iPTMnet Report for Q6S5L8 (SHC4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q6S5L8 / SHC4_HUMAN
Protein Name SHC-transforming protein 4
Gene Name Name: SHC4
Synonyms:SHCD;ORFNames:UNQ6438/PRO21364;
Organism Homo sapiens (Human)

PRO ID PR:Q6S5L8
DAG View
PRO Name SHC-transforming protein 4 (human)
Definition An SHC-transforming protein 4 that is encoded in the genome of human.
Short Label hSHC4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q6S5L8 (SHC4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S8 Phosphorylation PhosphoSitePlus
Y15 Phosphorylation PhosphoSitePlus
S132 Phosphorylation PhosphoSitePlus
T159 Phosphorylation PhosphoSitePlus
Y374 Phosphorylation PhosphoSitePlus
Y375 Phosphorylation PhosphoSitePlus
Y403 Phosphorylation PhosphoSitePlus
Y413 Phosphorylation PhosphoSitePlus
Y424 Phosphorylation PhosphoSitePlus   UniProt 17452444
T448 Phosphorylation PhosphoSitePlus
S449 Phosphorylation PhosphoSitePlus
Y465 Phosphorylation PhosphoSitePlus
S473 Phosphorylation PhosphoSitePlus
K534 Acetylation PhosphoSitePlus
S538 Phosphorylation PhosphoSitePlus
K542 Acetylation PhosphoSitePlus
K569 Acetylation PhosphoSitePlus
Y596 Phosphorylation PhosphoSitePlus
S601 Phosphorylation PhosphoSitePlus
S606 Phosphorylation PhosphoSitePlus
S609 Phosphorylation PhosphoSitePlus
S612 Phosphorylation PhosphoSitePlus
S628 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y15 H15 Biomuta DOID:3571 / liver cancer [ cosmic ]
Y375 H375 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y465 * Biomuta DOID:4159 / skin cancer [ cosmic ]
S609 I609 Biomuta DOID:1324 / lung cancer [ cosmic ]
S628 F628 Biomuta DOID:4159 / skin cancer [ cosmic ]