iPTMnet Report for Q6PFW1 (PPIP5K1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q6PFW1 / VIP1_HUMAN
Protein Name Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1
Gene Name Name: PPIP5K1
Synonyms:HISPPD2A,IP6K,IPS1,KIAA0377,VIP1;
Organism Homo sapiens (Human)

PRO ID PR:Q6PFW1
DAG View
PRO Name inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 (human)
Definition An inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 that is encoded in the genome of human.
Short Label hPPIP5K1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q6PFW1 (PPIP5K1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K126 Ubiquitination PhosphoSitePlus
K241 Ubiquitination PhosphoSitePlus
Y267 Phosphorylation PhosphoSitePlus
K274 Ubiquitination PhosphoSitePlus
K281 Ubiquitination PhosphoSitePlus
Y293 Phosphorylation PhosphoSitePlus
K344 Ubiquitination PhosphoSitePlus
K351 Ubiquitination PhosphoSitePlus
K457 Ubiquitination PhosphoSitePlus
S475 Phosphorylation PhosphoSitePlus
K500 Ubiquitination PhosphoSitePlus
Y553 Phosphorylation PhosphoSitePlus
K573 Ubiquitination PhosphoSitePlus
T585 Phosphorylation PhosphoSitePlus
T601 Phosphorylation PhosphoSitePlus
Y730 Phosphorylation PhosphoSitePlus
Y739 Phosphorylation PhosphoSitePlus
S764 Phosphorylation PhosphoSitePlus
K765 Ubiquitination PhosphoSitePlus
Y776 Phosphorylation PhosphoSitePlus
S779 Phosphorylation PhosphoSitePlus
S944 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
T963 Phosphorylation PhosphoSitePlus
S964 Phosphorylation PhosphoSitePlus
S977 Phosphorylation PhosphoSitePlus
S987 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1006 Phosphorylation PhosphoSitePlus
S1037 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1073 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1075 Phosphorylation PhosphoSitePlus
T1149 Phosphorylation PhosphoSitePlus
S1152 Phosphorylation PhosphoSitePlus   UniProt 23186163, 18220336
C1310 Methylation IEDB 31844290
Site PTM Type PTM Enzyme Score Source PMID
K813 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S475 Phosphorylation HPRD 20068231
Y730 Phosphorylation HPRD 19413330
S940 Phosphorylation HPRD 19413330
T1124 Phosphorylation HPRD 19651622, 18767875, 18669648
S1127 Phosphorylation HPRD 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y267 D267 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K274 R274 Biomuta DOID:1324 / lung cancer [ cosmic ]
K281 N281 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S1127 L1127 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1152 L1152 Biomuta DOID:4159 / skin cancer [ cosmic ]