iPTMnet Report for Q6PJI9 (WDR59)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q6PJI9 / WDR59_HUMAN
Protein Name GATOR2 complex protein WDR59
Gene Name Name: WDR59
Synonyms:KIAA1923;ORFNames:FP977;
Organism Homo sapiens (Human)

PRO ID PR:Q6PJI9
DAG View
PRO Name GATOR complex protein WDR59 (human)
Definition A GATOR complex protein WDR59 that is encoded in the genome of human.
Short Label hWDR59
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q6PJI9 (WDR59) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K91 Ubiquitination PhosphoSitePlus
K140 Ubiquitination PhosphoSitePlus
T142 Phosphorylation PhosphoSitePlus
S146 Phosphorylation PhosphoSitePlus
K155 Ubiquitination PhosphoSitePlus
K159 Ubiquitination PhosphoSitePlus
S181 Phosphorylation PhosphoSitePlus
K217 Ubiquitination PhosphoSitePlus
K226 Ubiquitination PhosphoSitePlus
C233 Methylation IEDB 31844290
K239 Ubiquitination PhosphoSitePlus
K298 Ubiquitination PhosphoSitePlus
K381 Ubiquitination PhosphoSitePlus
K466 Ubiquitination PhosphoSitePlus
K472 Ubiquitination PhosphoSitePlus
S564 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
T566 Phosphorylation PhosphoSitePlus
S577 Phosphorylation PhosphoSitePlus
K588 Ubiquitination PhosphoSitePlus
S603 Phosphorylation PhosphoSitePlus
T605 Phosphorylation PhosphoSitePlus
S607 Phosphorylation PhosphoSitePlus
K609 Ubiquitination PhosphoSitePlus
S624 Phosphorylation PhosphoSitePlus
S629 Phosphorylation PhosphoSitePlus
K642 Ubiquitination PhosphoSitePlus
K646 Ubiquitination PhosphoSitePlus
K679 Ubiquitination PhosphoSitePlus
S772 Phosphorylation PhosphoSitePlus
S773 Phosphorylation PhosphoSitePlus
S778 Phosphorylation PhosphoSitePlus
S780 Phosphorylation PhosphoSitePlus
Y782 Phosphorylation PhosphoSitePlus
S784 Phosphorylation PhosphoSitePlus
T786 Phosphorylation PhosphoSitePlus
S787 Phosphorylation PhosphoSitePlus
S788 Phosphorylation PhosphoSitePlus
S790 Phosphorylation PhosphoSitePlus
S792 Phosphorylation PhosphoSitePlus
S793 Phosphorylation PhosphoSitePlus
S795 Phosphorylation PhosphoSitePlus
S821 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S822 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S830 Phosphorylation PhosphoSitePlus   UniProt 23186163
T832 Phosphorylation PhosphoSitePlus
Y833 Phosphorylation PhosphoSitePlus
S834 Phosphorylation PhosphoSitePlus
K863 Acetylation PhosphoSitePlus
K863 Ubiquitination PhosphoSitePlus
K864 Ubiquitination PhosphoSitePlus
K884 Ubiquitination PhosphoSitePlus
S887 Phosphorylation PhosphoSitePlus
K894 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S564 Phosphorylation HPRD 19413330, 19664994
Y600 Phosphorylation HPRD 20068231
S601 Phosphorylation HPRD 20068231
S603 Phosphorylation HPRD 20068231
S607 Phosphorylation HPRD 20068231
S821 Phosphorylation HPRD 18669648, 20068231
S822 Phosphorylation HPRD 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S564 P564 Biomuta DOID:5158 / pleural cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
S601 N601 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K609 R609 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S624 L624 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T786 I786 Biomuta DOID:3571 / liver cancer [ cosmic ]
S788 F788 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S792 F792 Biomuta DOID:4159 / skin cancer [ cosmic ]
S822 L822 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S830 I830 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S887 F887 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]