iPTMnet Report for Q6ZNL6 (FGD5)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q6ZNL6 / FGD5_HUMAN
Protein Name FYVE, RhoGEF and PH domain-containing protein 5
Gene Name Name: FGD5
Synonyms:ZFYVE23;
Organism Homo sapiens (Human)

PRO ID PR:Q6ZNL6
DAG View
PRO Name FYVE, RhoGEF and PH domain-containing protein 5 (human)
Definition A FYVE, RhoGEF and PH domain-containing protein 5 that is encoded in the genome of human.
Short Label hFGD5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q6ZNL6 (FGD5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S30 Phosphorylation PhosphoSitePlus
S52 Phosphorylation PhosphoSitePlus
S57 Phosphorylation PhosphoSitePlus
S59 Phosphorylation PhosphoSitePlus
Y65 Phosphorylation PhosphoSitePlus
T522 Phosphorylation PhosphoSitePlus
S552 Phosphorylation PhosphoSitePlus
S632 Phosphorylation PhosphoSitePlus
S633 Phosphorylation PhosphoSitePlus
S640 Phosphorylation PhosphoSitePlus
S642 Phosphorylation PhosphoSitePlus
Y646 Phosphorylation PhosphoSitePlus
K649 Acetylation PhosphoSitePlus
K650 Acetylation PhosphoSitePlus
K654 Acetylation PhosphoSitePlus
T660 Phosphorylation PhosphoSitePlus
S699 O-Glycosylation GlyGen 31492838
S699 Phosphorylation PhosphoSitePlus
S701 O-Glycosylation GlyGen 31492838
S703 O-Glycosylation GlyGen 31492838
S703 Phosphorylation PhosphoSitePlus
S716 Phosphorylation PhosphoSitePlus
S718 Phosphorylation PhosphoSitePlus
K729 Acetylation PhosphoSitePlus
S740 Phosphorylation PhosphoSitePlus
S744 Phosphorylation PhosphoSitePlus
S749 Phosphorylation PhosphoSitePlus
T759 Phosphorylation PhosphoSitePlus
S765 Phosphorylation PhosphoSitePlus
T771 Phosphorylation PhosphoSitePlus
Y774 Phosphorylation PhosphoSitePlus
Y784 Phosphorylation PhosphoSitePlus
Y820 Phosphorylation PhosphoSitePlus
Y844 Phosphorylation PhosphoSitePlus
S870 Phosphorylation PhosphoSitePlus
S871 Phosphorylation PhosphoSitePlus
S878 Phosphorylation PhosphoSitePlus
K975 Ubiquitination PhosphoSitePlus
S1029 Phosphorylation PhosphoSitePlus
K1033 Ubiquitination PhosphoSitePlus
K1116 Ubiquitination PhosphoSitePlus
K1122 Ubiquitination PhosphoSitePlus
Y1142 Phosphorylation PhosphoSitePlus
K1154 Ubiquitination PhosphoSitePlus
T1156 Phosphorylation PhosphoSitePlus
K1163 Ubiquitination PhosphoSitePlus
Y1199 Phosphorylation PhosphoSitePlus
S1221 Phosphorylation PhosphoSitePlus
K1291 Acetylation PhosphoSitePlus
K1301 Methylation PhosphoSitePlus
K1301 Ubiquitination PhosphoSitePlus
S1317 Phosphorylation PhosphoSitePlus
S1367 Phosphorylation PhosphoSitePlus
S1371 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S749 Phosphorylation HPRD 19664995
T759 Phosphorylation HPRD 19664995


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S57 C57 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S59 L59 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ]
Y65 C65 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T522 K522 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K649 N649 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K650 N650 Biomuta DOID:4159 / skin cancer [ cosmic ]
K654 N654 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T660 M660 Biomuta DOID:1319 / brain cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic ]
S718 F718 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T759 S759 Biomuta DOID:3571 / liver cancer [ cosmic ]
S765 F765 Biomuta [ cosmic ]
Y784 N784 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
Y820 C820 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S871 L871 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S878 L878 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1029 N1029 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S1029 G1029 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S1371 I1371 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]