iPTMnet Report for Q6ZU35 (CRACD)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q6ZU35 / CRACD_HUMAN
Protein Name Capping protein-inhibiting regulator of actin dynamics
Gene Name Name: CRACD
Synonyms:CRAD;
Organism Homo sapiens (Human)

PRO ID PR:Q6ZU35
DAG View
PRO Name capping protein-inhibiting regulator of actin dynamics (human)
Definition A capping protein-inhibiting regulator of actin dynamics that is encoded in the genome of human.
Short Label hCRACD
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q6ZU35 (CRACD) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S53 Phosphorylation PhosphoSitePlus
T99 Phosphorylation HPRD   PhosphoSitePlus 18452278
S101 Phosphorylation HPRD   PhosphoSitePlus 18452278
S104 Phosphorylation PhosphoSitePlus
S132 Phosphorylation HPRD   PhosphoSitePlus 18669648
T136 Phosphorylation PhosphoSitePlus
K158 Methylation PhosphoSitePlus
K160 Methylation PhosphoSitePlus
K166 Methylation PhosphoSitePlus
Y227 Phosphorylation PhosphoSitePlus
S420 Phosphorylation PhosphoSitePlus   UniProt 24275569
S556 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
T559 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18669648, 20068231
T564 Phosphorylation PhosphoSitePlus
K574 Acetylation PhosphoSitePlus
S579 Phosphorylation PhosphoSitePlus
S681 Phosphorylation PhosphoSitePlus
T698 Phosphorylation PhosphoSitePlus
T712 Phosphorylation PhosphoSitePlus
S739 Phosphorylation PhosphoSitePlus
T740 Phosphorylation PhosphoSitePlus
T757 Phosphorylation PhosphoSitePlus
S843 Phosphorylation PhosphoSitePlus
S873 Phosphorylation PhosphoSitePlus
S874 Phosphorylation HPRD   PhosphoSitePlus 20068231
T875 Phosphorylation PhosphoSitePlus
S878 Phosphorylation PhosphoSitePlus
S920 Phosphorylation PhosphoSitePlus
S925 Phosphorylation PhosphoSitePlus
K954 Acetylation PhosphoSitePlus
T968 Phosphorylation HPRD   PhosphoSitePlus 18669648, 20068231
S969 Phosphorylation HPRD   PhosphoSitePlus 20068231
T971 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 18669648, 21406692, ...20068231
S975 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 18669648, 21406692, ...20068231
S978 Phosphorylation HPRD   PhosphoSitePlus 20068231
S1017 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1042 Phosphorylation HPRD   PhosphoSitePlus 19413330
S1072 Phosphorylation PhosphoSitePlus
S1076 Phosphorylation HPRD   PhosphoSitePlus 20068231
S1139 Phosphorylation PhosphoSitePlus
T1148 Phosphorylation HPRD   PhosphoSitePlus 18452278
T1158 Phosphorylation HPRD   PhosphoSitePlus 18452278
S1161 Phosphorylation HPRD   PhosphoSitePlus 18452278
S1201 Phosphorylation PhosphoSitePlus
S1226 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S104 T104 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
T136 N136 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K166 * Biomuta DOID:1324 / lung cancer [ cosmic ]
T559 K559 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
T559 M559 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T698 A698 Biomuta DOID:2021 / placenta cancer [ cosmic ]
T740 M740 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S873 I873 Biomuta DOID:363 / uterine cancer [ icgc ]
T875 N875 Biomuta DOID:1324 / lung cancer [ cosmic ]
T875 I875 Biomuta DOID:4159 / skin cancer [ cosmic ]
S878 G878 Biomuta DOID:1324 / lung cancer [ cosmic ]
S920 Y920 Biomuta DOID:1324 / lung cancer [ cosmic ]
S975 P975 Biomuta DOID:184 / bone cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
S1072 F1072 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
S1076 C1076 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1139 R1139 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1161 T1161 Biomuta DOID:184 / bone cancer [ cosmic ]