iPTMnet Report for Q6UXX5 (ITIH6)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q6UXX5 / ITIH6_HUMAN
Protein Name Inter-alpha-trypsin inhibitor heavy chain H6 precursor
Gene Name Name: ITIH6
Synonyms:ITIH5L;ORFNames:UNQ6369/PRO21074;
Organism Homo sapiens (Human)

PRO ID PR:Q6UXX5
DAG View
PRO Name inter-alpha-trypsin inhibitor heavy chain H6 (human)
Definition An inter-alpha-trypsin inhibitor heavy chain H5-like protein that is encoded in the genome of human.
Short Label hITIH6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q6UXX5 (ITIH6) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S44 Phosphorylation PhosphoSitePlus
T45 Phosphorylation PhosphoSitePlus
S48 Phosphorylation PhosphoSitePlus
T456 Phosphorylation PhosphoSitePlus
K679 Acetylation PhosphoSitePlus
S770 Phosphorylation PhosphoSitePlus
S808 Phosphorylation PhosphoSitePlus
S1165 Phosphorylation PhosphoSitePlus
T1171 Phosphorylation PhosphoSitePlus
R1211 Methylation PhosphoSitePlus
R1215 Methylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T45 M45 Biomuta [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
S48 Y48 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K679 N679 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S770 L770 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ]
S808 * Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ]
S1165 C1165 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1165 Y1165 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1165 P1165 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
R1211 Q1211 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
R1211 * Biomuta DOID:363 / uterine cancer [ cosmic ]
R1215 M1215 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]