iPTMnet Report for Q6VY07 (PACS1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q6VY07 / PACS1_HUMAN
Protein Name Phosphofurin acidic cluster sorting protein 1
Gene Name Name: PACS1
Synonyms:KIAA1175;
Organism Homo sapiens (Human)

PRO ID PR:Q6VY07
DAG View
PRO Name phosphofurin acidic cluster sorting protein 1 (human)
Definition A phosphofurin acidic cluster sorting protein 1 that is encoded in the genome of human.
Short Label hPACS1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q6VY07 (PACS1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330
R4 Methylation PhosphoSitePlus
S18 Phosphorylation PhosphoSitePlus
S28 Phosphorylation PhosphoSitePlus
T46 Phosphorylation phospho.ELM   PhosphoSitePlus 15302935
Y104 Phosphorylation PhosphoSitePlus
S112 Phosphorylation PhosphoSitePlus
S113 Phosphorylation PhosphoSitePlus
S114 Phosphorylation PhosphoSitePlus
S115 Phosphorylation PhosphoSitePlus
K132 Acetylation PhosphoSitePlus
K151 Acetylation PhosphoSitePlus
K249 Ubiquitination PhosphoSitePlus
Y251 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
S252 Phosphorylation PhosphoSitePlus
S255 Phosphorylation PhosphoSitePlus
K264 Ubiquitination PhosphoSitePlus
S278 Phosphorylation P68400 (CSNK2A1) phospho.ELM   PhosphoSitePlus   RLIMS-P 14633983
S292 Phosphorylation PhosphoSitePlus
Y303 Phosphorylation PhosphoSitePlus
K317 Ubiquitination PhosphoSitePlus
T319 Phosphorylation PhosphoSitePlus
S320 Phosphorylation PhosphoSitePlus
T321 Phosphorylation PhosphoSitePlus
S322 Phosphorylation PhosphoSitePlus
T325 Phosphorylation PhosphoSitePlus
K333 Ubiquitination PhosphoSitePlus
K339 Ubiquitination PhosphoSitePlus
S355 Phosphorylation PhosphoSitePlus
S379 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S381 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 24275569
T394 Phosphorylation PhosphoSitePlus
S407 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
S409 Phosphorylation PhosphoSitePlus
S410 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
S411 Phosphorylation PhosphoSitePlus
T413 Phosphorylation PhosphoSitePlus
S417 Phosphorylation PhosphoSitePlus
S423 Phosphorylation PhosphoSitePlus
K426 Acetylation PhosphoSitePlus
S430 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
K439 Ubiquitination PhosphoSitePlus
T443 O-Glycosylation GlyGen 33214551, 34725712, 34019948, ...29351928
T481 Phosphorylation PhosphoSitePlus
T488 Phosphorylation PhosphoSitePlus
S493 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S495 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S497 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T504 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S510 Phosphorylation PhosphoSitePlus
T511 Phosphorylation PhosphoSitePlus
S519 Phosphorylation PhosphoSitePlus   UniProt 23186163
S523 Phosphorylation PhosphoSitePlus
T526 Phosphorylation PhosphoSitePlus
S528 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S529 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S531 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692
S534 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S540 O-Glycosylation GlyGen 33214551, 34725712, 34019948, ...29351928
Y549 Phosphorylation PhosphoSitePlus
Y613 Phosphorylation PhosphoSitePlus
S651 Phosphorylation PhosphoSitePlus
Y672 Phosphorylation PhosphoSitePlus
Y680 Phosphorylation PhosphoSitePlus
S687 Phosphorylation PhosphoSitePlus
S770 Phosphorylation PhosphoSitePlus
S779 Phosphorylation PhosphoSitePlus
S789 Phosphorylation IEDB 35494241
S814 O-Glycosylation GlyGen 33214551, 34725712, 34019948, ...29351928
S844 Phosphorylation PhosphoSitePlus
S845 Phosphorylation PhosphoSitePlus
T848 Phosphorylation PhosphoSitePlus
K884 Acetylation PhosphoSitePlus
K903 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T46 Phosphorylation HPRD 19413330, 15302935
T124 Phosphorylation HPRD 20068231
Y251 Phosphorylation HPRD 18083107
S278 Phosphorylation P68400 (CSNK2A1) HPRD 16977309, 14633983
S379 Phosphorylation HPRD 18669648
S381 Phosphorylation HPRD 18669648
S407 Phosphorylation HPRD 17525332
S410 Phosphorylation HPRD 17525332
T429 Phosphorylation HPRD 18691976, 20068231
S430 Phosphorylation HPRD 18669648, 20068231
S493 Phosphorylation HPRD 18669648, 20068231
S495 Phosphorylation HPRD 18669648, 20068231
S497 Phosphorylation HPRD 18669648
T504 Phosphorylation HPRD 18669648, 20068231
T526 Phosphorylation HPRD 19651622
S528 Phosphorylation HPRD 19651622, 18669648
S529 Phosphorylation HPRD 19651622, 18669648, 20068231, ...20230923
S531 Phosphorylation HPRD 19651622, 18669648, 20068231, ...20230923
S534 Phosphorylation HPRD 19651622, 18669648, 20230923


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T46 M46 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T124 A124 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K249 N249 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S252 C252 Biomuta DOID:263 / kidney cancer [ cosmic ]
S322 F322 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:4362 / cervical cancer [ cosmic, icgc ]
T394 M394 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S407 L407 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S423 N423 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S423 R423 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K439 N439 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S497 R497 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T511 M511 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S531 C531 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S534 F534 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S540 N540 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S845 L845 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]