iPTMnet Report for Q6UVJ0 (SASS6)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q6UVJ0 / SAS6_HUMAN
Protein Name Spindle assembly abnormal protein 6 homolog
Gene Name Name: SASS6
Synonyms:SAS6;
Organism Homo sapiens (Human)

PRO ID PR:Q6UVJ0
DAG View
PRO Name spindle assembly abnormal protein 6 homolog (human)
Definition A spindle assembly abnormal protein 6 that is encoded in the genome of human.
Short Label hSASS6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q6UVJ0 (SASS6) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K17 Acetylation PhosphoSitePlus
Y58 Phosphorylation HPRD 20068231
S63 Phosphorylation HPRD 20068231
S69 Phosphorylation HPRD 20068231
T95 Phosphorylation PhosphoSitePlus
K100 Ubiquitination PhosphoSitePlus
K140 Ubiquitination PhosphoSitePlus
K158 Ubiquitination PhosphoSitePlus
K164 Ubiquitination PhosphoSitePlus
K209 Ubiquitination PhosphoSitePlus
K237 Ubiquitination PhosphoSitePlus
Y269 Phosphorylation PhosphoSitePlus
S273 Phosphorylation PhosphoSitePlus
T274 Phosphorylation PhosphoSitePlus
S304 Phosphorylation PhosphoSitePlus
T305 Phosphorylation PhosphoSitePlus
T347 O-Glycosylation GlyGen 23301498, 33214551, 30379171, ...32574038, 34019948, 30059200, 35132862, 31492838, 29485866, 35254053, 29237092
K486 Ubiquitination PhosphoSitePlus
S493 Phosphorylation HPRD   phospho.ELM 18669648, 20068231
T495 O-Glycosylation GlyGen 23301498, 33214551, 30379171, ...32574038, 34019948, 30059200, 35132862, 31492838, 29485866, 35254053, 29237092
T495 Phosphorylation PhosphoSitePlus
S500 O-Glycosylation GlyGen 23301498, 33214551, 30379171, ...32574038, 35254053, 34019948, 30059200, 35132862, 31492838, 29485866, 30620550, 29237092
S500 Phosphorylation PhosphoSitePlus
S502 O-Glycosylation GlyGen 23301498, 33214551, 30379171, ...32574038, 34019948, 30059200, 35132862, 31492838, 29485866, 35254053, 29237092
T504 O-Glycosylation GlyGen 23301498, 33214551, 30379171, ...32574038, 34019948, 30059200, 35132862, 31492838, 29485866, 35254053, 29237092
S507 Phosphorylation HPRD   PhosphoSitePlus 20068231
S510 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S533 O-Glycosylation GlyGen 23301498, 33214551, 30379171, ...32574038, 34019948, 30059200, 35132862, 31492838, 29485866, 35254053, 29237092
K548 Ubiquitination PhosphoSitePlus
S555 Phosphorylation HPRD   PhosphoSitePlus 20068231
K600 Ubiquitination PhosphoSitePlus
S608 Phosphorylation PhosphoSitePlus
S615 Phosphorylation PhosphoSitePlus   UniProt 23186163
S657 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q15468 (STIL) S1116 Q6UVJ0 (SASS6) increased_association eFIP 26101219
Phosphorylation Q8NHV4 (NEDD1) S325 Q6UVJ0 (SASS6) increased_association eFIP 33351100


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y58 N58 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
Y58 H58 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y269 H269 Biomuta DOID:3571 / liver cancer [ cosmic ]
K486 N486 Biomuta DOID:1612 / breast cancer [ cosmic ]
T495 P495 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S555 T555 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S615 I615 Biomuta DOID:4159 / skin cancer [ cosmic ]