iPTMnet Report for Q6ZUM4 (ARHGAP27)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q6ZUM4 / RHG27_HUMAN
Protein Name Rho GTPase-activating protein 27
Gene Name Name: ARHGAP27
Synonyms:CAMGAP1,SH3D20;ORFNames:PP905;
Organism Homo sapiens (Human)

PRO ID PR:Q6ZUM4
DAG View
PRO Name Rho GTPase-activating protein 27 (human)
Definition A Rho GTPase-activating protein 27 that is encoded in the genome of human.
Short Label hARHGAP27
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q6ZUM4 (ARHGAP27) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S41 Phosphorylation PhosphoSitePlus
S84 Phosphorylation PhosphoSitePlus
T130 Phosphorylation PhosphoSitePlus
S156 Phosphorylation PhosphoSitePlus
S182 Phosphorylation PhosphoSitePlus
S249 Phosphorylation PhosphoSitePlus   UniProt 24275569
Y408 Phosphorylation PhosphoSitePlus
S451 Phosphorylation PhosphoSitePlus
S455 Phosphorylation PhosphoSitePlus
S456 Phosphorylation PhosphoSitePlus
T461 Phosphorylation PhosphoSitePlus
S466 Phosphorylation PhosphoSitePlus   UniProt 24275569
S481 Phosphorylation PhosphoSitePlus
S486 Phosphorylation PhosphoSitePlus
K499 Methylation PhosphoSitePlus
K536 Acetylation PhosphoSitePlus
K551 Ubiquitination PhosphoSitePlus
S575 Phosphorylation PhosphoSitePlus
S632 Phosphorylation PhosphoSitePlus
S633 Phosphorylation PhosphoSitePlus
S638 Phosphorylation PhosphoSitePlus
K666 Ubiquitination PhosphoSitePlus
T680 Phosphorylation PhosphoSitePlus
S683 Phosphorylation PhosphoSitePlus
K743 Ubiquitination PhosphoSitePlus
S786 O-Glycosylation GlyGen 30379171, 29351928
T821 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S451 R451 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
S451 N451 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S455 T455 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
K499 Q499 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K536 E536 Biomuta DOID:363 / uterine cancer [ cosmic ]
S632 L632 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
S683 L683 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S786 L786 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S786 P786 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]