iPTMnet Report for Q6R327 (RICTOR)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q6R327 / RICTR_HUMAN
Protein Name Rapamycin-insensitive companion of mTOR
Gene Name Name: RICTOR
Synonyms:KIAA1999;
Organism Homo sapiens (Human)

PRO ID PR:Q6R327
DAG View
PRO Name rapamycin-insensitive companion of mTOR (human)
Definition A rapamycin-insensitive companion of mTOR that is encoded in the genome of human.
Short Label hRICTOR
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q6R327 (RICTOR) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R6 Methylation PhosphoSitePlus
S21 Phosphorylation PhosphoSitePlus   UniProt 18691976, 21406692, 23186163, ...17081983, 18220336, 18669648, 19690332, 20068231
S35 Phosphorylation PhosphoSitePlus
K56 Ubiquitination PhosphoSitePlus
K65 Ubiquitination PhosphoSitePlus
K97 Ubiquitination PhosphoSitePlus
Y109 Phosphorylation PhosphoSitePlus
K213 Acetylation PhosphoSitePlus
Y243 Phosphorylation PhosphoSitePlus
S265 Phosphorylation PhosphoSitePlus
K274 Ubiquitination PhosphoSitePlus   UniProt 33378666
S284 Phosphorylation PhosphoSitePlus
K374 Ubiquitination PhosphoSitePlus
S383 Phosphorylation PhosphoSitePlus
T424 Phosphorylation PhosphoSitePlus
K477 Ubiquitination PhosphoSitePlus
T504 Phosphorylation IEDB 35494241
K507 Ubiquitination PhosphoSitePlus
K516 Ubiquitination PhosphoSitePlus
K522 Ubiquitination PhosphoSitePlus
K566 Ubiquitination PhosphoSitePlus
K582 Acetylation PhosphoSitePlus
K719 Ubiquitination PhosphoSitePlus
T733 Phosphorylation PhosphoSitePlus
K764 Ubiquitination PhosphoSitePlus
K781 Ubiquitination PhosphoSitePlus
K791 Ubiquitination PhosphoSitePlus
K813 Ubiquitination PhosphoSitePlus
Y823 Phosphorylation PhosphoSitePlus
K826 Ubiquitination PhosphoSitePlus
K830 Ubiquitination PhosphoSitePlus
Y835 Phosphorylation PhosphoSitePlus
S837 Phosphorylation PhosphoSitePlus
T853 O-Glycosylation GlyGen 29237092
K856 Ubiquitination PhosphoSitePlus
Y863 Phosphorylation PhosphoSitePlus
K916 Ubiquitination PhosphoSitePlus
K921 Ubiquitination PhosphoSitePlus
K979 Ubiquitination PhosphoSitePlus
K986 Methylation PhosphoSitePlus
K986 Ubiquitination PhosphoSitePlus
S1026 Phosphorylation PhosphoSitePlus
S1028 Phosphorylation PhosphoSitePlus
S1030 Phosphorylation PhosphoSitePlus
S1031 Phosphorylation PhosphoSitePlus
S1035 Phosphorylation PhosphoSitePlus
S1037 Phosphorylation PhosphoSitePlus
Y1073 Phosphorylation PhosphoSitePlus
K1082 Ubiquitination PhosphoSitePlus
S1084 Phosphorylation PhosphoSitePlus
S1090 Phosphorylation PhosphoSitePlus
K1092 Ubiquitination PhosphoSitePlus
S1101 Phosphorylation PhosphoSitePlus
T1103 Phosphorylation PhosphoSitePlus   UniProt 23186163
K1107 Ubiquitination PhosphoSitePlus
K1116 Acetylation PhosphoSitePlus
K1119 Acetylation PhosphoSitePlus
S1121 O-Glycosylation GlyGen 30379171, 28510447, 30059200
K1125 Acetylation PhosphoSitePlus
K1125 Ubiquitination PhosphoSitePlus
T1133 Phosphorylation PhosphoSitePlus
T1135 Phosphorylation Q9UBS0 (RPS6KB2) , P31749 (AKT1) , P23443 (RPS6KB1) , O00141 (SGK1) neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 23186163, 26356562, 21204013, ...22310280, 19995915, 28287249, 25738366, 27239959, 20832730, 19935711, 19720745
S1138 Phosphorylation PhosphoSitePlus
S1144 Phosphorylation PhosphoSitePlus
T1148 Phosphorylation PhosphoSitePlus
T1161 Phosphorylation PhosphoSitePlus
S1162 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 25714006, 23186163
K1167 Ubiquitination PhosphoSitePlus
T1172 Phosphorylation PhosphoSitePlus
S1174 Phosphorylation PhosphoSitePlus
T1175 Phosphorylation PhosphoSitePlus
S1177 Phosphorylation PhosphoSitePlus
K1184 Ubiquitination PhosphoSitePlus
K1187 Ubiquitination PhosphoSitePlus
S1211 Phosphorylation PhosphoSitePlus
S1217 Phosphorylation PhosphoSitePlus
S1219 Phosphorylation PhosphoSitePlus
T1222 Phosphorylation PhosphoSitePlus
T1224 Phosphorylation PhosphoSitePlus
T1225 Phosphorylation PhosphoSitePlus
T1226 Phosphorylation PhosphoSitePlus
S1227 Phosphorylation PhosphoSitePlus
S1230 Phosphorylation PhosphoSitePlus
S1231 Phosphorylation PhosphoSitePlus
S1234 Phosphorylation PhosphoSitePlus
S1235 Phosphorylation P49841 (GSK3B) PhosphoSitePlus 21343617
K1265 Ubiquitination PhosphoSitePlus
S1267 Phosphorylation PhosphoSitePlus
Y1269 Phosphorylation PhosphoSitePlus
T1271 Phosphorylation PhosphoSitePlus
S1274 Phosphorylation PhosphoSitePlus
S1278 Phosphorylation PhosphoSitePlus   UniProt 23186163
K1281 Ubiquitination PhosphoSitePlus
S1282 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163
S1284 Phosphorylation PhosphoSitePlus   UniProt 19690332
S1286 Phosphorylation PhosphoSitePlus
S1292 Phosphorylation PhosphoSitePlus
S1293 Phosphorylation PhosphoSitePlus
T1295 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1302 Phosphorylation PhosphoSitePlus   UniProt 23186163
K1304 Methylation PhosphoSitePlus
K1304 Ubiquitination PhosphoSitePlus
S1307 Phosphorylation PhosphoSitePlus
T1310 Phosphorylation PhosphoSitePlus
K1312 Acetylation PhosphoSitePlus
K1312 Methylation PhosphoSitePlus
K1312 Ubiquitination PhosphoSitePlus
S1313 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1320 Phosphorylation PhosphoSitePlus
Y1321 Phosphorylation PhosphoSitePlus
S1324 Phosphorylation IEDB 32357974
Y1330 Phosphorylation PhosphoSitePlus
T1332 Phosphorylation PhosphoSitePlus   UniProt 23186163
K1334 Methylation PhosphoSitePlus
K1334 Ubiquitination PhosphoSitePlus
S1344 Phosphorylation PhosphoSitePlus
S1346 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1348 O-Glycosylation GlyGen 30379171, 28510447, 30059200
S1348 Phosphorylation PhosphoSitePlus
S1353 Phosphorylation PhosphoSitePlus   UniProt 23186163
T1361 Phosphorylation PhosphoSitePlus
K1367 Methylation PhosphoSitePlus
S1370 Phosphorylation PhosphoSitePlus
S1373 Phosphorylation PhosphoSitePlus
T1376 Phosphorylation PhosphoSitePlus
K1382 Ubiquitination PhosphoSitePlus
S1385 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
Y1386 Phosphorylation PhosphoSitePlus
S1388 Phosphorylation PhosphoSitePlus   UniProt 18669648, 19690332
K1391 Ubiquitination PhosphoSitePlus
S1396 Phosphorylation PhosphoSitePlus   UniProt 18691976, 18669648
T1402 Phosphorylation PhosphoSitePlus
S1406 Phosphorylation PhosphoSitePlus
S1407 Phosphorylation PhosphoSitePlus
S1411 Phosphorylation PhosphoSitePlus   UniProt 19690332
S1414 Phosphorylation PhosphoSitePlus
S1415 Phosphorylation PhosphoSitePlus
T1417 Phosphorylation PhosphoSitePlus
Y1418 Phosphorylation PhosphoSitePlus
S1421 Phosphorylation PhosphoSitePlus
K1440 Acetylation IEDB 34357683
Y1444 Phosphorylation PhosphoSitePlus
T1447 Phosphorylation PhosphoSitePlus
K1448 Ubiquitination PhosphoSitePlus
S1470 Phosphorylation PhosphoSitePlus
T1472 Phosphorylation PhosphoSitePlus
K1477 Ubiquitination PhosphoSitePlus
S1479 Phosphorylation PhosphoSitePlus
S1571 Phosphorylation PhosphoSitePlus
S1574 Phosphorylation PhosphoSitePlus
S1577 Phosphorylation PhosphoSitePlus
S1581 Phosphorylation PhosphoSitePlus
S1585 Phosphorylation PhosphoSitePlus
K1590 Ubiquitination PhosphoSitePlus
S1591 Phosphorylation PhosphoSitePlus   UniProt 21406692
T1592 Phosphorylation PhosphoSitePlus
K1599 Ubiquitination PhosphoSitePlus
T1605 Phosphorylation PhosphoSitePlus
K1640 Ubiquitination PhosphoSitePlus
T1695 Phosphorylation P49841 (GSK3B) , P49840 (GSK3A) PhosphoSitePlus   UniProt 25897075
Site PTM Type PTM Enzyme Score Source PMID
S21 Phosphorylation HPRD 18691976, 15302935, 19664994, ...19691289, 18452278, 19651622, 18669648, 20068231
Y262 Phosphorylation HPRD 18669648
S1219 Phosphorylation HPRD 18669648
T1222 Phosphorylation HPRD 18669648
S1235 Phosphorylation HPRD 19691289
S1282 Phosphorylation HPRD 18669648
S1284 Phosphorylation HPRD 18767875, 18669648
T1295 Phosphorylation HPRD 18212344
S1344 Phosphorylation HPRD 18669648
S1348 Phosphorylation HPRD 18669648
S1353 Phosphorylation HPRD 18691976
S1385 Phosphorylation HPRD 18669648
Y1386 Phosphorylation HPRD 19413330, 18669648
S1388 Phosphorylation HPRD 19413330, 18669648
S1396 Phosphorylation HPRD 18691976, 18669648
S1591 Phosphorylation HPRD 19651622, 20068231
T1592 Phosphorylation HPRD 19651622
Site PTM Type PTM Enzyme Score Source PMID
S1378 Phosphorylation PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q6R327 (RICTOR) T1135 Q13616 (CUL1) inhibited_association eFIP 20832730
Phosphorylation Q6R327 (RICTOR) T1135 P42345 (MTOR) inhibited_association eFIP 27239959
Phosphorylation Q6R327 (RICTOR) T1135 Q3U182 (Crtc2) unknown eFIP 32642408
Phosphorylation Q6R327 (RICTOR) T1135 Q13616 (CUL1) inhibited_association eFIP 21204013


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K56 N56 Biomuta DOID:1324 / lung cancer [ cosmic ]
K65 N65 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K65 M65 Biomuta [ cosmic ]
K374 T374 Biomuta DOID:3571 / liver cancer [ cosmic ]
T504 R504 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K566 E566 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K582 E582 Biomuta DOID:3571 / liver cancer [ cosmic ]
K830 N830 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S837 F837 Biomuta DOID:2531 / hematologic cancer [ cosmic, icgc ]
K916 E916 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K921 I921 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1031 C1031 Biomuta DOID:3571 / liver cancer [ cosmic ]
S1084 L1084 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1101 L1101 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ] DOID:11615 / penile cancer [ cosmic ] DOID:1319 / brain cancer [ icgc ]
T1103 I1103 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T1135 M1135 Biomuta [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
T1135 A1135 Biomuta DOID:4159 / skin cancer [ cosmic ]
K1167 E1167 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T1172 A1172 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K1184 T1184 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K1184 Q1184 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
K1187 N1187 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic ]
S1211 L1211 Biomuta DOID:4159 / skin cancer [ cosmic ]
T1222 I1222 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:1612 / breast cancer [ cosmic, icgc ]
S1235 R1235 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1274 C1274 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1278 F1278 Biomuta DOID:1319 / brain cancer [ cosmic ]
S1282 * Biomuta DOID:4159 / skin cancer [ cosmic ]
S1284 L1284 Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
S1307 P1307 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y1330 C1330 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
T1332 A1332 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S1346 C1346 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1348 C1348 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S1353 Y1353 Biomuta DOID:363 / uterine cancer [ icgc ]
S1373 F1373 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
T1376 A1376 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1378 N1378 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K1382 Q1382 Biomuta DOID:1793 / pancreatic cancer [ icgc ]
T1402 P1402 Biomuta DOID:1612 / breast cancer [ cosmic ]
S1406 F1406 Biomuta DOID:263 / kidney cancer [ cosmic ]
S1406 Y1406 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S1407 F1407 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S1421 L1421 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S1421 P1421 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
T1447 I1447 Biomuta DOID:4159 / skin cancer [ cosmic ]
T1447 A1447 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
K1477 N1477 Biomuta DOID:363 / uterine cancer [ icgc ]
S1479 Y1479 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1571 L1571 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
S1574 C1574 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1581 F1581 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1581 Y1581 Biomuta DOID:3571 / liver cancer [ cosmic ]
S1585 L1585 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S1585 * Biomuta DOID:1612 / breast cancer [ cosmic ]
S1591 N1591 Biomuta DOID:4159 / skin cancer [ cosmic ]
T1695 A1695 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T1695 I1695 Biomuta DOID:3565 / meningioma [ cosmic ]