iPTMnet Report for Q6ZN16 (MAP3K15)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q6ZN16 / M3K15_HUMAN
Protein Name Mitogen-activated protein kinase kinase kinase 15
Gene Name Name: MAP3K15
Synonyms:ASK3;
Organism Homo sapiens (Human)

PRO ID PR:Q6ZN16
DAG View
PRO Name mitogen-activated protein kinase kinase kinase 15 (human)
Definition A mitogen-activated protein kinase kinase kinase 15 that is encoded in the genome of human.
Short Label hMAP3K15
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q6ZN16 (MAP3K15) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S71 Phosphorylation PhosphoSitePlus
Y298 Phosphorylation PhosphoSitePlus
S432 Phosphorylation PhosphoSitePlus
Y446 Phosphorylation PhosphoSitePlus
S484 Phosphorylation PhosphoSitePlus
S608 Phosphorylation PhosphoSitePlus
T609 Phosphorylation PhosphoSitePlus
K681 Ubiquitination PhosphoSitePlus
K751 Methylation PhosphoSitePlus
Y763 Phosphorylation PhosphoSitePlus
K797 Ubiquitination PhosphoSitePlus
T808 Phosphorylation PhosphoSitePlus
S994 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1009 Phosphorylation IEDB 35494241
Y1201 Phosphorylation PhosphoSitePlus
S1269 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S432 T432 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S608 F608 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K751 T751 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10283 / prostate cancer [ cosmic ]
Y763 H763 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1269 L1269 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic ]