iPTMnet Report for Q6PJ21 (SPSB3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q6PJ21 / SPSB3_HUMAN
Protein Name SPRY domain-containing SOCS box protein 3
Gene Name Name: SPSB3
Synonyms:C16orf31,SSB3;
Organism Homo sapiens (Human)

PRO ID PR:Q6PJ21
DAG View
PRO Name SPRY domain-containing SOCS box protein 3 (human)
Definition A SPRY domain-containing SOCS box protein 3 that is encoded in the genome of human.
Short Label hSPSB3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q6PJ21 (SPSB3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S119 Phosphorylation PhosphoSitePlus
S126 Phosphorylation PhosphoSitePlus
Y131 Phosphorylation PhosphoSitePlus
S132 Phosphorylation PhosphoSitePlus
K142 Ubiquitination PhosphoSitePlus
T170 Phosphorylation PhosphoSitePlus
K246 Ubiquitination PhosphoSitePlus
Y253 Phosphorylation PhosphoSitePlus
S258 Phosphorylation PhosphoSitePlus
T275 Phosphorylation PhosphoSitePlus
S276 Phosphorylation PhosphoSitePlus
Y279 Phosphorylation PhosphoSitePlus
S318 Phosphorylation PhosphoSitePlus
S320 Phosphorylation PhosphoSitePlus
S322 Phosphorylation PhosphoSitePlus
K325 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y131 H131 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K246 M246 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S318 I318 Biomuta DOID:363 / uterine cancer [ icgc ]