iPTMnet Report for Q6UUV9 (CRTC1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q6UUV9 / CRTC1_HUMAN
Protein Name CREB-regulated transcription coactivator 1
Gene Name Name: CRTC1
Synonyms:KIAA0616;
Organism Homo sapiens (Human)

PRO ID PR:Q6UUV9
DAG View
PRO Name CREB-regulated transcription coactivator 1 (human)
Definition A CREB-regulated transcription coactivator 1 that is encoded in the genome of human.
Short Label hCRTC1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q6UUV9 (CRTC1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K13 Ubiquitination PhosphoSitePlus
K47 Ubiquitination PhosphoSitePlus
S48 Phosphorylation PhosphoSitePlus
Y50 Phosphorylation PhosphoSitePlus
S56 Phosphorylation PhosphoSitePlus
Y61 Phosphorylation phospho.ELM 18669648
S64 Phosphorylation PhosphoSitePlus
R103 Methylation PhosphoSitePlus
S113 Phosphorylation PhosphoSitePlus   UniProt 23186163
S120 Phosphorylation PhosphoSitePlus
K123 Acetylation PhosphoSitePlus
S130 Phosphorylation PhosphoSitePlus
S139 Phosphorylation PhosphoSitePlus
T149 Phosphorylation PhosphoSitePlus
S151 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 17525332, 16817901, 18669648, ...19244510, 26388727
S151 Phosphorylation P57059 (SIK1) neXtProt 19244510
S153 Phosphorylation PhosphoSitePlus
S158 Phosphorylation PhosphoSitePlus
T161 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S167 Phosphorylation Signor 16817901
S167 Phosphorylation P57059 (SIK1) Signor 16817901
S172 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
S215 Phosphorylation PhosphoSitePlus
S312 Phosphorylation PhosphoSitePlus
S330 Phosphorylation PhosphoSitePlus
S333 Phosphorylation PhosphoSitePlus
S424 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S153 Phosphorylation HPRD 17081983
Site PTM Type PTM Enzyme Score Source PMID
S64 Phosphorylation PhosphoSitePlus
S155 Phosphorylation PhosphoSitePlus
S167 Phosphorylation PhosphoSitePlus
S169 Phosphorylation HPRD 17081983
S188 Phosphorylation PhosphoSitePlus
S346 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S571 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S64 F64 Biomuta DOID:4159 / skin cancer [ cosmic, cosmic ]
R103 M103 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
R103 S103 Biomuta DOID:3571 / liver cancer [ cosmic ]
S113 P113 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S113 C113 Biomuta DOID:1324 / lung cancer [ cosmic ]
S113 F113 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ] DOID:263 / kidney cancer [ cosmic ]
S130 I130 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S167 F167 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S333 * Biomuta DOID:8618 / oral cavity cancer [ cosmic ]