iPTMnet Report for Q6PIY7 (TENT2)
Protein Information
| UniProt AC / UniProt ID | Q6PIY7 / GLD2_HUMAN |
| Protein Name | Poly(A) RNA polymerase GLD2 |
| Gene Name | Name: TENT2 Synonyms:GLD2; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q6PIY7 |
| PRO Name | poly(A) RNA polymerase GLD2 (human) |
| Definition | A poly(A) RNA polymerase GLD2 that is encoded in the genome of human. |
| Short Label | hTENT2 |
| Category | organism-gene |
Q6PIY7 (TENT2) as Substrate
| Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
|---|---|---|---|---|---|---|
| Y58 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S62 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 20068231 | ||
| S69 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 19690332 | ||
| R73 | Methylation | score1 | PhosphoSitePlus | |||
| R75 | Methylation | score1 | PhosphoSitePlus | |||
| K82 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K89 | Ubiquitination | score1 | PhosphoSitePlus | |||
| R90 | Methylation | score1 | PhosphoSitePlus | |||
| R92 | Methylation | score1 | PhosphoSitePlus | |||
| S95 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
| S110 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S116 | Phosphorylation | P31749 (AKT1) , P17612 (PRKACA) , P22694 (PRKACB) , P22612 (PRKACG) | score3 | PhosphoSitePlus Signor | 31057087 | |
| R131 | Methylation | score1 | PhosphoSitePlus | |||
| C132 | Methylation | score1 | IEDB | 31844290 | ||
| K153 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K155 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K175 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S251 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y253 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K268 | Ubiquitination | score1 | PhosphoSitePlus | |||
| R325 | Methylation | score1 | PhosphoSitePlus | |||
| K428 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y429 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T439 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T441 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K455 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S461 | Phosphorylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S69 | F69 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| R73 | * | Biomuta | DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] | |
| R73 | L73 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
| R90 | W90 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ] | |
| R90 | Q90 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
| R92 | H92 | Biomuta | DOID:1612 / breast cancer [ cosmic, icgc ] | |
| R92 | C92 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ] | |
| K175 | N175 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
| K175 | T175 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| R325 | S325 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
| R325 | H325 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| R325 | L325 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
| T439 | P439 | Biomuta | DOID:263 / kidney cancer [ cosmic ] | |
| K455 | * | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] |
DAG View