iPTMnet Report for Q6UXD5 (SEZ6L2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q6UXD5 / SE6L2_HUMAN
Protein Name Seizure 6-like protein 2 precursor
Gene Name Name: SEZ6L2
Synonyms:PSK;ORFNames:UNQ1903/PRO4349;
Organism Homo sapiens (Human)

PRO ID PR:Q6UXD5
DAG View
PRO Name seizure 6-like protein 2 (human)
Definition A seizure 6-like protein 2 that is encoded in the genome of human.
Short Label hSEZ6L2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q6UXD5 (SEZ6L2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T43 O-Glycosylation GlyGen 30459171
T45 O-Glycosylation GlyGen 30459171
S48 O-Glycosylation GlyGen 30459171
T77 O-Glycosylation GlyGen 25813380
T80 O-Glycosylation GlyGen 30459171, 25813380
T86 O-Glycosylation GlyGen 30459171, 25813380
T96 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
T100 O-Glycosylation GlyGen   PhosphoSitePlus 25813380
T104 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
T105 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
T108 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
N247 N-Glycosylation GlyGen 23090970, 29391424, 24190977
N373 N-Glycosylation GlyGen 23090970, 29391424, 24190977
N641 N-Glycosylation GlyGen 23090970, 24190977
T666 O-Glycosylation GlyGen 25813380
T717 O-Glycosylation GlyGen 25813380
T831 O-Glycosylation GlyGen 25813380
T833 O-Glycosylation GlyGen 25813380
T834 O-Glycosylation GlyGen 25813380
K873 Ubiquitination PhosphoSitePlus
S879 Phosphorylation PhosphoSitePlus
S883 Phosphorylation PhosphoSitePlus
Y884 Phosphorylation PhosphoSitePlus
S885 Phosphorylation PhosphoSitePlus
Y898 Phosphorylation PhosphoSitePlus
T903 Phosphorylation PhosphoSitePlus
Y906 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T45 M45 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S48 T48 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
T77 M77 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
N641 K641 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S879 L879 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S883 F883 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y884 C884 Biomuta DOID:1324 / lung cancer [ icgc ]
T903 M903 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]