iPTMnet Report for Q6PJF5 (RHBDF2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q6PJF5 / RHDF2_HUMAN
Protein Name Inactive rhomboid protein 2
Gene Name Name: RHBDF2
Synonyms:IRHOM2,RHBDL5,RHBDL6;
Organism Homo sapiens (Human)

PRO ID PR:Q6PJF5
DAG View
PRO Name inactive rhomboid protein 2 (human)
Definition An inactive rhomboid protein 2 that is encoded in the genome of human.
Short Label hRHBDF2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q6PJF5 (RHBDF2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K81 Ubiquitination PhosphoSitePlus
K87 Ubiquitination PhosphoSitePlus
S90 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163
K104 Ubiquitination PhosphoSitePlus
S113 Phosphorylation PhosphoSitePlus   UniProt 23186163
S115 Phosphorylation PhosphoSitePlus
S117 Phosphorylation PhosphoSitePlus
K120 Methylation PhosphoSitePlus
S129 Phosphorylation PhosphoSitePlus
S143 Phosphorylation PhosphoSitePlus
S148 Phosphorylation PhosphoSitePlus
S166 Phosphorylation PhosphoSitePlus
S171 Phosphorylation PhosphoSitePlus
T175 Phosphorylation PhosphoSitePlus
S177 Phosphorylation PhosphoSitePlus
K179 Ubiquitination PhosphoSitePlus
R192 Methylation PhosphoSitePlus
T213 Phosphorylation PhosphoSitePlus
S227 Phosphorylation PhosphoSitePlus
Y229 Phosphorylation PhosphoSitePlus
S239 Phosphorylation PhosphoSitePlus
S244 Phosphorylation PhosphoSitePlus
S256 Phosphorylation PhosphoSitePlus
T288 Phosphorylation PhosphoSitePlus
S309 Phosphorylation PhosphoSitePlus
S313 Phosphorylation PhosphoSitePlus
S323 Phosphorylation PhosphoSitePlus
S325 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163
S328 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163
K337 Ubiquitination PhosphoSitePlus
S355 Phosphorylation IEDB 35494241
K358 Ubiquitination PhosphoSitePlus
S381 Phosphorylation PhosphoSitePlus
S385 Phosphorylation PhosphoSitePlus
S387 Phosphorylation PhosphoSitePlus
S388 Phosphorylation PhosphoSitePlus
T389 Phosphorylation PhosphoSitePlus
T422 Phosphorylation IEDB 35494241
T530 Phosphorylation PhosphoSitePlus
N584 N-Glycosylation GlyGen 24190977
S607 Phosphorylation PhosphoSitePlus
C608 Methylation IEDB 31844290
C670 Methylation IEDB 31844290
S700 Phosphorylation PhosphoSitePlus
T703 Phosphorylation PhosphoSitePlus
S708 Phosphorylation PhosphoSitePlus
C846 Methylation IEDB 31844290
Site PTM Type PTM Enzyme Score Source PMID
S61 Phosphorylation HPRD 18669648
S294 Phosphorylation HPRD 19651622, 20068231
S296 Phosphorylation HPRD 19651622, 18669648, 20068231
S299 Phosphorylation HPRD 19651622, 18669648, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S117 N117 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S143 N143 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S177 F177 Biomuta DOID:4159 / skin cancer [ cosmic ]
R192 Q192 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:8618 / oral cavity cancer [ cosmic ]
R192 W192 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
T288 M288 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S309 T309 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S355 F355 Biomuta DOID:4159 / skin cancer [ cosmic ]
S381 I381 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S385 I385 Biomuta DOID:363 / uterine cancer [ icgc ]
C608 Y608 Biomuta DOID:10534 / stomach cancer [ cosmic ]