Protein Information

Cytoscape View


UniProt AC / UniProt ID Q6U841 / S4A10_HUMAN
Protein Name Sodium-driven chloride bicarbonate exchanger
Gene Name Name: SLC4A10
Synonyms:NBCN2;
Organism Homo sapiens (Human)

PRO ID PR:Q6U841
DAG View
PRO Name sodium-driven chloride bicarbonate exchanger (human)
Definition A sodium-driven chloride bicarbonate exchanger that is encoded in the genome of human.
Short Label hSLC4A10
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q6U841 (SLC4A10) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S89 Phosphorylation PhosphoSitePlus
S91 Phosphorylation PhosphoSitePlus
Y158 Phosphorylation PhosphoSitePlus
T161 Phosphorylation PhosphoSitePlus
S238 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S247 Phosphorylation PhosphoSitePlus
S276 Phosphorylation PhosphoSitePlus
S280 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T281 Phosphorylation PhosphoSitePlus
S353 Phosphorylation PhosphoSitePlus
T368 Phosphorylation PhosphoSitePlus
N677 N-Glycosylation GlyGen   UniProt 18061361
N687 N-Glycosylation GlyGen   UniProt 18061361
N697 N-Glycosylation GlyGen   UniProt 18061361
K755 Ubiquitination PhosphoSitePlus
S948 Phosphorylation PhosphoSitePlus
S949 Phosphorylation PhosphoSitePlus
K1043 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S89 Phosphorylation HPRD 18510355
S238 Phosphorylation HPRD 18767875, 18669648
S280 Phosphorylation HPRD 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S91 F91 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
Y158 H158 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
T368 N368 Biomuta DOID:1324 / lung cancer [ tcga ]
T368 A368 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
N697 T697 Biomuta DOID:5041 / esophageal cancer [ icgc ]
S948 L948 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
S949 Y949 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]