iPTMnet Report for Q6P996 (PDXDC1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q6P996 / PDXD1_HUMAN
Protein Name Pyridoxal-dependent decarboxylase domain-containing protein 1
Gene Name Name: PDXDC1
Synonyms:KIAA0251;
Organism Homo sapiens (Human)

PRO ID PR:Q6P996
DAG View
PRO Name pyridoxal-dependent decarboxylase domain-containing protein 1 (human)
Definition A pyridoxal-dependent decarboxylase domain-containing protein 1 that is encoded in the genome of human.
Short Label hPDXDC1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q6P996 (PDXDC1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S4 Phosphorylation PhosphoSitePlus
T12 Phosphorylation PhosphoSitePlus
K18 Ubiquitination PhosphoSitePlus
K21 Ubiquitination PhosphoSitePlus
K25 Ubiquitination PhosphoSitePlus
S30 Phosphorylation PhosphoSitePlus
S79 Phosphorylation PhosphoSitePlus
S97 Phosphorylation PhosphoSitePlus
K107 Ubiquitination PhosphoSitePlus
K148 Ubiquitination PhosphoSitePlus
S212 Phosphorylation PhosphoSitePlus
K226 Ubiquitination PhosphoSitePlus
K252 Ubiquitination PhosphoSitePlus
K331 Ubiquitination PhosphoSitePlus
K335 Ubiquitination PhosphoSitePlus
K358 Ubiquitination PhosphoSitePlus
K372 Ubiquitination PhosphoSitePlus
S387 Phosphorylation PhosphoSitePlus
S401 Phosphorylation PhosphoSitePlus
K406 Ubiquitination PhosphoSitePlus
T414 Phosphorylation PhosphoSitePlus   UniProt 23186163
S416 Phosphorylation PhosphoSitePlus
S424 Phosphorylation PhosphoSitePlus
C425 Methylation IEDB 31844290
T470 Phosphorylation PhosphoSitePlus
K500 Ubiquitination PhosphoSitePlus
T506 O-Glycosylation GlyGen 29351928
S518 O-Glycosylation GlyGen 29351928
K536 Ubiquitination PhosphoSitePlus
K550 Ubiquitination PhosphoSitePlus
K551 Ubiquitination PhosphoSitePlus
K562 Ubiquitination PhosphoSitePlus
Y567 Phosphorylation PhosphoSitePlus
K568 Ubiquitination PhosphoSitePlus
S572 Phosphorylation PhosphoSitePlus
K615 Ubiquitination PhosphoSitePlus
K626 Ubiquitination PhosphoSitePlus
S646 Phosphorylation PhosphoSitePlus
S652 Phosphorylation PhosphoSitePlus   UniProt 20068231
K659 Ubiquitination PhosphoSitePlus
T662 Phosphorylation PhosphoSitePlus
S669 Phosphorylation PhosphoSitePlus
S672 Phosphorylation PhosphoSitePlus
Y677 Phosphorylation PhosphoSitePlus
Y679 Phosphorylation PhosphoSitePlus
K680 Methylation PhosphoSitePlus
K680 Ubiquitination PhosphoSitePlus
T687 Phosphorylation PhosphoSitePlus
T691 Phosphorylation P28482 (MAPK1) neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 22028470, 16964243
S695 Phosphorylation PhosphoSitePlus
T697 Phosphorylation PhosphoSitePlus
K705 Ubiquitination PhosphoSitePlus
K708 Ubiquitination PhosphoSitePlus
S710 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163
S714 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S718 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
T720 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S721 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S722 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S724 Phosphorylation PhosphoSitePlus
K731 Ubiquitination PhosphoSitePlus
S736 Phosphorylation PhosphoSitePlus
S737 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
T743 Phosphorylation PhosphoSitePlus
S757 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
T761 Phosphorylation PhosphoSitePlus
S779 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332, 23186163, 17081983
S786 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
R788 Methylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S79 Phosphorylation HPRD 20068231
S652 Phosphorylation HPRD 20068231
T691 Phosphorylation HPRD 16964243
S714 Phosphorylation HPRD 18669648, 17081983
S718 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231
T720 Phosphorylation HPRD 18669648, 17081983
S721 Phosphorylation HPRD 18669648, 17081983
S722 Phosphorylation HPRD 18669648, 17081983
S724 Phosphorylation HPRD 17081983
S736 Phosphorylation HPRD 19651622, 17081983
S737 Phosphorylation HPRD 17081983, 20068231
S757 Phosphorylation HPRD 18669648, 20068231
T761 Phosphorylation HPRD 20068231
S779 Phosphorylation HPRD 17525332, 20068231
S786 Phosphorylation HPRD 17287340
Site PTM Type PTM Enzyme Score Source PMID
K26 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
K40 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
K41 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K372 R372 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S401 * Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S401 L401 Biomuta DOID:4159 / skin cancer [ cosmic ]
S416 P416 Biomuta DOID:4159 / skin cancer [ cosmic ]
S518 C518 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K550 N550 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K551 * Biomuta DOID:3571 / liver cancer [ cosmic ]
K551 T551 Biomuta DOID:363 / uterine cancer [ icgc ]
Y567 H567 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T662 A662 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
T687 R687 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T691 M691 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K705 T705 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K708 * Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S718 G718 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S757 R757 Biomuta DOID:4159 / skin cancer [ cosmic ]
S779 * Biomuta DOID:263 / kidney cancer [ cosmic ]
R788 S788 Biomuta DOID:363 / uterine cancer [ icgc ]