iPTMnet Report for Q6ZMG9 (CERS6)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q6ZMG9 / CERS6_HUMAN
Protein Name Ceramide synthase 6
Gene Name Name: CERS6
Synonyms:LASS6;
Organism Homo sapiens (Human)

PRO ID PR:Q6ZMG9
DAG View
PRO Name ceramide synthase 6 (human)
Definition A ceramide synthase 6 that is encoded in the genome of human.
Short Label hCERS6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q6ZMG9 (CERS6) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
N18 N-Glycosylation GlyGen   UniProt 29741879, 19159218, 24190977
T91 Phosphorylation PhosphoSitePlus
K92 Ubiquitination PhosphoSitePlus
K97 Ubiquitination PhosphoSitePlus
K104 Ubiquitination PhosphoSitePlus
R111 Methylation PhosphoSitePlus
K125 Ubiquitination PhosphoSitePlus
K155 Ubiquitination PhosphoSitePlus
S341 Phosphorylation PhosphoSitePlus
S345 Phosphorylation PhosphoSitePlus
S346 Phosphorylation PhosphoSitePlus
S347 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R111 Q111 Biomuta DOID:363 / uterine cancer [ icgc ]
R111 * Biomuta DOID:363 / uterine cancer [ cosmic ]
S341 T341 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S346 G346 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S347 A347 Biomuta DOID:1324 / lung cancer [ cosmic ]