iPTMnet Report for Q6P6C2 (ALKBH5)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q6P6C2 / ALKB5_HUMAN
Protein Name RNA demethylase ALKBH5
Gene Name Name: ALKBH5
Synonyms:ABH5,OFOXD1;
Organism Homo sapiens (Human)

PRO ID PR:Q6P6C2
DAG View
PRO Name RNA demethylase ALKBH5 (human)
Definition An alkylated DNA repair protein alkB 5 that is encoded in the genome of human.
Short Label hALKBH5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q6P6C2 (ALKBH5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 22814378
S5 Phosphorylation PhosphoSitePlus
K15 Ubiquitination PhosphoSitePlus
Y51 Phosphorylation PhosphoSitePlus
S54 Phosphorylation PhosphoSitePlus
K57 Acetylation PhosphoSitePlus
K57 Ubiquitination PhosphoSitePlus
Y60 Phosphorylation PhosphoSitePlus
S64 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332, ...24275569
S69 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
Y71 Phosphorylation PhosphoSitePlus   UniProt 19690332
K86 Acetylation PhosphoSitePlus
S96 Phosphorylation PhosphoSitePlus
K102 Sumoylation PhosphoSitePlus
K102 Ubiquitination PhosphoSitePlus
S112 Phosphorylation PhosphoSitePlus
K116 Ubiquitination PhosphoSitePlus
K132 Acetylation PhosphoSitePlus   UniProt 19608861
K132 Ubiquitination PhosphoSitePlus
K147 Ubiquitination PhosphoSitePlus
C227 Methylation IEDB 31844290
K235 Acetylation PhosphoSitePlus
K235 Ubiquitination PhosphoSitePlus
R250 Methylation PhosphoSitePlus
S252 Phosphorylation PhosphoSitePlus
C267 Methylation IEDB 31844290
T294 Phosphorylation PhosphoSitePlus
K295 Ubiquitination PhosphoSitePlus
S296 Phosphorylation PhosphoSitePlus
S312 Phosphorylation PhosphoSitePlus
K321 Acetylation PhosphoSitePlus
K321 Ubiquitination PhosphoSitePlus
K328 Sumoylation PhosphoSitePlus
S350 Phosphorylation PhosphoSitePlus
R359 Methylation PhosphoSitePlus   UniProt 24129315
S361 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 24489119, 23186163, 18669648, ...18220336
S363 Phosphorylation PhosphoSitePlus
S371 Phosphorylation PhosphoSitePlus   RLIMS-P 24489119
Y372 Phosphorylation PhosphoSitePlus
S374 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 24489119, 19690332
S375 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S379 Phosphorylation PhosphoSitePlus
S384 Phosphorylation PhosphoSitePlus   RLIMS-P 24489119
Site PTM Type PTM Enzyme Score Source PMID
S54 Phosphorylation HPRD 20068231
S64 Phosphorylation HPRD   phospho.ELM 19413330, 19664994, 18452278, ...19651622, 18669648, 20068231
S69 Phosphorylation HPRD   phospho.ELM 19413330, 19651622, 18669648, ...19664994, 18452278
Y71 Phosphorylation HPRD 19413330
S350 Phosphorylation HPRD 18212344
S361 Phosphorylation HPRD   phospho.ELM 18669648, 18220336, 20068231, ...17924679
S363 Phosphorylation HPRD 17081983
S371 Phosphorylation PhosphoSitePlus
S374 Phosphorylation PhosphoSitePlus
S375 Phosphorylation HPRD   phospho.ELM 18669648
S379 Phosphorylation HPRD 20068231
S384 Phosphorylation HPRD   PhosphoSitePlus 19664995, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y71 F71 Biomuta DOID:1324 / lung cancer [ cosmic ]
S112 P112 Biomuta DOID:1319 / brain cancer [ icgc ]
K116 N116 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
R359 W359 Biomuta DOID:1324 / lung cancer [ cosmic ]
S363 G363 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S379 C379 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S384 N384 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]