iPTMnet Report for Q6Y7W6 (GIGYF2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q6Y7W6 / GGYF2_HUMAN
Protein Name GRB10-interacting GYF protein 2
Gene Name Name: GIGYF2
Synonyms:KIAA0642;
Organism Homo sapiens (Human)

PRO ID PR:Q6Y7W6
DAG View
PRO Name GRB10-interacting GYF protein 2 (human)
Definition A GRB10-interacting GYF protein 2 that is encoded in the genome of human.
Short Label hGIGYF2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q6Y7W6 (GIGYF2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22223895
S19 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S20 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S23 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T25 Phosphorylation PhosphoSitePlus
S26 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 16964243, ...18220336, 18669648, 24275569, 19690332, 20068231, 17081983
S30 Phosphorylation P28482 (MAPK1) neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 22028470, 23186163, ...17081983, 18220336, 18669648, 19690332
K35 Ubiquitination PhosphoSitePlus
K37 Methylation PhosphoSitePlus
K37 Ubiquitination PhosphoSitePlus
K57 Ubiquitination PhosphoSitePlus
T85 Phosphorylation PhosphoSitePlus
S98 O-Glycosylation GlyGen 28510447, 34019948, 30379171, ...34725712, 30059200, 28657654, 30620550, 35132862, 31492838, 32119511, 35254053, 34229054, 29237092
S98 Phosphorylation PhosphoSitePlus
T105 Phosphorylation PhosphoSitePlus
R107 Methylation PhosphoSitePlus
T112 Phosphorylation PhosphoSitePlus
R118 Methylation PhosphoSitePlus
R120 Methylation PhosphoSitePlus
S139 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163, 19690332
R149 Methylation PhosphoSitePlus
R153 Methylation PhosphoSitePlus
R157 Methylation PhosphoSitePlus
S158 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S160 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
R164 Methylation PhosphoSitePlus
T188 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
S189 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S201 Phosphorylation PhosphoSitePlus
S236 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17081983, 18669648, ...24275569, 20068231
S242 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
Y268 Phosphorylation PhosphoSitePlus
S273 Phosphorylation PhosphoSitePlus
S275 Phosphorylation PhosphoSitePlus
S302 Phosphorylation PhosphoSitePlus
S303 Phosphorylation PhosphoSitePlus
S335 Phosphorylation PhosphoSitePlus
S337 Phosphorylation PhosphoSitePlus
S340 Phosphorylation PhosphoSitePlus
T370 Phosphorylation PhosphoSitePlus
T373 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S374 O-Glycosylation GlyGen 28510447, 34019948, 30379171, ...34725712, 30059200, 28657654, 30620550, 35132862, 31492838, 32119511, 35254053, 34229054, 29237092
S374 Phosphorylation PhosphoSitePlus
S375 Phosphorylation PhosphoSitePlus
S376 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S377 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T382 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 18669648, ...19690332, 20068231
S384 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 18220336
S388 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 24275569, 18220336
S417 Phosphorylation PhosphoSitePlus
K497 Ubiquitination PhosphoSitePlus
S505 Phosphorylation PhosphoSitePlus
K515 Ubiquitination PhosphoSitePlus
K522 Ubiquitination PhosphoSitePlus
S525 Phosphorylation PhosphoSitePlus
K535 Ubiquitination PhosphoSitePlus
K585 Ubiquitination PhosphoSitePlus
S593 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
S649 Phosphorylation PhosphoSitePlus
S650 Phosphorylation PhosphoSitePlus
T665 Phosphorylation PhosphoSitePlus
K667 Ubiquitination PhosphoSitePlus
R669 Methylation PhosphoSitePlus
S671 Phosphorylation PhosphoSitePlus
S678 O-Glycosylation GlyGen 28510447, 34019948, 30379171, ...34725712, 30059200, 28657654, 30620550, 35132862, 31492838, 32119511, 35254053, 34229054, 29237092
T680 O-Glycosylation GlyGen 32938750, 35254053, 30379171, ...34725712, 28510447, 34019948, 28657654, 30059200, 35132862, 31492838, 32119511, 30620550, 34229054, 29237092
K731 Ubiquitination PhosphoSitePlus
K951 Ubiquitination PhosphoSitePlus
K973 Ubiquitination PhosphoSitePlus
K985 Ubiquitination PhosphoSitePlus
S993 O-Glycosylation GlyGen 28510447, 34019948, 30379171, ...34725712, 30059200, 28657654, 30620550, 35132862, 31492838, 32119511, 35254053, 34229054, 29237092
S993 Phosphorylation PhosphoSitePlus   UniProt 23186163
K994 Ubiquitination PhosphoSitePlus
K1000 Ubiquitination PhosphoSitePlus
K1015 Ubiquitination PhosphoSitePlus
T1033 Phosphorylation PhosphoSitePlus
S1035 Phosphorylation PhosphoSitePlus
T1039 Phosphorylation PhosphoSitePlus
K1084 Ubiquitination PhosphoSitePlus
K1103 Ubiquitination PhosphoSitePlus
K1120 Ubiquitination PhosphoSitePlus
K1123 Ubiquitination PhosphoSitePlus
K1185 Ubiquitination PhosphoSitePlus
K1189 Ubiquitination PhosphoSitePlus
S1275 Phosphorylation PhosphoSitePlus
S1284 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y1299 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S19 Phosphorylation HPRD 19413330, 19651622, 18669648, ...16964243
S20 Phosphorylation HPRD 19413330, 18669648, 19415658, ...20068231
S23 Phosphorylation HPRD 18669648, 19415658
T25 Phosphorylation HPRD 19651622, 18691976, 17081983, ...20068231, 19664995
S26 Phosphorylation HPRD 19413330, 18691976, 18212344, ...20058876, 15302935, 19664995, 18452278, 19651622, 18669648, 17693683, 19415658, 20068231, 16964243
S30 Phosphorylation HPRD 19413330, 18691976, 17081983, ...16964243, 19664995, 19651622, 18669648, 19415658, 20068231, 18212344
T85 Phosphorylation HPRD 20068231
S158 Phosphorylation HPRD 19651622, 17081983
S160 Phosphorylation HPRD 18669648, 16964243, 20068231, ...18212344
S189 Phosphorylation HPRD 18669648, 20068231
S201 Phosphorylation HPRD 19651622, 16964243
S236 Phosphorylation HPRD 18691976, 17081983, 19651622, ...18669648, 20166139, 20068231
S242 Phosphorylation HPRD 17081983, 20068231
T373 Phosphorylation HPRD 18669648, 20068231
S376 Phosphorylation HPRD 19413330, 18669648, 18491316, ...19664995, 20068231
S377 Phosphorylation HPRD 18669648, 18491316, 18452278
T382 Phosphorylation HPRD 19413330, 18691976, 17081983, ...19664995, 18452278, 19651622, 18669648, 20068231
S384 Phosphorylation HPRD 18669648, 19664995, 18452278
S388 Phosphorylation HPRD 18452278
S593 Phosphorylation HPRD 18669648, 20068231
S650 Phosphorylation HPRD 20068231
S1275 Phosphorylation HPRD 20068231
S1280 Phosphorylation HPRD 20068231
S1284 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S19 Phosphorylation phospho.ELM 18669648
S20 Phosphorylation phospho.ELM 18669648
S23 Phosphorylation phospho.ELM 18669648
S26 Phosphorylation phospho.ELM 18669648, 18220336
S30 Phosphorylation P06493 (CDK1) , P24941 (CDK2) phospho.ELM   PhosphoSitePlus 18669648, 18234856, 18847512, ...18220336
S160 Phosphorylation phospho.ELM 18669648
T403 Phosphorylation PhosphoSitePlus
S614 Phosphorylation P24941 (CDK2) PhosphoSitePlus 18847512
Site PTM Type PTM Enzyme Score Source PMID
S189 Phosphorylation PhosphoSitePlus
S236 Phosphorylation PhosphoSitePlus
T364 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S30 Y30 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
R107 Q107 Biomuta [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
R107 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R120 * Biomuta DOID:10283 / prostate cancer [ cosmic ]
S139 R139 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
R149 Q149 Biomuta DOID:10534 / stomach cancer [ cosmic ]
R149 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S158 L158 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
S160 I160 Biomuta DOID:363 / uterine cancer [ cosmic ]
S273 C273 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S337 F337 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K497 N497 Biomuta DOID:363 / uterine cancer [ icgc ]
S678 L678 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K731 N731 Biomuta DOID:1324 / lung cancer [ icgc ]
S993 R993 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S993 T993 Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic, icgc ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
T1033 M1033 Biomuta DOID:363 / uterine cancer [ icgc ]
T1039 S1039 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1280 L1280 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S1284 * Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y1299 * Biomuta DOID:1612 / breast cancer [ cosmic ]