iPTMnet Report for Q6P597 (KLC3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q6P597 / KLC3_HUMAN
Protein Name Kinesin light chain 3
Gene Name Name: KLC3
Synonyms:KLC2,KLC2L;
Organism Homo sapiens (Human)

PRO ID PR:Q6P597
DAG View
PRO Name kinesin light chain 3 (human)
Definition A kinesin light chain 3 that is encoded in the genome of human.
Short Label hKLC3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q6P597 (KLC3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S10 Phosphorylation PhosphoSitePlus
S162 Phosphorylation PhosphoSitePlus
S167 Phosphorylation PhosphoSitePlus
S173 Phosphorylation PhosphoSitePlus
Y201 Phosphorylation PhosphoSitePlus
S361 Phosphorylation PhosphoSitePlus
T377 Phosphorylation PhosphoSitePlus
S383 Phosphorylation PhosphoSitePlus
Y385 Phosphorylation PhosphoSitePlus
K399 Ubiquitination PhosphoSitePlus
S429 Phosphorylation PhosphoSitePlus
S430 Phosphorylation PhosphoSitePlus
S431 Phosphorylation PhosphoSitePlus
S443 Phosphorylation PhosphoSitePlus
K462 Methylation PhosphoSitePlus
S466 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692, ...19690332
T469 Phosphorylation PhosphoSitePlus
S495 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S497 Phosphorylation PhosphoSitePlus
T498 Phosphorylation PhosphoSitePlus   UniProt 21406692
S502 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692
Site PTM Type PTM Enzyme Score Source PMID
S466 Phosphorylation HPRD 19413330, 18669648, 19664995
S495 Phosphorylation HPRD 18669648
S502 Phosphorylation HPRD 18669648, 19415658


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S167 F167 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y201 N201 Biomuta DOID:4159 / skin cancer [ cosmic ]
S383 L383 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ]
S383 * Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
K399 E399 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K462 N462 Biomuta DOID:1612 / breast cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T469 I469 Biomuta DOID:2531 / hematologic cancer [ cosmic ]