iPTMnet Report for Q6ZNA4 (RNF111)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q6ZNA4 / RN111_HUMAN
Protein Name E3 ubiquitin-protein ligase Arkadia
Gene Name Name: RNF111
Organism Homo sapiens (Human)

PRO ID PR:Q6ZNA4
DAG View
PRO Name E3 ubiquitin-protein ligase Arkadia (human)
Definition An E3 ubiquitin-protein ligase Arkadia that is encoded in the genome of human.
Short Label hRNF111
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q6ZNA4 (RNF111) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K19 Sumoylation PhosphoSitePlus
S20 Phosphorylation PhosphoSitePlus
S24 Phosphorylation PhosphoSitePlus
K28 Ubiquitination PhosphoSitePlus
K34 Sumoylation PhosphoSitePlus
K34 Ubiquitination PhosphoSitePlus
K47 Sumoylation PhosphoSitePlus
K47 Ubiquitination PhosphoSitePlus
K73 Sumoylation PhosphoSitePlus
K73 Ubiquitination PhosphoSitePlus
K87 Ubiquitination PhosphoSitePlus
S97 Phosphorylation PhosphoSitePlus
K173 Sumoylation PhosphoSitePlus
K173 Ubiquitination PhosphoSitePlus
K218 Ubiquitination PhosphoSitePlus
S339 Phosphorylation PhosphoSitePlus
S354 Phosphorylation PhosphoSitePlus
S579 Phosphorylation PhosphoSitePlus
Y783 Phosphorylation PhosphoSitePlus
R861 Methylation PhosphoSitePlus
R895 Methylation PhosphoSitePlus
S898 Phosphorylation PhosphoSitePlus
T901 Phosphorylation PhosphoSitePlus
K927 Sumoylation PhosphoSitePlus
K927 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K87 Q87 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S339 L339 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S354 F354 Biomuta DOID:1319 / brain cancer [ cosmic ]
R861 C861 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]
R861 H861 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
R895 C895 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
R895 H895 Biomuta DOID:363 / uterine cancer [ icgc ]