iPTMnet Report for Q6YHU6 (THADA)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q6YHU6 / THADA_HUMAN
Protein Name tRNA (32-2'-O)-methyltransferase regulator THADA
Gene Name Name: THADA
Synonyms:GITA,KIAA1767;
Organism Homo sapiens (Human)

PRO ID PR:Q6YHU6
DAG View
PRO Name thyroid adenoma-associated protein (human)
Definition A thyroid adenoma-associated protein that is encoded in the genome of human.
Short Label hTHADA
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q6YHU6 (THADA) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K25 Ubiquitination PhosphoSitePlus
K64 Ubiquitination PhosphoSitePlus
S77 Phosphorylation PhosphoSitePlus
K136 Ubiquitination PhosphoSitePlus
S169 O-Glycosylation GlyGen 35254053
S285 Phosphorylation PhosphoSitePlus
S344 Phosphorylation PhosphoSitePlus
S387 Phosphorylation PhosphoSitePlus
Y544 Phosphorylation PhosphoSitePlus
Y563 Phosphorylation PhosphoSitePlus
K566 Ubiquitination PhosphoSitePlus
K575 Ubiquitination PhosphoSitePlus
T576 Phosphorylation PhosphoSitePlus
S581 Phosphorylation PhosphoSitePlus
K627 Ubiquitination PhosphoSitePlus
C691 Methylation IEDB 31844290
S696 Phosphorylation PhosphoSitePlus
S697 Phosphorylation PhosphoSitePlus
Y701 Phosphorylation PhosphoSitePlus
K702 Ubiquitination PhosphoSitePlus
K709 Ubiquitination PhosphoSitePlus
K718 Ubiquitination PhosphoSitePlus
S943 Phosphorylation PhosphoSitePlus
S964 Phosphorylation PhosphoSitePlus
T980 Phosphorylation PhosphoSitePlus
Y1003 Phosphorylation PhosphoSitePlus
K1008 Ubiquitination PhosphoSitePlus
K1011 Ubiquitination PhosphoSitePlus
S1015 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1024 Phosphorylation PhosphoSitePlus   UniProt 20068231
S1031 Phosphorylation PhosphoSitePlus
K1035 Ubiquitination PhosphoSitePlus
K1037 Acetylation PhosphoSitePlus
K1040 Acetylation PhosphoSitePlus
K1154 Ubiquitination PhosphoSitePlus
S1161 Phosphorylation PhosphoSitePlus   UniProt 18691976
T1221 Phosphorylation PhosphoSitePlus
Y1230 Phosphorylation PhosphoSitePlus
S1258 Phosphorylation PhosphoSitePlus
T1262 Phosphorylation PhosphoSitePlus
S1275 Phosphorylation PhosphoSitePlus
Y1293 Phosphorylation IEDB 35494241
K1440 Ubiquitination PhosphoSitePlus
C1452 Methylation IEDB 31844290
K1578 Ubiquitination PhosphoSitePlus
K1659 Ubiquitination PhosphoSitePlus
T1667 Phosphorylation PhosphoSitePlus
K1897 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S943 Phosphorylation HPRD 20068231
S1024 Phosphorylation HPRD 20068231
S1031 Phosphorylation HPRD 18691976
S1161 Phosphorylation HPRD 18691976
T1221 Phosphorylation HPRD 20068231
Y1230 Phosphorylation HPRD 20068231
S1339 Phosphorylation HPRD 20068231
S1340 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S77 G77 Biomuta DOID:263 / kidney cancer [ cosmic ]
K136 T136 Biomuta DOID:3571 / liver cancer [ cosmic ]
Y563 H563 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y563 C563 Biomuta DOID:1324 / lung cancer [ cosmic ]
S696 I696 Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
Y701 F701 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K702 Q702 Biomuta DOID:363 / uterine cancer [ icgc ]
S943 R943 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
K1008 N1008 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K1008 E1008 Biomuta DOID:1612 / breast cancer [ cosmic ]
T1221 M1221 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]