iPTMnet Report for Q6PL24 (TMED8)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q6PL24 / TMED8_HUMAN
Protein Name Protein TMED8
Gene Name Name: TMED8
Synonyms:FAM15B;ORFNames:L10;
Organism Homo sapiens (Human)

PRO ID PR:Q6PL24
DAG View
PRO Name protein TMED8 (human)
Definition A protein TMED8 that is encoded in the genome of human.
Short Label hTMED8
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q6PL24 (TMED8) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S12 Phosphorylation PhosphoSitePlus
S21 Phosphorylation PhosphoSitePlus
S34 Phosphorylation PhosphoSitePlus
S39 Phosphorylation PhosphoSitePlus
S50 Phosphorylation PhosphoSitePlus
S63 Phosphorylation PhosphoSitePlus
S71 Phosphorylation PhosphoSitePlus
K75 Acetylation PhosphoSitePlus
T85 Phosphorylation PhosphoSitePlus
K95 Ubiquitination PhosphoSitePlus
K112 Ubiquitination PhosphoSitePlus
Y113 Phosphorylation PhosphoSitePlus
K151 Ubiquitination PhosphoSitePlus
S153 Phosphorylation PhosphoSitePlus
K169 Acetylation PhosphoSitePlus   UniProt 19608861
K172 Acetylation PhosphoSitePlus
S181 Phosphorylation PhosphoSitePlus
T192 Phosphorylation PhosphoSitePlus
T197 Phosphorylation PhosphoSitePlus
S265 Phosphorylation PhosphoSitePlus
S267 Phosphorylation PhosphoSitePlus
S268 Phosphorylation PhosphoSitePlus
S284 Phosphorylation PhosphoSitePlus
K304 Ubiquitination PhosphoSitePlus
Y309 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S12 P12 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ]
S50 C50 Biomuta DOID:1324 / lung cancer [ cosmic ]
S63 L63 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:4362 / cervical cancer [ cosmic, icgc ]
K75 R75 Biomuta DOID:4159 / skin cancer [ cosmic ]
K169 E169 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K169 T169 Biomuta DOID:4159 / skin cancer [ cosmic ]
K172 R172 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
K172 E172 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]