iPTMnet Report for Q6VMQ6 (ATF7IP)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q6VMQ6 / MCAF1_HUMAN
Protein Name Activating transcription factor 7-interacting protein 1
Gene Name Name: ATF7IP
Synonyms:MCAF,MCAF1;
Organism Homo sapiens (Human)

PRO ID PR:Q6VMQ6
DAG View
PRO Name activating transcription factor 7-interacting protein 1 (human)
Definition An activating transcription factor 7-interacting protein 1 that is encoded in the genome of human.
Short Label hATF7IP
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q6VMQ6 (ATF7IP) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378
S3 Phosphorylation PhosphoSitePlus
K33 Sumoylation PhosphoSitePlus
K33 Ubiquitination PhosphoSitePlus
S57 Phosphorylation PhosphoSitePlus   UniProt 23186163
S84 Phosphorylation PhosphoSitePlus
C93 Methylation IEDB 31844290
S113 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983, 24275569
T118 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S123 Phosphorylation PhosphoSitePlus
S293 Phosphorylation PhosphoSitePlus
K332 Acetylation PhosphoSitePlus
S334 Phosphorylation PhosphoSitePlus
T351 Phosphorylation PhosphoSitePlus
S403 Phosphorylation PhosphoSitePlus
S429 Phosphorylation PhosphoSitePlus
T432 Phosphorylation PhosphoSitePlus
S445 Phosphorylation PhosphoSitePlus   UniProt 23186163
C451 S-Nitrosylation dbSNO 26338901
S453 Phosphorylation PhosphoSitePlus
T463 Phosphorylation PhosphoSitePlus
S473 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S474 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S477 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 18669648
S479 Phosphorylation PhosphoSitePlus
S486 Phosphorylation PhosphoSitePlus
S496 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17081983, 24275569
S502 Phosphorylation PhosphoSitePlus
S512 Phosphorylation PhosphoSitePlus
S518 Phosphorylation PhosphoSitePlus
K548 Ubiquitination PhosphoSitePlus
S557 Phosphorylation PhosphoSitePlus
K558 Sumoylation PhosphoSitePlus
S559 Phosphorylation PhosphoSitePlus   UniProt 21406692, 24275569
K568 Ubiquitination PhosphoSitePlus
K588 Ubiquitination PhosphoSitePlus
K594 Ubiquitination PhosphoSitePlus
K597 Ubiquitination PhosphoSitePlus
K617 Ubiquitination PhosphoSitePlus
K623 Ubiquitination PhosphoSitePlus
K628 Ubiquitination PhosphoSitePlus
K636 Ubiquitination PhosphoSitePlus
K645 Ubiquitination PhosphoSitePlus
S673 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17081983, 24275569
T677 Phosphorylation PhosphoSitePlus
S701 Phosphorylation PhosphoSitePlus
K702 Sumoylation PhosphoSitePlus
S706 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...28314751, 35138101, 30379171, 32574038, 35254053, 34019948, 28657654, 30059200, 35132862, 30620550, 31492838, 32119511, 35289036, 29351928, 31373491, 29237092
S708 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...28314751, 35138101, 30379171, 32574038, 35254053, 34019948, 28657654, 30059200, 35132862, 30620550, 31492838, 32119511, 35289036, 29351928, 31373491, 29237092
S712 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...28314751, 35138101, 30379171, 32574038, 35254053, 34019948, 28657654, 30059200, 35132862, 30620550, 31492838, 32119511, 35289036, 29351928, 31373491, 29237092
T715 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...28314751, 35138101, 30379171, 32574038, 35254053, 34019948, 28657654, 30059200, 35132862, 30620550, 31492838, 32119511, 35289036, 29351928, 31373491, 29237092
T719 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...28314751, 35138101, 35254053, 30379171, 32574038, 32938750, 34019948, 28657654, 30059200, 35132862, 30620550, 31492838, 32119511, 35289036, 29351928, 31373491, 29237092
T723 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...28314751, 35138101, 30379171, 32574038, 35254053, 34019948, 28657654, 30059200, 35132862, 30620550, 31492838, 32119511, 35289036, 29351928, 31373491, 29237092
S733 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...28314751, 35138101, 30379171, 32574038, 35254053, 34019948, 28657654, 30059200, 35132862, 30620550, 31492838, 32119511, 35289036, 29351928, 31373491, 29237092
S734 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...28314751, 35138101, 34846842, 30379171, 32574038, 35254053, 34019948, 28657654, 30059200, 35132862, 30620550, 31492838, 32119511, 35289036, 29351928, 31373491, 29237092
S792 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...28314751, 35138101, 30379171, 32574038, 35254053, 34019948, 28657654, 30059200, 35132862, 30620550, 31492838, 32119511, 35289036, 29351928, 31373491, 29237092
S793 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...28314751, 35138101, 30379171, 32574038, 35254053, 34019948, 28657654, 30059200, 35132862, 30620550, 31492838, 32119511, 35289036, 29351928, 31373491, 29237092
S821 Phosphorylation PhosphoSitePlus
S834 O-Glycosylation GlyGen   IEDB 23301498, 27655845, 33214551, ...28314751, 35138101, 35254053, 30379171, 32574038, 32938750, 34019948, 28657654, 30059200, 35132862, 30620550, 31492838, 32119511, 35289036, 29351928, 31373491, 29237092
S834 Phosphorylation PhosphoSitePlus
S837 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...28314751, 35138101, 30379171, 32574038, 35254053, 34019948, 28657654, 30059200, 35132862, 30620550, 31492838, 32119511, 35289036, 29351928, 31373491, 29237092
T842 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...28314751, 35138101, 35254053, 30379171, 32574038, 32938750, 34019948, 28657654, 30059200, 35132862, 30620550, 31492838, 32119511, 35289036, 29351928, 31373491, 29237092
S849 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...28314751, 35138101, 34846842, 30379171, 32574038, 35254053, 34019948, 28657654, 30059200, 35132862, 30620550, 31492838, 32119511, 35289036, 29351928, 31373491, 29237092
S849 Phosphorylation phospho.ELM 18669648
S852 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S854 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...28314751, 35138101, 30379171, 32574038, 35254053, 34019948, 28657654, 30059200, 35132862, 30620550, 31492838, 32119511, 35289036, 29351928, 31373491, 29237092
S862 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...28314751, 35138101, 34846842, 30379171, 32574038, 35254053, 34019948, 28657654, 30059200, 35132862, 30620550, 31492838, 32119511, 35289036, 29351928, 31373491, 29237092
T869 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...28314751, 35138101, 30379171, 32574038, 35254053, 34019948, 28657654, 30059200, 35132862, 30620550, 31492838, 32119511, 35289036, 29351928, 31373491, 29237092
T877 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...28314751, 35138101, 30379171, 32574038, 35254053, 34019948, 28657654, 30059200, 35132862, 30620550, 31492838, 32119511, 35289036, 29351928, 31373491, 29237092
T885 O-Glycosylation GlyGen   IEDB 23301498, 27655845, 33214551, ...28314751, 35138101, 30379171, 32574038, 35254053, 34019948, 28657654, 30059200, 35132862, 30620550, 31492838, 32119511, 26280087, 35289036, 29351928, 31373491, 29237092
T887 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...28314751, 35138101, 30379171, 32574038, 35254053, 34019948, 28657654, 30059200, 35132862, 30620550, 31492838, 32119511, 35289036, 29351928, 31373491, 29237092
S888 O-Glycosylation GlyGen 34846842, 31373491
S895 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...28314751, 35138101, 30379171, 32574038, 35254053, 34019948, 28657654, 30059200, 35132862, 30620550, 31492838, 32119511, 35289036, 29351928, 31373491, 29237092
S899 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...28314751, 35138101, 30379171, 32574038, 35254053, 34019948, 28657654, 30059200, 35132862, 30620550, 31492838, 32119511, 35289036, 29351928, 31373491, 29237092
S899 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S914 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...28314751, 35138101, 35254053, 34846842, 30379171, 32574038, 32938750, 34019948, 28657654, 30059200, 35132862, 30620550, 31492838, 32119511, 35289036, 29351928, 31373491, 29237092
S917 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...28314751, 35138101, 34846842, 30379171, 32574038, 35254053, 34019948, 28657654, 30059200, 35132862, 30620550, 31492838, 32119511, 35289036, 29351928, 31373491, 29237092
T918 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...28314751, 35138101, 30379171, 32574038, 35254053, 34019948, 28657654, 30059200, 35132862, 30620550, 31492838, 32119511, 35289036, 29351928, 31373491, 29237092
T918 Phosphorylation PhosphoSitePlus
S919 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...28314751, 35138101, 30379171, 32574038, 35254053, 34019948, 28657654, 30059200, 35132862, 30620550, 31492838, 32119511, 35289036, 29351928, 31373491, 29237092
S920 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...28314751, 35138101, 30379171, 32574038, 35254053, 34019948, 28657654, 30059200, 35132862, 30620550, 31492838, 32119511, 35289036, 29351928, 31373491, 29237092
S926 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...28314751, 35138101, 30379171, 32574038, 35254053, 34019948, 28657654, 30059200, 35132862, 30620550, 31492838, 32119511, 35289036, 29351928, 31373491, 29237092
T928 Phosphorylation PhosphoSitePlus
T929 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...28314751, 35138101, 30379171, 32574038, 35254053, 34019948, 28657654, 30059200, 35132862, 30620550, 31492838, 32119511, 35289036, 29351928, 31373491, 29237092
T929 Phosphorylation PhosphoSitePlus
T936 Phosphorylation PhosphoSitePlus
K938 Acetylation PhosphoSitePlus
K938 Ubiquitination PhosphoSitePlus
S951 Phosphorylation PhosphoSitePlus
T970 Phosphorylation PhosphoSitePlus
S976 Phosphorylation PhosphoSitePlus
S979 Phosphorylation PhosphoSitePlus
T988 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...28314751, 35138101, 30379171, 32574038, 35254053, 34019948, 28657654, 30059200, 35132862, 30620550, 31492838, 32119511, 35289036, 29351928, 31373491, 29237092
S991 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...28314751, 35138101, 30379171, 32574038, 35254053, 34019948, 28657654, 30059200, 35132862, 30620550, 31492838, 32119511, 35289036, 29351928, 31373491, 29237092
T992 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...28314751, 35138101, 30379171, 32574038, 35254053, 34019948, 28657654, 30059200, 35132862, 30620550, 31492838, 32119511, 35289036, 29351928, 31373491, 29237092
S994 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...28314751, 35138101, 30379171, 32574038, 35254053, 34019948, 28657654, 30059200, 35132862, 30620550, 31492838, 32119511, 35289036, 29351928, 31373491, 29237092
S995 O-Glycosylation GlyGen 32574038
S996 Phosphorylation PhosphoSitePlus
T1066 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...28314751, 35138101, 35254053, 30379171, 32574038, 32938750, 34019948, 28657654, 30059200, 35132862, 30620550, 31492838, 32119511, 35289036, 29351928, 31373491, 29237092
R1087 Methylation PhosphoSitePlus
R1098 Methylation PhosphoSitePlus
C1190 Methylation IEDB 31844290
Site PTM Type PTM Enzyme Score Source PMID
T56 Phosphorylation HPRD 20068231
S57 Phosphorylation HPRD 20068231, 18452278
S113 Phosphorylation HPRD 19413330, 18669648, 17081983, ...18452278
T118 Phosphorylation HPRD 19413330, 18669648
S429 Phosphorylation HPRD 18452278
S445 Phosphorylation HPRD 19413330
S473 Phosphorylation HPRD 18669648, 20068231
S474 Phosphorylation HPRD 19651622, 18669648, 20068231, ...18452278
S477 Phosphorylation HPRD 19413330, 19664994, 18452278, ...19651622, 18669648, 20068231
S479 Phosphorylation HPRD 18452278
S496 Phosphorylation HPRD 19413330, 19651622, 19664994, ...17081983
S518 Phosphorylation HPRD 19413330
S559 Phosphorylation HPRD 19651622, 18452278
S673 Phosphorylation HPRD 19651622, 17081983, 20068231
S849 Phosphorylation HPRD 18669648
S852 Phosphorylation HPRD 18669648, 20068231
T887 Phosphorylation HPRD 20068231
Y898 Phosphorylation HPRD 20068231
S899 Phosphorylation HPRD 19413330, 18669648, 19664995
Site PTM Type PTM Enzyme Score Source PMID
S512 Phosphorylation PhosphoSitePlus
S518 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S474 F474 Biomuta DOID:4159 / skin cancer [ cosmic ]
S496 C496 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
S512 L512 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K558 T558 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K588 N588 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
K597 N597 Biomuta DOID:363 / uterine cancer [ icgc ]
S701 F701 Biomuta [ cosmic ]
S708 N708 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S821 N821 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S837 F837 Biomuta DOID:4159 / skin cancer [ cosmic ]
S849 F849 Biomuta DOID:4159 / skin cancer [ cosmic ]
S854 R854 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T877 I877 Biomuta DOID:4159 / skin cancer [ cosmic ]
S888 F888 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S919 L919 Biomuta [ cosmic ]
S919 * Biomuta DOID:10534 / stomach cancer [ cosmic ]
S920 C920 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S976 C976 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S979 A979 Biomuta DOID:4159 / skin cancer [ cosmic ]
S991 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S996 F996 Biomuta [ cosmic ] DOID:4159 / skin cancer [ cosmic, icgc ]
T1066 N1066 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
R1087 G1087 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
R1087 W1087 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
R1098 Q1098 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
R1098 * Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:4606 / bile duct cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]