iPTMnet Report for Q6UN15 (FIP1L1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q6UN15 / FIP1_HUMAN
Protein Name Pre-mRNA 3'-end -processing factor FIP1
Gene Name Name: FIP1L1
Synonyms:FIP1,RHE;
Organism Homo sapiens (Human)

PRO ID PR:Q6UN15
DAG View
PRO Name pre-mRNA 3'-end-processing factor FIP1 (human)
Definition A pre-mRNA 3'-end-processing factor FIP1 that is encoded in the genome of human.
Short Label hFIP1L1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q6UN15 (FIP1L1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S14 Phosphorylation PhosphoSitePlus
T17 Phosphorylation PhosphoSitePlus
Y27 Phosphorylation PhosphoSitePlus
S37 Phosphorylation PhosphoSitePlus
S57 Phosphorylation PhosphoSitePlus
S62 Phosphorylation PhosphoSitePlus
T79 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T81 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S85 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S87 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S89 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
Y110 Phosphorylation P12931 (SRC) phospho.ELM   PhosphoSitePlus 18698806, 16497976
S112 Phosphorylation PhosphoSitePlus
Y113 Phosphorylation phospho.ELM   PhosphoSitePlus 16497976
K123 Sumoylation PhosphoSitePlus
K123 Ubiquitination PhosphoSitePlus
Y129 Phosphorylation PhosphoSitePlus
K135 Ubiquitination PhosphoSitePlus
S146 Phosphorylation PhosphoSitePlus
K167 Ubiquitination PhosphoSitePlus
Y175 Phosphorylation PhosphoSitePlus
Y178 Phosphorylation PhosphoSitePlus
K186 Acetylation PhosphoSitePlus
T205 O-Glycosylation GlyGen 23301498, 34846842, 33214551, ...35138101, 34019948, 30379171, 32574038, 34065225, 28657654, 30059200, 35132862, 30620550, 29485866, 32119511, 35289036, 29351928, 31373491, 29237092, 20068230
S206 O-Glycosylation GlyGen 23301498, 34846842, 33214551, ...35138101, 34019948, 30379171, 32574038, 34065225, 28657654, 30059200, 35132862, 30620550, 31492838, 29485866, 32119511, 35289036, 29351928, 31373491, 29237092, 20068230
T207 O-Glycosylation GlyGen 23301498, 34846842, 33214551, ...35138101, 34019948, 30379171, 32574038, 34065225, 28657654, 30059200, 35132862, 30620550, 31492838, 29485866, 32119511, 35289036, 29351928, 31373491, 29237092, 20068230
T208 O-Glycosylation GlyGen 23301498, 34846842, 33214551, ...35138101, 34019948, 30379171, 32574038, 34065225, 28657654, 30059200, 35132862, 30620550, 29485866, 32119511, 35289036, 29351928, 31373491, 29237092, 20068230
T221 Phosphorylation PhosphoSitePlus
K235 Ubiquitination PhosphoSitePlus
T241 O-Glycosylation GlyGen 23301498, 34846842, 33214551, ...35138101, 34019948, 30379171, 32574038, 34065225, 30059200, 35132862, 30620550, 29485866, 32119511, 35289036, 29351928, 28657654, 29237092, 20068230
S244 O-Glycosylation GlyGen 32574038
S244 Phosphorylation PhosphoSitePlus
K246 Ubiquitination PhosphoSitePlus
T248 O-Glycosylation GlyGen 23301498, 34846842, 33214551, ...35138101, 34019948, 30379171, 32574038, 34065225, 30059200, 35132862, 30620550, 29485866, 32119511, 35289036, 29351928, 28657654, 29237092, 20068230
S252 O-Glycosylation GlyGen 23301498, 34846842, 33214551, ...35138101, 34019948, 30379171, 32574038, 34065225, 30059200, 35132862, 30620550, 29485866, 32119511, 35289036, 29351928, 28657654, 29237092, 20068230
T253 O-Glycosylation GlyGen   PhosphoSitePlus 23301498, 34846842, 33214551, ...35138101, 34019948, 30379171, 32574038, 34065225, 30059200, 35132862, 30620550, 31492838, 29485866, 32119511, 35289036, 29351928, 28657654, 29237092, 20068230
K254 Sumoylation PhosphoSitePlus
K254 Ubiquitination PhosphoSitePlus
T258 O-Glycosylation GlyGen 23301498, 34846842, 33214551, ...35138101, 34019948, 30379171, 32574038, 34065225, 30059200, 35132862, 30620550, 29485866, 32119511, 35289036, 29351928, 28657654, 29237092, 20068230
T258 Phosphorylation PhosphoSitePlus
S259 O-Glycosylation GlyGen 23301498, 34846842, 33214551, ...35138101, 34019948, 30379171, 32574038, 34065225, 30059200, 35132862, 30620550, 29485866, 32119511, 35289036, 29351928, 28657654, 29237092, 20068230
S259 Phosphorylation IEDB   phospho.ELM   PhosphoSitePlus 27920218, 18669648, 15302935, ...16964243
S262 Phosphorylation PhosphoSitePlus
K265 Methylation PhosphoSitePlus
S274 Phosphorylation PhosphoSitePlus
T275 O-Glycosylation GlyGen   PhosphoSitePlus 23301498, 34846842, 33214551, ...35138101, 34019948, 30379171, 32574038, 34065225, 30059200, 35132862, 30620550, 29485866, 32119511, 35289036, 29351928, 28657654, 29237092, 20068230
S276 O-Glycosylation GlyGen   PhosphoSitePlus 23301498, 33214551, 35138101, ...34019948, 34846842, 30379171, 32574038, 34065225, 30059200, 35132862, 30620550, 29485866, 32119511, 35289036, 29351928, 28657654, 29237092, 20068230
S277 Phosphorylation PhosphoSitePlus
S279 Phosphorylation PhosphoSitePlus
T281 Phosphorylation PhosphoSitePlus
T283 Phosphorylation PhosphoSitePlus
K294 Acetylation PhosphoSitePlus
K294 Ubiquitination PhosphoSitePlus
S304 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 17081983
S345 O-Glycosylation GlyGen 23301498, 34846842, 33214551, ...35138101, 34019948, 30379171, 32574038, 34065225, 30059200, 35132862, 30620550, 29485866, 32119511, 35289036, 29351928, 28657654, 29237092, 20068230
T347 O-Glycosylation GlyGen 23301498, 34846842, 33214551, ...35138101, 34019948, 30379171, 32574038, 34065225, 30059200, 35132862, 30620550, 29485866, 32119511, 35289036, 29351928, 28657654, 29237092, 20068230
T367 O-Glycosylation GlyGen 23301498, 34846842, 33214551, ...35138101, 34019948, 30379171, 32574038, 34065225, 30059200, 35132862, 30620550, 29485866, 32119511, 35289036, 29351928, 28657654, 29237092, 20068230
S382 O-Glycosylation GlyGen 23301498, 34846842, 33214551, ...35138101, 34019948, 30379171, 32574038, 34065225, 30059200, 35132862, 30620550, 29485866, 32119511, 35289036, 29351928, 28657654, 29237092, 20068230
S403 O-Glycosylation GlyGen 23301498, 34846842, 33214551, ...35138101, 34019948, 30379171, 32574038, 34065225, 30059200, 35132862, 30620550, 29485866, 32119511, 35289036, 29351928, 28657654, 29237092, 20068230
Y426 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15592455
S440 Phosphorylation PhosphoSitePlus
S443 Phosphorylation PhosphoSitePlus
Y453 Phosphorylation PhosphoSitePlus
Y454 Phosphorylation PhosphoSitePlus
T482 Phosphorylation PhosphoSitePlus
S492 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 18220336, ...18669648, 19690332, 20068231
T494 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332, 18220336
S496 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 19690332
S500 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 18669648, ...24275569, 19690332
Y505 Phosphorylation PhosphoSitePlus
Y510 Phosphorylation PhosphoSitePlus
R513 Methylation PhosphoSitePlus
Y515 Phosphorylation PhosphoSitePlus
S521 Phosphorylation PhosphoSitePlus
S548 Phosphorylation PhosphoSitePlus
S554 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17081983, 20068231, 24275569, ...18318008
S559 Phosphorylation PhosphoSitePlus
S571 Phosphorylation PhosphoSitePlus
S579 Phosphorylation PhosphoSitePlus
T591 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S14 Phosphorylation HPRD 18452278
T79 Phosphorylation HPRD 18691976, 18669648, 17081983
T81 Phosphorylation HPRD 18669648, 17081983
S85 Phosphorylation HPRD 18691976, 18669648, 17081983, ...18452278
S87 Phosphorylation HPRD 18691976, 18669648, 17081983, ...18452278
S89 Phosphorylation HPRD 19651622, 18691976, 18669648, ...17081983, 18452278
T99 Phosphorylation HPRD 17081983
S259 Phosphorylation HPRD 19413330, 18691976, 16964243, ...20058876, 19664994, 19664995, 19651622, 18669648, 20068231
S262 Phosphorylation HPRD 19651622, 20068231
Y299 Phosphorylation HPRD 20068231
S304 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231
T482 Phosphorylation HPRD 20068231
S492 Phosphorylation HPRD 19413330, 18691976, 18767875, ...19664994, 19664995, 18452278, 17322306, 18669648, 19651622, 18707149, 19415658, 20068231
T494 Phosphorylation HPRD 18767875, 19664995, 18452278, ...17322306, 18669648, 20068231
S496 Phosphorylation HPRD 17322306, 18767875, 19664995, ...18452278, 19651622, 18669648, 20068231
S500 Phosphorylation HPRD 19413330, 17081983, 19664994, ...18452278, 19651622, 18669648, 19415658
Y505 Phosphorylation HPRD 17081983
S548 Phosphorylation HPRD 17081983
S554 Phosphorylation HPRD 19651622, 18212344, 17081983, ...20068231, 18452278
S559 Phosphorylation HPRD 17081983
S579 Phosphorylation HPRD 19413330
S587 Phosphorylation HPRD 20068231
T588 Phosphorylation HPRD 19651622
Site PTM Type PTM Enzyme Score Source PMID
K195 Ubiquitination PhosphoSitePlus
S221 Phosphorylation PhosphoSitePlus
S224 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S37 G37 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y113 C113 Biomuta DOID:3571 / liver cancer [ cosmic ]
Y175 N175 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K195 E195 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T207 S207 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T208 A208 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S221 Y221 Biomuta DOID:1319 / brain cancer [ icgc ]
S221 F221 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S224 P224 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S244 L244 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S252 F252 Biomuta DOID:4159 / skin cancer [ cosmic ]
K254 Q254 Biomuta DOID:1793 / pancreatic cancer [ icgc ]
T258 N258 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S259 Y259 Biomuta DOID:1319 / brain cancer [ icgc ]
S259 F259 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S262 P262 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
K265 T265 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K265 N265 Biomuta DOID:1324 / lung cancer [ icgc ]
S277 F277 Biomuta DOID:4159 / skin cancer [ cosmic ]
S279 C279 Biomuta DOID:1612 / breast cancer [ cosmic ]
S279 F279 Biomuta DOID:363 / uterine cancer [ icgc ]
T281 R281 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S403 C403 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S440 L440 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S492 I492 Biomuta DOID:1793 / pancreatic cancer [ icgc ]
Y515 * Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S559 I559 Biomuta DOID:10534 / stomach cancer [ cosmic ]