 Phosphorylation PhosphoSitePlus
S226 Phosphorylation PhosphoSitePlus
S228 Phosphorylation PhosphoSitePlus
S231 Phosphorylation PhosphoSitePlus   UniProt 23186163
S281 Phosphorylation PhosphoSitePlus
S286 Phosphorylation PhosphoSitePlus
S410 Phosphorylation PhosphoSitePlus
S417 Phosphorylation PhosphoSitePlus
S454 Phosphorylation PhosphoSitePlus
K460 Methylation PhosphoSitePlus
S491 Phosphorylation PhosphoSitePlus
S503 Phosphorylation PhosphoSitePlus
K511 Methylation PhosphoSitePlus
K512 Methylation PhosphoSitePlus
S515 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692
S552 Phosphorylation PhosphoSitePlus
S553 Phosphorylation PhosphoSitePlus
S554 Phosphorylation PhosphoSitePlus   UniProt 23186163
S605 Phosphorylation PhosphoSitePlus
S607 Phosphorylation PhosphoSitePlus
K650 Ubiquitination PhosphoSitePlus
S651 Phosphorylation PhosphoSitePlus
S664 Phosphorylation PhosphoSitePlus
K683 Ubiquitination PhosphoSitePlus
Y691 Phosphorylation PhosphoSitePlus
S692 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 18669648
T693 Phosphorylation PhosphoSitePlus
Y696 Phosphorylation PhosphoSitePlus
S697 Phosphorylation PhosphoSitePlus
S700 Phosphorylation PhosphoSitePlus
S707 Phosphorylation PhosphoSitePlus
S721 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692, ...20068231
Y737 Phosphorylation PhosphoSitePlus
S739 Phosphorylation PhosphoSitePlus
Y748 Phosphorylation PhosphoSitePlus
Y754 Phosphorylation PhosphoSitePlus
Y760 Phosphorylation PhosphoSitePlus
K869 Acetylation PhosphoSitePlus
K871 Acetylation PhosphoSitePlus
Y962 Phosphorylation PhosphoSitePlus
Y966 Phosphorylation PhosphoSitePlus
S967 Phosphorylation PhosphoSitePlus
T968 Phosphorylation PhosphoSitePlus
Y969 Phosphorylation PhosphoSitePlus
S1197 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163
S1203 Phosphorylation PhosphoSitePlus
S1210 Phosphorylation PhosphoSitePlus
T1238 Phosphorylation PhosphoSitePlus
S1288 Phosphorylation PhosphoSitePlus
S1293 Phosphorylation PhosphoSitePlus
S1299 Phosphorylation PhosphoSitePlus
S1302 Phosphorylation PhosphoSitePlus
S1305 Phosphorylation PhosphoSitePlus
S1313 Phosphorylation PhosphoSitePlus
K1395 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S177 Phosphorylation HPRD 19664994
S515 Phosphorylation HPRD 18669648
S632 Phosphorylation HPRD 20068231
S642 Phosphorylation HPRD 20068231
S692 Phosphorylation HPRD 18669648, 19664995
S721 Phosphorylation HPRD 18669648, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S70 L70 Biomuta DOID:4159 / skin cancer [ cosmic ]
S70 P70 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S205 I205 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S226 L226 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S231 G231 Biomuta DOID:1324 / lung cancer [ cosmic ]
S281 I281 Biomuta DOID:363 / uterine cancer [ icgc ]
S410 F410 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S417 F417 Biomuta DOID:3565 / meningioma [ cosmic ]
S491 F491 Biomuta DOID:4159 / skin cancer [ cosmic, icgc, tcga ]
S491 Y491 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
S491 C491 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S605 L605 Biomuta DOID:4159 / skin cancer [ cosmic ]
S642 I642 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S664 T664 Biomuta DOID:1324 / lung cancer [ cosmic ]
S707 Y707 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S721 F721 Biomuta DOID:4159 / skin cancer [ cosmic ]
K871 N871 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S1288 F1288 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1299 P1299 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S1305 P1305 Biomuta DOID:3571 / liver cancer [ cosmic ]