iPTMnet Report for Q6ZN54 (DEF8)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q6ZN54 / DEFI8_HUMAN
Protein Name Differentially expressed in FDCP 8 homolog
Gene Name Name: DEF8
Organism Homo sapiens (Human)

PRO ID PR:Q6ZN54
DAG View
PRO Name differentially expressed in FDCP 8 homolog (human)
Definition A differentially expressed in FDCP 8 that is encoded in the genome of human.
Short Label hDEF8
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q6ZN54 (DEF8) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378
T54 Phosphorylation PhosphoSitePlus
Y64 Phosphorylation PhosphoSitePlus
K67 Ubiquitination PhosphoSitePlus
K81 Ubiquitination PhosphoSitePlus
K154 Ubiquitination PhosphoSitePlus
K166 Ubiquitination PhosphoSitePlus
K180 Ubiquitination PhosphoSitePlus
K185 Ubiquitination PhosphoSitePlus
S207 Phosphorylation PhosphoSitePlus
C281 Methylation IEDB 31844290
K435 Acetylation PhosphoSitePlus
K435 Ubiquitination PhosphoSitePlus
K491 Ubiquitination PhosphoSitePlus
K499 Ubiquitination PhosphoSitePlus
S501 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T54 A54 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K67 E67 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]