iPTMnet Report for Q6UXI9 (NPNT)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q6UXI9 / NPNT_HUMAN
Protein Name Nephronectin precursor
Gene Name Name: NPNT
Synonyms:EGFL6L,POEM;ORFNames:UNQ295/PRO334;
Organism Homo sapiens (Human)

PRO ID PR:Q6UXI9
DAG View
PRO Name nephronectin (human)
Definition A nephronectin that is encoded in the genome of human.
Short Label hNPNT
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q6UXI9 (NPNT) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K74 Ubiquitination PhosphoSitePlus
K96 Methylation PhosphoSitePlus
K96 Ubiquitination PhosphoSitePlus
Y205 Phosphorylation PhosphoSitePlus
Y223 Phosphorylation PhosphoSitePlus
S226 Phosphorylation PhosphoSitePlus
S227 Phosphorylation PhosphoSitePlus
K258 Ubiquitination PhosphoSitePlus
S264 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
N273 N-Glycosylation GlyGen 29741879
T327 O-Glycosylation GlyGen 30459171
S362 O-Glycosylation GlyGen 30459171
T363 O-Glycosylation GlyGen 30459171
T376 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
K380 Ubiquitination PhosphoSitePlus
S392 Phosphorylation PhosphoSitePlus
K459 Ubiquitination PhosphoSitePlus
K557 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K74 N74 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
K258 T258 Biomuta DOID:363 / uterine cancer [ icgc ]
K258 Q258 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S264 L264 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic, icgc ]
S362 T362 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]