iPTMnet Report for Q6UB35 (MTHFD1L)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q6UB35 / C1TM_HUMAN
Protein Name Monofunctional C1-tetrahydrofolate synthase, mitochondrial precursor
Gene Name Name: MTHFD1L
Synonyms:FTHFSDC1;
Organism Homo sapiens (Human)

PRO ID PR:Q6UB35
DAG View
PRO Name monofunctional C1-tetrahydrofolate synthase, mitochondrial (human)
Definition A monofunctional C1-tetrahydrofolate synthase, mitochondrial that is encoded in the genome of human.
Short Label hMTHFD1L
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q6UB35 (MTHFD1L) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S59 Phosphorylation PhosphoSitePlus
K168 Acetylation PhosphoSitePlus
K174 Acetylation PhosphoSitePlus
K189 Acetylation PhosphoSitePlus   UniProt 19608861
K189 Ubiquitination PhosphoSitePlus
C198 Methylation IEDB 31844290
S271 Phosphorylation PhosphoSitePlus
K352 Acetylation PhosphoSitePlus
S357 Phosphorylation P24941 (CDK2) PhosphoSitePlus   UniProt 18847512, 23186163
Y391 Phosphorylation PhosphoSitePlus
K393 Ubiquitination PhosphoSitePlus
K516 Acetylation PhosphoSitePlus
K516 Ubiquitination PhosphoSitePlus
T554 Phosphorylation PhosphoSitePlus
K560 Ubiquitination PhosphoSitePlus
T579 Phosphorylation PhosphoSitePlus
R582 Methylation PhosphoSitePlus
K586 Ubiquitination PhosphoSitePlus
T588 O-Glycosylation GlyGen 23301498, 30379171, 34725712, ...35083852
T594 Phosphorylation PhosphoSitePlus
K596 Acetylation PhosphoSitePlus
S636 O-Glycosylation GlyGen 23301498, 30379171, 34725712, ...35083852
K727 Ubiquitination PhosphoSitePlus
R819 Methylation PhosphoSitePlus
Y859 Phosphorylation PhosphoSitePlus
S885 Phosphorylation PhosphoSitePlus
K891 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T594 Phosphorylation HPRD 19664995
S885 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S59 N59 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S357 C357 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
R819 Q819 Biomuta DOID:10534 / stomach cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ]
S885 C885 Biomuta DOID:3571 / liver cancer [ cosmic ]