iPTMnet Report for Q6P5Z2 (PKN3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q6P5Z2 / PKN3_HUMAN
Protein Name Serine/threonine-protein kinase N3
Gene Name Name: PKN3
Synonyms:PKNBETA;
Organism Homo sapiens (Human)

PRO ID PR:Q6P5Z2
DAG View
PRO Name serine/threonine-protein kinase N3 (human)
Definition A serine/threonine-protein kinase N3 that is encoded in the genome of human.
Short Label hPKN3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q6P5Z2 (PKN3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K20 Ubiquitination PhosphoSitePlus
K29 Ubiquitination PhosphoSitePlus
T45 Phosphorylation PhosphoSitePlus
R58 Methylation PhosphoSitePlus
T135 Phosphorylation PhosphoSitePlus
K140 Ubiquitination PhosphoSitePlus
K155 Ubiquitination PhosphoSitePlus
S171 Phosphorylation PhosphoSitePlus   UniProt 23186163
K198 Ubiquitination PhosphoSitePlus
K202 Ubiquitination PhosphoSitePlus
S205 O-Glycosylation GlyGen 30379171
K213 Ubiquitination PhosphoSitePlus
K273 Ubiquitination PhosphoSitePlus
S299 Phosphorylation PhosphoSitePlus
S307 Phosphorylation HPRD   PhosphoSitePlus 18691976
S309 Phosphorylation HPRD   phospho.ELM 18669648
S466 Phosphorylation PhosphoSitePlus
S472 Phosphorylation PhosphoSitePlus
T480 Phosphorylation PhosphoSitePlus
S488 Phosphorylation PhosphoSitePlus
T492 Phosphorylation PhosphoSitePlus
S494 Phosphorylation PhosphoSitePlus
K499 Ubiquitination PhosphoSitePlus
T508 Phosphorylation HPRD   PhosphoSitePlus 18691976
K512 Ubiquitination PhosphoSitePlus
T523 Phosphorylation HPRD   PhosphoSitePlus 18691976
S524 Phosphorylation PhosphoSitePlus
T527 Phosphorylation PhosphoSitePlus
S544 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 23186163, 19369195, ...17192257, 19651622, 18669648
S544 Phosphorylation Q6P5Z2 (PKN3) HPRD 19651622, 18691976, 18669648, ...17192257
S548 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19651622, 18669648, 18691976
T550 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17192257
T550 Phosphorylation Q6P5Z2 (PKN3) HPRD 17192257
K583 Acetylation PhosphoSitePlus
K583 Ubiquitination PhosphoSitePlus
K588 Ubiquitination PhosphoSitePlus
K592 Ubiquitination PhosphoSitePlus
K686 Ubiquitination PhosphoSitePlus
T716 Phosphorylation HPRD   PhosphoSitePlus 18691976
S717 Phosphorylation PhosphoSitePlus
T718 Phosphorylation HPRD   phospho.ELM   PRO   PhosphoSitePlus   UniProt 18669648, 15282551
T722 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 18669648
K796 Ubiquitination PhosphoSitePlus
K813 Ubiquitination PhosphoSitePlus
T820 Phosphorylation PhosphoSitePlus
T860 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 18669648, 19369195


Q6P5Z2 (PKN3) as PTM Enzyme



Substrate Site Score Source PMID
P00533 (EGFR) T678 PhosphoSitePlus 21749319
P30622 (CLIP1) S312 neXtProt   PhosphoSitePlus 21749319
Q6P5Z2 (PKN3) S544 HPRD 19651622, 18691976, 18669648, ...17192257
Q6P5Z2 (PKN3) T550 HPRD 17192257


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048787 (hPKN3/Phos:1) pT718 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q8N392 (ARHGAP18) T154 Q6P5Z2 (PKN3) unknown eFIP 33092266


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S299 F299 Biomuta DOID:4159 / skin cancer [ cosmic ]
S307 I307 Biomuta DOID:1324 / lung cancer [ cosmic ]
S472 T472 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K512 Q512 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S548 Y548 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K686 R686 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T860 I860 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]