iPTMnet Report for Q6P3S1 (DENND1B)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q6P3S1 / DEN1B_HUMAN
Protein Name DENN domain-containing protein 1B
Gene Name Name: DENND1B
Synonyms:C1orf218;
Organism Homo sapiens (Human)

PRO ID PR:Q6P3S1
DAG View
PRO Name DENN domain-containing protein 1B (human)
Definition A DENN domain-containing protein 1B that is encoded in the genome of human.
Short Label hDENND1B
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q6P3S1 (DENND1B) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y134 Phosphorylation PhosphoSitePlus
K362 Methylation PhosphoSitePlus
K369 Methylation PhosphoSitePlus
K391 Ubiquitination PhosphoSitePlus
K456 Ubiquitination PhosphoSitePlus
Y475 Phosphorylation PhosphoSitePlus
S480 Phosphorylation PhosphoSitePlus
S481 Phosphorylation PhosphoSitePlus
Y484 Phosphorylation PhosphoSitePlus
T485 Phosphorylation PhosphoSitePlus
Y488 Phosphorylation PhosphoSitePlus
S514 Phosphorylation PhosphoSitePlus
Y520 Phosphorylation PhosphoSitePlus
S549 Phosphorylation PhosphoSitePlus
S552 Phosphorylation PhosphoSitePlus
T559 Phosphorylation PhosphoSitePlus
S576 Phosphorylation PhosphoSitePlus
S579 Phosphorylation PhosphoSitePlus
S590 Phosphorylation PhosphoSitePlus
S596 Phosphorylation PhosphoSitePlus
T605 Phosphorylation PhosphoSitePlus
S608 Phosphorylation PhosphoSitePlus
S612 Phosphorylation PhosphoSitePlus
S646 Phosphorylation PhosphoSitePlus
S652 Phosphorylation PhosphoSitePlus   UniProt 19690332
S653 Phosphorylation PhosphoSitePlus
S690 Phosphorylation PhosphoSitePlus
S711 Phosphorylation PhosphoSitePlus
S723 Phosphorylation PhosphoSitePlus
S724 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
K391 Acetylation PhosphoSitePlus
S399 Phosphorylation PhosphoSitePlus
K415 Acetylation PhosphoSitePlus
K417 Acetylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S399 F399 Biomuta DOID:4159 / skin cancer [ cosmic ]
S481 T481 Biomuta DOID:4159 / skin cancer [ cosmic ]
T605 M605 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S652 F652 Biomuta DOID:4159 / skin cancer [ cosmic ]
S653 C653 Biomuta DOID:1612 / breast cancer [ cosmic ]
S711 L711 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
S723 L723 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S724 L724 Biomuta [ cosmic ] DOID:4159 / skin cancer [ cosmic ]