iPTMnet Report for Q6RFH5 (WDR74)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q6RFH5 / WDR74_HUMAN
Protein Name WD repeat-containing protein 74
Gene Name Name: WDR74
Synonyms:NSA1;
Organism Homo sapiens (Human)

PRO ID PR:Q6RFH5
DAG View
PRO Name WD repeat-containing protein 74 (human)
Definition A WD repeat-containing protein 74 that is encoded in the genome of human.
Short Label hWDR74
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q6RFH5 (WDR74) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K21 Sumoylation PhosphoSitePlus
K21 Ubiquitination PhosphoSitePlus
K28 Ubiquitination PhosphoSitePlus
T52 Phosphorylation PhosphoSitePlus
K68 Ubiquitination PhosphoSitePlus
S71 Phosphorylation PhosphoSitePlus
K115 Ubiquitination PhosphoSitePlus
K117 Ubiquitination PhosphoSitePlus
K151 Ubiquitination PhosphoSitePlus
K156 Sumoylation PhosphoSitePlus
K156 Ubiquitination PhosphoSitePlus
K197 Ubiquitination PhosphoSitePlus
Y204 Phosphorylation PhosphoSitePlus
S214 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
K266 Ubiquitination PhosphoSitePlus
K281 Ubiquitination PhosphoSitePlus
K307 Ubiquitination PhosphoSitePlus
K311 Methylation PhosphoSitePlus   UniProt 24129315
K311 Ubiquitination PhosphoSitePlus
S312 Phosphorylation PhosphoSitePlus
S320 Phosphorylation PhosphoSitePlus
K337 Sumoylation PhosphoSitePlus
K337 Ubiquitination PhosphoSitePlus
T345 O-Glycosylation PhosphoSitePlus
S351 O-Glycosylation PhosphoSitePlus
K357 Ubiquitination PhosphoSitePlus
K359 Sumoylation PhosphoSitePlus
K359 Ubiquitination PhosphoSitePlus
S361 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231, ...24275569
S382 Phosphorylation PhosphoSitePlus
T383 Phosphorylation PhosphoSitePlus
S384 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S214 Phosphorylation HPRD 20068231
S361 Phosphorylation HPRD 18669648, 19691289, 20068231
S382 Phosphorylation HPRD 19651622, 17081983
S384 Phosphorylation HPRD 19651622, 17081983, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S71 T71 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
K117 N117 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K117 * Biomuta DOID:1612 / breast cancer [ cosmic ]
S312 Y312 Biomuta DOID:363 / uterine cancer [ icgc ]
T345 A345 Biomuta DOID:10534 / stomach cancer [ cosmic ]