iPTMnet Report Q6WCQ1 MPRIP

Protein Information

UniProt AC / UniProt ID	Q6WCQ1 / MPRIP_HUMAN
Protein Name	Myosin phosphatase Rho-interacting protein
Gene Name	Name: MPRIP Synonyms:KIAA0864,MRIP,RHOIP3;
Organism	Homo sapiens (Human)

PRO ID	PR:Q6WCQ1 DAG View
PRO Name	myosin phosphatase Rho-interacting protein (human)
Definition	A myosin phosphatase Rho-interacting protein that is encoded in the genome of human.
Short Label	hMPRIP
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q6WCQ1 (MPRIP) as Substrate

Expanded View

Site	PTM Type	Score	Source	PMID
K5	Ubiquitination	score1	PhosphoSitePlus
T166	Phosphorylation	score1	PhosphoSitePlus
T178	O-Glycosylation	score1	GlyGen	30379171, 31492838, 34019948, ...28657654, 35254053
S179	O-Glycosylation	score1	GlyGen	30379171, 31492838, 34019948, ...28657654, 35254053
S181	Phosphorylation	score1	PhosphoSitePlus
S182	Phosphorylation	score1	PhosphoSitePlus
S183	Phosphorylation	score1	PhosphoSitePlus
S184	Phosphorylation	score1	PhosphoSitePlus
S192	Phosphorylation	score2	PhosphoSitePlus UniProt	18669648
T210	Phosphorylation	score1	PhosphoSitePlus
S217	Phosphorylation	score2	PhosphoSitePlus UniProt	24275569
S218	Phosphorylation	score1	PhosphoSitePlus
S220	Phosphorylation	score2	PhosphoSitePlus UniProt	18669648, 20068231, 24275569
S224	Phosphorylation	score2	PhosphoSitePlus UniProt	18669648, 23186163
S226	Phosphorylation	score2	PhosphoSitePlus UniProt	18669648, 24275569
S228	Phosphorylation	score1	PhosphoSitePlus
S265	Phosphorylation	score2	PhosphoSitePlus UniProt	23186163
Y267	Phosphorylation	score1	PhosphoSitePlus
S269	Phosphorylation	score2	PhosphoSitePlus UniProt	23186163, 20068231
S289	Phosphorylation	score2	PhosphoSitePlus UniProt	18669648, 19690332, 20068231
S292	Phosphorylation	score2	PhosphoSitePlus UniProt	18669648
S294	Phosphorylation	score1	PhosphoSitePlus
T295	Phosphorylation	score2	PhosphoSitePlus UniProt	18669648
S301	Phosphorylation	score1	PhosphoSitePlus
K306	Ubiquitination	score1	PhosphoSitePlus
S326	Phosphorylation	score2	PhosphoSitePlus UniProt	23186163
S329	Phosphorylation	score1	PhosphoSitePlus
T348	Phosphorylation	score2	PhosphoSitePlus UniProt	24275569
S360	Phosphorylation	score1	PhosphoSitePlus
S362	Phosphorylation	score2	PhosphoSitePlus UniProt	18669648, 20068231, 24275569
S365	Phosphorylation	score2	PhosphoSitePlus UniProt	18669648, 20068231, 24275569
S372	Phosphorylation	score1	PhosphoSitePlus
S377	Phosphorylation	score1	PhosphoSitePlus
T378	Phosphorylation	score1	PhosphoSitePlus
T383	Phosphorylation	score1	PhosphoSitePlus
K390	Ubiquitination	score1	PhosphoSitePlus
K396	Ubiquitination	score1	PhosphoSitePlus
Y450	Phosphorylation	score1	PhosphoSitePlus
S493	Phosphorylation	score2	PhosphoSitePlus UniProt	23186163
S501	Phosphorylation	score1	PhosphoSitePlus
S504	Phosphorylation	score1	PhosphoSitePlus
K527	Ubiquitination	score1	PhosphoSitePlus
S540	Phosphorylation	score1	PhosphoSitePlus
T542	Phosphorylation	score1	PhosphoSitePlus
T602	Phosphorylation	score1	PhosphoSitePlus
S619	Phosphorylation	score2	PhosphoSitePlus UniProt	18669648, 23186163, 17081983, ...20068231
S625	Phosphorylation	score1	PhosphoSitePlus
T646	Phosphorylation	score2	PhosphoSitePlus UniProt	23186163
S662	Phosphorylation	score1	PhosphoSitePlus
S663	Phosphorylation	score2	PhosphoSitePlus UniProt	23186163
K681	Ubiquitination	score1	PhosphoSitePlus
K688	Ubiquitination	score1	PhosphoSitePlus
S691	Phosphorylation	score1	PhosphoSitePlus
S713	Phosphorylation	score1	PhosphoSitePlus
Y718	Phosphorylation	score1	PhosphoSitePlus
S800	Phosphorylation	score2	PhosphoSitePlus UniProt	24275569
S815	Phosphorylation	score1	PhosphoSitePlus
S891	Phosphorylation	score2	PhosphoSitePlus UniProt	18669648, 23186163, 20068231, ...24275569
Y915	Phosphorylation	score1	PhosphoSitePlus
K917	Ubiquitination	score1	PhosphoSitePlus
S921	O-Glycosylation	score1	GlyGen	30379171, 31492838, 34019948, ...28657654, 35254053
S921	Phosphorylation	score1	PhosphoSitePlus
S922	O-Glycosylation	score1	GlyGen	30379171
Y945	Phosphorylation	score1	PhosphoSitePlus
T946	Phosphorylation	score1	PhosphoSitePlus
T970	Phosphorylation	score1	PhosphoSitePlus
K976	Ubiquitination	score1	PhosphoSitePlus
S977	Phosphorylation	score2	PhosphoSitePlus UniProt	18669648, 23186163, 21406692, ...20068231
S980	Phosphorylation	score1	PhosphoSitePlus
S984	Phosphorylation	score1	PhosphoSitePlus
Y986	Phosphorylation	score1	PhosphoSitePlus
K990	Methylation	score1	PhosphoSitePlus
S991	Phosphorylation	score1	PhosphoSitePlus
K992	Methylation	score1	PhosphoSitePlus
S993	Phosphorylation	score2	PhosphoSitePlus UniProt	21406692, 23186163
S1014	Phosphorylation	score1	PhosphoSitePlus
S1016	Phosphorylation	score2	PhosphoSitePlus UniProt	21406692

Site	PTM Type	Score	Source	PMID
S192	Phosphorylation	score0	HPRD	18669648, 19691289, 20068231
S220	Phosphorylation	score0	HPRD	18669648, 17081983, 20068231
S224	Phosphorylation	score0	HPRD	18669648, 17081983, 20068231
S226	Phosphorylation	score0	HPRD	18669648
S269	Phosphorylation	score0	HPRD	20068231
S289	Phosphorylation	score0	HPRD	18669648, 17081983, 20068231
S292	Phosphorylation	score0	HPRD	18669648, 17081983, 20068231
S294	Phosphorylation	score0	HPRD	18669648, 17081983, 20068231
T295	Phosphorylation	score0	HPRD	18669648, 17081983, 20068231
S326	Phosphorylation	score0	HPRD	19691289, 20068231
S360	Phosphorylation	score0	HPRD	17081983, 20068231
S362	Phosphorylation	score0	HPRD	18669648, 17081983, 20068231
S365	Phosphorylation	score0	HPRD	18669648, 17081983, 20068231
T542	Phosphorylation	score0	HPRD	19651622, 18669648
T602	Phosphorylation	score0	HPRD	20068231
S619	Phosphorylation	score0	HPRD	17081983, 19691289, 18452278, ...18669648, 19007248, 20068231
S625	Phosphorylation	score0	HPRD	20068231
S691	Phosphorylation	score0	HPRD	20068231
S796	Phosphorylation	score0	HPRD	20068231
T881	Phosphorylation	score0	HPRD	20068231
T889	Phosphorylation	score0	HPRD	19691289, 20068231
S891	Phosphorylation	score0	HPRD	18691976, 18669648, 19691289, ...20068231
T970	Phosphorylation	score0	HPRD	20068231
S977	Phosphorylation	score0	HPRD	19651622, 18669648, 19691289, ...20068231
S980	Phosphorylation	score0	HPRD	18669648, 19691289
T982	Phosphorylation	score0	HPRD	20068231
S991	Phosphorylation	score0	HPRD	19651622
S993	Phosphorylation	score0	HPRD	19651622, 18767875, 17081983, ...18212344

Site	PTM Type	Score	Source	PMID
S192	Phosphorylation	score2	HPRD PhosphoSitePlus	18669648, 19691289, 20068231
S220	Phosphorylation	score0	HPRD	18669648, 17081983, 20068231
S224	Phosphorylation	score0	HPRD	18669648, 17081983, 20068231
S226	Phosphorylation	score0	HPRD	18669648
S269	Phosphorylation	score0	HPRD	20068231
S289	Phosphorylation	score0	HPRD	18669648, 17081983, 20068231
S292	Phosphorylation	score0	HPRD	18669648, 17081983, 20068231
S294	Phosphorylation	score0	HPRD	18669648, 17081983, 20068231
T295	Phosphorylation	score0	HPRD	18669648, 17081983, 20068231
S326	Phosphorylation	score0	HPRD	19691289, 20068231
S360	Phosphorylation	score0	HPRD	17081983, 20068231
S362	Phosphorylation	score0	HPRD	18669648, 17081983, 20068231
S365	Phosphorylation	score0	HPRD	18669648, 17081983, 20068231
T542	Phosphorylation	score0	HPRD	19651622, 18669648
T602	Phosphorylation	score0	HPRD	20068231
S619	Phosphorylation	score0	HPRD	17081983, 19691289, 18452278, ...18669648, 19007248, 20068231
S625	Phosphorylation	score0	HPRD	20068231
S691	Phosphorylation	score0	HPRD	20068231
S796	Phosphorylation	score0	HPRD	20068231
T881	Phosphorylation	score0	HPRD	20068231
T889	Phosphorylation	score0	HPRD	19691289, 20068231
S891	Phosphorylation	score0	HPRD	18691976, 18669648, 19691289, ...20068231
T970	Phosphorylation	score0	HPRD	20068231
S977	Phosphorylation	score0	HPRD	19651622, 18669648, 19691289, ...20068231
S980	Phosphorylation	score0	HPRD	18669648, 19691289
T982	Phosphorylation	score0	HPRD	20068231
S991	Phosphorylation	score0	HPRD	19651622
S993	Phosphorylation	score0	HPRD	19651622, 18767875, 17081983, ...18212344
S1014	Phosphorylation	score1	PhosphoSitePlus
S1016	Phosphorylation	score1	PhosphoSitePlus
T1022	Phosphorylation	score1	PhosphoSitePlus

Site	PTM Type	Score	Source
K344	Ubiquitination	score1	PhosphoSitePlus
K352	Ubiquitination	score1	PhosphoSitePlus
K353	Ubiquitination	score1	PhosphoSitePlus
S976	Phosphorylation	score1	PhosphoSitePlus
S978	Phosphorylation	score1	PhosphoSitePlus
T984	Phosphorylation	score1	PhosphoSitePlus

PTM sites affected in variants

Site	Variant	Source	Disease [Sample source]
S179	T179	Biomuta	DOID:1793 / pancreatic cancer [ cosmic ] DOID:9253 / gastrointestinal stromal tumor [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
T210	S210	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
S218	N218	Biomuta	DOID:363 / uterine cancer [ icgc ]
S269	F269	Biomuta	DOID:4159 / skin cancer [ cosmic ]
S360	L360	Biomuta	DOID:4159 / skin cancer [ cosmic ]
T378	M378	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
T383	M383	Biomuta	DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ]
Y450	C450	Biomuta	DOID:1324 / lung cancer [ cosmic ]
S540	F540	Biomuta	DOID:4159 / skin cancer [ cosmic ]
S691	L691	Biomuta	DOID:4159 / skin cancer [ cosmic ]
S713	I713	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
S800	L800	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ]
S815	L815	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
T970	M970	Biomuta	DOID:10534 / stomach cancer [ cosmic ]
T982	M982	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc, cosmic, icgc ] DOID:4159 / skin cancer [ cosmic, cosmic, cosmic ] DOID:10534 / stomach cancer [ cosmic ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for Q6WCQ1 (MPRIP)

Protein Information

Interactive Sequence View

Q6WCQ1 (MPRIP) as Substrate

PTM sites affected in variants