iPTMnet Report for Q6P3W7 (SCYL2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q6P3W7 / SCYL2_HUMAN
Protein Name SCY1-like protein 2
Gene Name Name: SCYL2
Synonyms:CVAK104;
Organism Homo sapiens (Human)

PRO ID PR:Q6P3W7
DAG View
PRO Name SCY1-like protein 2 (human)
Definition A SCY1-like protein 2 that is encoded in the genome of human.
Short Label hSCYL2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q6P3W7 (SCYL2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K9 Acetylation PhosphoSitePlus
K79 Ubiquitination PhosphoSitePlus
K148 Ubiquitination PhosphoSitePlus
Y275 Phosphorylation PhosphoSitePlus
S277 Phosphorylation PhosphoSitePlus
S350 Phosphorylation PhosphoSitePlus
C375 Methylation IEDB 31844290
T438 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
T440 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S622 Phosphorylation PhosphoSitePlus
S677 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
K683 Ubiquitination PhosphoSitePlus
K688 Methylation PhosphoSitePlus
K703 Ubiquitination PhosphoSitePlus
T708 Phosphorylation PhosphoSitePlus   UniProt 23186163
T712 Phosphorylation PhosphoSitePlus
K714 Ubiquitination PhosphoSitePlus
S732 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...34019948, 34725712, 30059200, 30620550, 35132862, 29485866, 32119511, 29351928, 28657654
S734 O-Glycosylation GlyGen 23301498, 33214551, 32938750, ...35138101, 34019948, 34725712, 30059200, 30620550, 35132862, 29485866, 32119511, 29351928, 28657654
S736 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...34019948, 34725712, 30059200, 30620550, 35132862, 29485866, 32119511, 29351928, 28657654
T737 Phosphorylation PhosphoSitePlus
S740 O-Glycosylation GlyGen 23301498, 33214551, 32938750, ...35138101, 34019948, 34725712, 30059200, 30620550, 35132862, 29485866, 32119511, 29351928, 28657654
S741 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...34019948, 34725712, 30059200, 30620550, 35132862, 29485866, 32119511, 29351928, 28657654
T745 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...34019948, 34725712, 30059200, 30620550, 35132862, 29485866, 32119511, 29351928, 28657654
S751 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...34019948, 34725712, 30059200, 30620550, 35132862, 29485866, 32119511, 29351928, 28657654
S751 Phosphorylation PhosphoSitePlus
S759 Phosphorylation PhosphoSitePlus
T760 Phosphorylation PhosphoSitePlus
Y795 Phosphorylation PhosphoSitePlus
T810 Phosphorylation PhosphoSitePlus
K848 Ubiquitination PhosphoSitePlus
S857 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y275 H275 Biomuta DOID:363 / uterine cancer [ icgc ]
T440 N440 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:2021 / placenta cancer [ cosmic ]
K714 E714 Biomuta DOID:3571 / liver cancer [ cosmic ]
T737 I737 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S740 F740 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S741 Y741 Biomuta DOID:1324 / lung cancer [ cosmic ]
T745 S745 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
T745 A745 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ]
T745 I745 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S857 P857 Biomuta DOID:2531 / hematologic cancer [ cosmic, icgc ]